Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study

The study aim to determine the clinicopathological factors for disease-free survival (DFS) and overall survival (OS) in women with vulvarcancer and to analyze the the possible effect of metformin on survival of the patients. From 2011 to 2017, medical records of 142patients who underwent primary radical surgery for VC at 6 referral centers in Turkey were collected, retrospectively. The median ageof the cohort was 67.0 years. 124 patients underwent radical surgery and inguinofemoral lymphadenectomy. The overall recurrencerate was 33.8% within a median follow-up time of 22 months. Five-year DFS and OS rates were 55.8% and 62.6%, respectively.Multivariate analysis showed surgical margin (HR:6.4, p= 0.017 for DFS; HR:13.6, p=0.009 for OS) and lymph node metastasis (HR:4.1, p= 0.014 for DFS; HR: 6.3, p= 0.020 for OS) were the independent prognostic factors. There was no statistically difference inDFS and OS for patients who had used metformin.

Anahtar Kelime:

Vulva Skuamöz Hücreli Kanserinde Prognostik Faktörler: Retrospektif Çok Merkezli Bir Çalışma

Öz:

Bu çalışma vulva kanserinde klinikopatolojik faktörlerin ve metforminin hastalıksız sağkalım (DFS) ve genel sağkalım (OS) üzerine etkilerini olan ortaya koymayı amaçlamaktadır. Çalışmada ülkemizde 2011-2017 yılları arasında, 6 referans merkezde vulva kanseri nedeniyle primer radikal cerrahi uygulanan 142 hastanın tıbbi kayıtları retrospektif olarak incelendi. Median yaşı 67.0 olan hastalardan 124’üne radikal cerrahi ve inguinofemoral lenfadenektomi yapıldı. 22 aylık median takip süresince rekürrens oranı %33.8 olarak saptandı. Beş yıllık DFS ve OS oranları sırasıyla % 55.8 ve % 62.6 olarak gösterildi. Çok değişkenli analizlerde cerrahi sınır (HR: 6.4, p= 0.017; DFS için; HR: 13.6, p= 0.009 OS için) ve lenf nodu metastazı (HR: 4.1, p= 0.014 için DFS; HR: 6.3, p = 0.020 OS için) bağımsız prognostik faktörler olarak saptandı. Vulva kanserinde metformin kullanımın DFS ve OS’a istatistiksel olarak etkisi olmadığı görüldü.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kuru O, Akgor U, Çakır İ, tosun ö, Temel Yuksel I, Ulker V, Meydanli M, Sanci M, gokcu m, Topuz S, Yildiz F, sakinci m, salman m, ÖZGÜL N, Yuce K, Ayhan A (2020). Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. , 54 - 62. 10.4999/uhod.204053
Chicago	Kuru Oguzhan,Akgor Utku,Çakır İlker,tosun özgür aydın,Temel Yuksel Ilkbal,Ulker Volkan,Meydanli Mehmet Mutlu,Sanci Muzaffer,gokcu mehmet,Topuz Samet,Yildiz Ferah,sakinci mehmet,salman mehmet coskun,ÖZGÜL Nejat,Yuce Kunter,Ayhan Ali Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. (2020): 54 - 62. 10.4999/uhod.204053
MLA	Kuru Oguzhan,Akgor Utku,Çakır İlker,tosun özgür aydın,Temel Yuksel Ilkbal,Ulker Volkan,Meydanli Mehmet Mutlu,Sanci Muzaffer,gokcu mehmet,Topuz Samet,Yildiz Ferah,sakinci mehmet,salman mehmet coskun,ÖZGÜL Nejat,Yuce Kunter,Ayhan Ali Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. , 2020, ss.54 - 62. 10.4999/uhod.204053
AMA	Kuru O,Akgor U,Çakır İ,tosun ö,Temel Yuksel I,Ulker V,Meydanli M,Sanci M,gokcu m,Topuz S,Yildiz F,sakinci m,salman m,ÖZGÜL N,Yuce K,Ayhan A Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. . 2020; 54 - 62. 10.4999/uhod.204053
Vancouver	Kuru O,Akgor U,Çakır İ,tosun ö,Temel Yuksel I,Ulker V,Meydanli M,Sanci M,gokcu m,Topuz S,Yildiz F,sakinci m,salman m,ÖZGÜL N,Yuce K,Ayhan A Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. . 2020; 54 - 62. 10.4999/uhod.204053
IEEE	Kuru O,Akgor U,Çakır İ,tosun ö,Temel Yuksel I,Ulker V,Meydanli M,Sanci M,gokcu m,Topuz S,Yildiz F,sakinci m,salman m,ÖZGÜL N,Yuce K,Ayhan A "Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study." , ss.54 - 62, 2020. 10.4999/uhod.204053
ISNAD	Kuru, Oguzhan vd. "Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study". (2020), 54-62. https://doi.org/10.4999/uhod.204053

APA	Kuru O, Akgor U, Çakır İ, tosun ö, Temel Yuksel I, Ulker V, Meydanli M, Sanci M, gokcu m, Topuz S, Yildiz F, sakinci m, salman m, ÖZGÜL N, Yuce K, Ayhan A (2020). Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. Uluslararası Hematoloji-Onkoloji Dergisi, 30(1), 54 - 62. 10.4999/uhod.204053
Chicago	Kuru Oguzhan,Akgor Utku,Çakır İlker,tosun özgür aydın,Temel Yuksel Ilkbal,Ulker Volkan,Meydanli Mehmet Mutlu,Sanci Muzaffer,gokcu mehmet,Topuz Samet,Yildiz Ferah,sakinci mehmet,salman mehmet coskun,ÖZGÜL Nejat,Yuce Kunter,Ayhan Ali Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. Uluslararası Hematoloji-Onkoloji Dergisi 30, no.1 (2020): 54 - 62. 10.4999/uhod.204053
MLA	Kuru Oguzhan,Akgor Utku,Çakır İlker,tosun özgür aydın,Temel Yuksel Ilkbal,Ulker Volkan,Meydanli Mehmet Mutlu,Sanci Muzaffer,gokcu mehmet,Topuz Samet,Yildiz Ferah,sakinci mehmet,salman mehmet coskun,ÖZGÜL Nejat,Yuce Kunter,Ayhan Ali Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. Uluslararası Hematoloji-Onkoloji Dergisi, vol.30, no.1, 2020, ss.54 - 62. 10.4999/uhod.204053
AMA	Kuru O,Akgor U,Çakır İ,tosun ö,Temel Yuksel I,Ulker V,Meydanli M,Sanci M,gokcu m,Topuz S,Yildiz F,sakinci m,salman m,ÖZGÜL N,Yuce K,Ayhan A Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. Uluslararası Hematoloji-Onkoloji Dergisi. 2020; 30(1): 54 - 62. 10.4999/uhod.204053
Vancouver	Kuru O,Akgor U,Çakır İ,tosun ö,Temel Yuksel I,Ulker V,Meydanli M,Sanci M,gokcu m,Topuz S,Yildiz F,sakinci m,salman m,ÖZGÜL N,Yuce K,Ayhan A Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study. Uluslararası Hematoloji-Onkoloji Dergisi. 2020; 30(1): 54 - 62. 10.4999/uhod.204053
IEEE	Kuru O,Akgor U,Çakır İ,tosun ö,Temel Yuksel I,Ulker V,Meydanli M,Sanci M,gokcu m,Topuz S,Yildiz F,sakinci m,salman m,ÖZGÜL N,Yuce K,Ayhan A "Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study." Uluslararası Hematoloji-Onkoloji Dergisi, 30, ss.54 - 62, 2020. 10.4999/uhod.204053
ISNAD	Kuru, Oguzhan vd. "Prognostic Factors in Squamous Cell Carcinoma of the Vulva: a Retrospective Multicenter Study". Uluslararası Hematoloji-Onkoloji Dergisi 30/1 (2020), 54-62. https://doi.org/10.4999/uhod.204053