The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions
Yıl: 2020 Cilt: 26 Sayı: 2 Sayfa Aralığı: 133 - 137 Metin Dili: İngilizce DOI: 10.4274/tnd.2020.87405 İndeks Tarihi: 21-12-2020
The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions
Öz: Objective: Platelet activation plays an important role in the development of cerebral arterial occlusion. Mean platelet volume (MPV) and platelet count arereported to be good indicators of platelet activity. The aim of this study was to investigate the relationship between MPV, platelet count, and the plateletlymphocyteratio with endovascular recanalisation success in acute middle cerebral artery (MCA) M1 occlusions.Materials and Methods: Ninety-one patients with acute stroke with MCA M1 occlusions who were treated with endovascular mechanical thrombectomybetween January 2015 and January 2019 were included in the study. Complete blood count, routine biochemical tests, erythrocyte sedimentation rate, clottingtime, aPTT, and INR values of all patients were evaluated. The patients were separated into two groups, those who were recanalized successfully with at leastthrombolysis in cerebral infarction score (TICI) 2b at the first pass, and those whose recanalisation procedure was unsuccessful with ≤TICI 2a.Results: Among the 91 patients included in the study, 61.5% (n=56) were women. The mean age was 62.3±13.4 years. The median National Institute of Healthstroke scale score was 16 (14-19), platelet count was 261.360±78.100/μL, and MPV was 10.2±0.96 fL. There were 48 (52.7%) patients in the poor recanalization(≤ TICI 2a) group and 43 (47.3%) in the successful recanalization (≥ TICI 2b) group after the first pass. There were no statistically significant differences betweenrecanalization success and MPV values, platelet counts, and platelet-lymphocyte ratio (PLR) after the first pass (p values respectively; 0.37, 0.12, and 0.26).Conclusion: Our study revealed that there was no statistical relationship between first-pass thrombectomy success of MCA M1 occlusions and MPV, plateletcount, and PLR values. It is essential to investigate other factors beyond MPV, platelet count, and PLR value in the recanalization success of MCA M1 occlusions.
Anahtar Kelime: Trombektomi ile Tedavi Edilen Orta Serebral Arter Oklüzyonlarında İlk Geçiş Sonunda Rekanalizasyonun Ortalama Trombosit Hacmi, Trombosit Sayısı ve Trombosit Lenfosit Oranı ile İlişkisi
Öz: Amaç: Trombosit aktivasyonu serebral arteriyel oklüzyon gelişmesinde önemli bir role sahiptir. Ortalama trombosit hacminin (MPV) ve trombosit sayısının trombosit aktivitesinin iyi bir göstergesi olduğu bildirilmektedir. Bu çalışmada MPV’nin, trombosit sayısının ve trombosit lenfosit oranının endovasküler yolla tedavi edilen orta serebral arter M1 oklüzyonlarında, ilk geçişte rekanalizasyon ile ilişkisinin araştırılması amaçlandı. Gereç ve Yöntem: Çalışmaya Ocak 2015-Ocak 2019 yılları arasında akut iskemik inme kliniği ile hastaneye başvuran ve orta serebral arter M1 oklüzyonu saptanan, endovasküler mekanik trombektomi ile tedavi edilen 91 hasta dahil edildi. Çalışmaya alınan bütün olguların hemogram, rutin biyokimyasal inceleme, eritrosit sedimentasyon hızı, pıhtılaşma zamanı, aPTT, INR değerleri incelendi. Çalışma sonucunda hastalar ilk geçiş ile en az TICI 2b rekanalize olan ile ilk geçiş sonrası TICI 2a ve altı yeterli rekanalize olmayan olgular olarak iki gruba ayrıldı. Bulgular: Çalışmaya dahil edilen 91 hastanın %61,5 (n=56) kadındı. Tüm hastaların yaş ortalaması 62,3±13,4 idi. Hastaların başvuru anında National Institute of Health stroke skala skoru ortalaması 16 (14-19), trombosit sayısı ortalaması 261,360±78,100/μL, MPV ortalaması 10,2±0,96 fL olarak saptandı. İlk pas ile TICI 2a ve altında rekanalize olmayan grupta 48 (%52,7) ve ilk pas ile TICI 2b ve üzeri rekanalize olan grupta ise 43 (%47,3) hasta saptandı. İlk pas sonrası TICI 2b ve üzeri başarılı rekanalizasyon MPV değeri, trombosit sayısı ve trombosit lenfosit oranı (TLO) ile karşılaştırıldığında istatistiksel olarak anlamlı bir farklılık saptanmadı (sırasıyla p değeri 0,37, 0,12 ve 0,26). Sonuç: Çalışmamızda orta serebral arter M1 tıkanıklıklarının endovasküler tedavi sonucu rekanalizasyonu ile MPV, trombosit sayısı ve trombosit lenfosit oranı değeri arasında istatistiksel olarak anlamlı bir ilişki elde edilememiştir. Sonuç olarak orta serebral arter M1 tıkanıklığının endovasküler tedavi sonucu rekanalizasyonunda MPV, platelet sayısı ve TLO değeri dışı başka faktörlerin araştırılacağı çalışmalara ihtiyaç vardır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ŞENGEZE N, GİRAY S (2020). The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. , 133 - 137. 10.4274/tnd.2020.87405 |
| Chicago | ŞENGEZE Nihat,GİRAY Semih The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. (2020): 133 - 137. 10.4274/tnd.2020.87405 |
| MLA | ŞENGEZE Nihat,GİRAY Semih The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. , 2020, ss.133 - 137. 10.4274/tnd.2020.87405 |
| AMA | ŞENGEZE N,GİRAY S The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. . 2020; 133 - 137. 10.4274/tnd.2020.87405 |
| Vancouver | ŞENGEZE N,GİRAY S The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. . 2020; 133 - 137. 10.4274/tnd.2020.87405 |
| IEEE | ŞENGEZE N,GİRAY S "The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions." , ss.133 - 137, 2020. 10.4274/tnd.2020.87405 |
| ISNAD | ŞENGEZE, Nihat - GİRAY, Semih. "The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions". (2020), 133-137. https://doi.org/10.4274/tnd.2020.87405 |
| APA | ŞENGEZE N, GİRAY S (2020). The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. Türk Nöroloji Dergisi, 26(2), 133 - 137. 10.4274/tnd.2020.87405 |
| Chicago | ŞENGEZE Nihat,GİRAY Semih The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. Türk Nöroloji Dergisi 26, no.2 (2020): 133 - 137. 10.4274/tnd.2020.87405 |
| MLA | ŞENGEZE Nihat,GİRAY Semih The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. Türk Nöroloji Dergisi, vol.26, no.2, 2020, ss.133 - 137. 10.4274/tnd.2020.87405 |
| AMA | ŞENGEZE N,GİRAY S The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. Türk Nöroloji Dergisi. 2020; 26(2): 133 - 137. 10.4274/tnd.2020.87405 |
| Vancouver | ŞENGEZE N,GİRAY S The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions. Türk Nöroloji Dergisi. 2020; 26(2): 133 - 137. 10.4274/tnd.2020.87405 |
| IEEE | ŞENGEZE N,GİRAY S "The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions." Türk Nöroloji Dergisi, 26, ss.133 - 137, 2020. 10.4274/tnd.2020.87405 |
| ISNAD | ŞENGEZE, Nihat - GİRAY, Semih. "The Relationship Between Mean Platelet Volume, Platelet Count, Platelet Lymphocyte Ratio, and Recanalization Success in First-pass Thrombectomy of Middle Cerebral Artery Occlusions". Türk Nöroloji Dergisi 26/2 (2020), 133-137. https://doi.org/10.4274/tnd.2020.87405 |
