Primer biliyer sirozda çölyak hastalığı birlikteliği

Ünsal, Belkıs; Pakoz, Zehra Betul; vatansever, sezgin

Primer biliyer sirozda çölyak hastalığı birlikteliği

Sezgin Vatansever, (İzmir Kâtip Çelebi Üniversitesi, Atatürk Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İzmir, Türkiye)

Zehra Betül Paköz, (Tepecik Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İzmir, Türkiye)

Belkıs Ünsal (İzmir Kâtip Çelebi Üniversitesi, Atatürk Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İzmir, Türkiye)

Ege Tıp Dergisi

4 0

Yıl: 2019 Cilt: 58 Sayı: 3 Sayfa Aralığı: 246 - 250 Metin Dili: Türkçe İndeks Tarihi: 22-12-2020

Primer biliyer sirozda çölyak hastalığı birlikteliği

Öz:

Amaç: Otoimmun hastalıklar genel olarak birliktelik gösterme eğilimindedirler. Primer biliyer siroza (PBS) dadiğer otoimmun hastalıkların yanı sıra çölyak hastalığı (ÇH) eşlik edebilmektedir. Bu çalışmada PBS’lihastalarda ÇH’nin prevalansı değerlendirildi.Gereç ve Yöntem: Çalışmada Nisan 2006-Aralık 2017 tarihleri arasında tanı alan ve takipli olan 238 PBS’lihasta, kontrol grubu olarak alınan 205 sağlıklı gönüllü ile prospektif olarak karşılaştırıldı. Hastalarda AntiGliadin IgA ve IgG (AGA), Anti Endomisyum IgA ve IgG (EMA) antikorları immunofloresans yöntemi ile bakıldı.Antikorları pozitif saptanan hastalardan duodenum ikinci kısmından biyopsi alındı.Bulgular: Çalışmaya alınan 238 hastanın yaş ortalaması 54,2±12 olup 16’sı erkekti. Kontrol grubundaki 205kişinin 115’i kadın (%56,1), 90’ı erkek ve yaş ortalaması 43,8±14,4’tü. PBS’li 4 hastada AGA ve EMA pozitifliği(%1,7) saptandı. PBS’li hastaların hiçbirinde ÇH semptomları yoktu. On üç (%5,46) hastada ise düşük titredeAGA pozitifliği saptandı. Kontrol grubundaki bir (%0,4) hastada EMA, AGA IgA ve IgG yüksek titrede pozitifsaptandı ve PBS’li grup ile istatistiksel fark saptanmadı (p=0,379). PBS tanısı olan ve EMA, AGA pozitifsaptanan dört hastanın biyopsisinde, bir hastada Marsh 1, bir hastada Marsh 2 ve iki hastada Marsh 3 ileuyumlu duodenum biyopsi bulguları saptandı. EMA ve AGA’sı pozitif olan kontrol grubundaki bir hastanın incebarsak biyopsisi ise Marsh 3 ile uyumluydu.Sonuç: PBS ve ÇH, birbiri ile ilişkili olabilen hastalıklardır. PBS tanılı hastalarda, ÇH açısından seropozitif olanhastaların takibinin ÇH ve komplikasyonlarına de yönelik olması ve tanı konulan hastalara glutensiz diyetinbaşlanması gerekmektedir.

Anahtar Kelime:

Coexisting of coeliac disease in primary biliary cirrhosis

Öz:

Aim: Autoimmune disorders tend to show co-occurrence. Coeliac disease (CD) may accompany primary biliary cirrhosis (PBC) like other autoimmune diseases. In this study, we aimed to evaluate the prevalance of CD in PBC patients. Materials and Methods: Two hundred and thirty-eight patients whom diagnosed as PBC between April 2006- December 2017 and 205 healthy volunteers as control group compared prospectively. AGA IgG, AGA IgA, EMA IgG and EMA IgA results evaluated. Duodenum biopsies were obtained in patients who had positive AGA an EMA results. Results: Median age was 54.2+12 in PBC patients and 43.8+14.4 in control group. Sixteen of 238 PBC patients and 90 of 205 control were male. Four (1.7%) PBC patients had AGA and EMA positivity. None of PBC patients had symptoms for CD. Thirteen (5.46%) patients had AGA positivity with low titration. One (0.4%) healthy control had EMA and AGA positivity and there was no statistical difference between two groups (p=0.379). According to Marsh classification of duodenal biopsies we found one Marsh 1, one Marsh 2 and two Marsh 3 in PBS group. one control who had positive EMA and AGA results showed Marsh 3 in duodenal biopsies. Conclusion: PBC and CD may be associated. PBC patients who are seropositive for CD must be followed according to complications of CD. Gluten-free diet is required for these patients.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	vatansever s, Pakoz Z, Ünsal B (2019). Primer biliyer sirozda çölyak hastalığı birlikteliği. , 246 - 250.
Chicago	vatansever sezgin,Pakoz Zehra Betul,Ünsal Belkıs Primer biliyer sirozda çölyak hastalığı birlikteliği. (2019): 246 - 250.
MLA	vatansever sezgin,Pakoz Zehra Betul,Ünsal Belkıs Primer biliyer sirozda çölyak hastalığı birlikteliği. , 2019, ss.246 - 250.
AMA	vatansever s,Pakoz Z,Ünsal B Primer biliyer sirozda çölyak hastalığı birlikteliği. . 2019; 246 - 250.
Vancouver	vatansever s,Pakoz Z,Ünsal B Primer biliyer sirozda çölyak hastalığı birlikteliği. . 2019; 246 - 250.
IEEE	vatansever s,Pakoz Z,Ünsal B "Primer biliyer sirozda çölyak hastalığı birlikteliği." , ss.246 - 250, 2019.
ISNAD	vatansever, sezgin vd. "Primer biliyer sirozda çölyak hastalığı birlikteliği". (2019), 246-250.

APA	vatansever s, Pakoz Z, Ünsal B (2019). Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi, 58(3), 246 - 250.
Chicago	vatansever sezgin,Pakoz Zehra Betul,Ünsal Belkıs Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi 58, no.3 (2019): 246 - 250.
MLA	vatansever sezgin,Pakoz Zehra Betul,Ünsal Belkıs Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi, vol.58, no.3, 2019, ss.246 - 250.
AMA	vatansever s,Pakoz Z,Ünsal B Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi. 2019; 58(3): 246 - 250.
Vancouver	vatansever s,Pakoz Z,Ünsal B Primer biliyer sirozda çölyak hastalığı birlikteliği. Ege Tıp Dergisi. 2019; 58(3): 246 - 250.
IEEE	vatansever s,Pakoz Z,Ünsal B "Primer biliyer sirozda çölyak hastalığı birlikteliği." Ege Tıp Dergisi, 58, ss.246 - 250, 2019.
ISNAD	vatansever, sezgin vd. "Primer biliyer sirozda çölyak hastalığı birlikteliği". Ege Tıp Dergisi 58/3 (2019), 246-250.