Yıl: 2020 Cilt: 9 Sayı: 1 Sayfa Aralığı: 53 - 59 Metin Dili: İngilizce İndeks Tarihi: 06-11-2020

Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease

Öz:
INTRODUCTION: Despite technical and medical advances,SVGD remains a significant problem that is associated withhigh morbidity and mortality rates. EAT communicates locallywith coronary vessels and myocardium through paracrine orvasocrine pathways. Although the relationship between EATand CAD is well known, there is not sufficient informationabout effect of EAT on SVGD. Therefore, we aimed toinvestigate the relationship between EAT and SVGD.METHODS: The study population consisted of 124consecutive patients who underwent elective CAG more thanone year after CABG surgery. The patients were divided intotwo groups depending on the extent of SVG patency. EATthickness measurements were determined from the lowechogenic density area perpendicular to lines drawn from theparasternal long and short axes to the free wall of the rightventricle.RESULTS: EAT thickness was significantly higher in theSVGD (+) group than in the SVGD (-) group (p < 0.001). Themultivariate logistic regression models revealed that EATthickness (p < 0.001, Odds ratio (OR) = 3.65, 95% Confidenceinterval (C.I.) = 2.52–8.12) was found to be independent factorfor predicting SVG stenosis. An EAT thickness value of > 7.4mm has 86.4 % sensitivity, 69.1 % specificity for the predictionof SVG stenosis.DISCUSSION AND CONCLUSION: EAT thickness is relatedto the presence of SVG stenosis. EAT thickness therefore couldserve as an easily measurable non-invasive adjunctive markerto classical risk factors for the prediction of SVG stenosis.
Anahtar Kelime:

Epikardiyal Yağ Dokusu Kalınlığı ve Safen Ven Greft Hastalığının Patofizyolojisi ile İlişkisi

Öz:
GİRİŞ ve AMAÇ: Teknik ve tıbbi ilerlemelere rağmen SVGH, yüksek morbidite ve mortalite oranları ile önemli bir sorun olmaya devam etmektedir. EYD, parakrin veya vazokrin yolaklar ile lokal olarak koroner damarlar ve miyokard ile iletişim kurar. EYD ve KAH arasındaki ilişki iyi bilinmesine rağmen, EYD'nin SVGH üzerindeki etkisi hakkında yeterli bilgi yoktur. Bu nedenle EYD ve SVGH arasındaki ilişkiyi araştırmayı amaçladık. YÖNTEM ve GEREÇLER: Çalışma popülasyonu, KABG cerrahisinden bir yıldan fazla bir süre sonra elektif KAG uygulanan 124 ardışık hastadan oluşmaktaydı. Hastalar SVG açıklığının derecesine göre iki gruba ayrıldı. EYD kalınlığı ölçümleri, parasternal uzun ve kısa eksenlerden sağ ventrikülün serbest duvarına çizilen çizgilere dik olan düşük ekojenik yoğunluk alanından belirlendi. BULGULAR: EYD kalınlığı SVGH (+) grubunda SVGH (-) grubuna göre anlamlı olarak daha yüksekti (p <0.001). Çok değişkenli lojistik regresyon modelleri, EYD kalınlığının (p <0.001, Risk oranı (OR) = 3.65,% 95 Güven aralığı (C.I.) = 2.52–8.12) SVG darlığını öngörmede bağımsız bir faktör olduğunu ortaya koymuştur. 7,4 mm'den büyük bir EYD kalınlığı değeri, SVG darlığının öngörülmesi için% 86,4 duyarlılığa,% 69,1 özgüllüğe sahiptir. TARTIŞMA ve SONUÇ: EYD kalınlığı SVG darlığının varlığı ile ilişkilidir. Bu nedenle EYD kalınlığı, SVG darlığının öngörülmesi için klasik risk faktörlerine ilave olarak kolayca ölçülebilen girişimsel olmayan bir yardımcı belirteç görevi görebilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Doğuş M, YAVUZ F, KÜÇÜKOSMANOĞLU M, Yıldırım A, Kilic S (2020). Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. , 53 - 59.
Chicago Doğuş Mustafa,YAVUZ FETHİ,KÜÇÜKOSMANOĞLU Mehmet,Yıldırım Arafat,Kilic Salih Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. (2020): 53 - 59.
MLA Doğuş Mustafa,YAVUZ FETHİ,KÜÇÜKOSMANOĞLU Mehmet,Yıldırım Arafat,Kilic Salih Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. , 2020, ss.53 - 59.
AMA Doğuş M,YAVUZ F,KÜÇÜKOSMANOĞLU M,Yıldırım A,Kilic S Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. . 2020; 53 - 59.
Vancouver Doğuş M,YAVUZ F,KÜÇÜKOSMANOĞLU M,Yıldırım A,Kilic S Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. . 2020; 53 - 59.
IEEE Doğuş M,YAVUZ F,KÜÇÜKOSMANOĞLU M,Yıldırım A,Kilic S "Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease." , ss.53 - 59, 2020.
ISNAD Doğuş, Mustafa vd. "Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease". (2020), 53-59.
APA Doğuş M, YAVUZ F, KÜÇÜKOSMANOĞLU M, Yıldırım A, Kilic S (2020). Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. Kocaeli Tıp Dergisi, 9(1), 53 - 59.
Chicago Doğuş Mustafa,YAVUZ FETHİ,KÜÇÜKOSMANOĞLU Mehmet,Yıldırım Arafat,Kilic Salih Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. Kocaeli Tıp Dergisi 9, no.1 (2020): 53 - 59.
MLA Doğuş Mustafa,YAVUZ FETHİ,KÜÇÜKOSMANOĞLU Mehmet,Yıldırım Arafat,Kilic Salih Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. Kocaeli Tıp Dergisi, vol.9, no.1, 2020, ss.53 - 59.
AMA Doğuş M,YAVUZ F,KÜÇÜKOSMANOĞLU M,Yıldırım A,Kilic S Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. Kocaeli Tıp Dergisi. 2020; 9(1): 53 - 59.
Vancouver Doğuş M,YAVUZ F,KÜÇÜKOSMANOĞLU M,Yıldırım A,Kilic S Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease. Kocaeli Tıp Dergisi. 2020; 9(1): 53 - 59.
IEEE Doğuş M,YAVUZ F,KÜÇÜKOSMANOĞLU M,Yıldırım A,Kilic S "Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease." Kocaeli Tıp Dergisi, 9, ss.53 - 59, 2020.
ISNAD Doğuş, Mustafa vd. "Epicardial Adipose Tissue Thickness and Its Relationship With The Pathophysiology of Saphenous Vein Graft Disease". Kocaeli Tıp Dergisi 9/1 (2020), 53-59.