Yıl: 2020 Cilt: 26 Sayı: 2 Sayfa Aralığı: 160 - 164 Metin Dili: İngilizce DOI: 10.4274/tnd.2020.29895 İndeks Tarihi: 21-12-2020

The Efficacy of Acyclovir in Childhood Bell’s Palsy

Öz:
Objective: Bell’s palsy is an acute onset, unilateral, self-limiting paresis or paralysis of the facial nerve. The objective in treatment is to increase facial functionsand to accelerate recovery by suppressing this inflammatory process. Steroids and acyclovir (singly or in combination) are used in medical treatment. The objectiveof this study was to determine the clinical profile of Bell’s palsy in childhood and to compare the efficacy of combined acyclovir-prednisolone therapy with thatof prednisolone therapy alone.Materials and Methods: Eighty-six patients diagnosed as having Bell’s palsy were enrolled in the study. All patients were assessed in terms of facial nervedysfunction and recovery time using the House-Brackman Facial Nerve Grading scale (HBFNGS) at initial presentation and at the 15th day, and the first, third,and sixth months. Grade 4 and above was assessed as severe, and lower grades were regarded as mild.Results: The mean age of the patients was 9.5 (±2.4) years. Forty-six (57.6%) patients received prednisolone therapy only, and 34 (42.4%) were started on acombination of oral acyclovir and prednisolone therapy, 29 of whom were in the severe category. Analysis of HBFNGS at one month revealed that the addition ofacyclovir to treatment had no effect on the recovery period. However, combination therapy seems more beneficial in severe cases.Conclusion: Bell’s palsy frequently resolves entirely in childhood, and an acyclovir plus prednisolone combination is not superior to prednisolone alone exceptin severe cases.
Anahtar Kelime:

Çocukluk Çağı Bell Paralizisinde Asiklovirin Etkinliği

Öz:
Amaç: Amaç çocukluk döneminde Bell paralizisinin klinik profilini belirlemek ve kombine asiklovir-prednizolon tedavisinin etkinliğini tekli prednizolon tedavisiyle karşılaştırmak. Gereç ve Yöntem: Çalışmaya Bell paralizisi tanısı konan 86 hasta dahil edildi. Tüm hastalar ilk sunumda ve 15. günde ve birinci, üçüncü ve altıncı aylarda House-Brackman Yüz Sinir Sınıflandırma (HBYS) ölçeği kullanılarak fasiyal sinir disfonksiyonu ve iyileşme süresi açısından değerlendirildi. Dördüncü derece ve üstü şiddetli, düşük dereceler ise hafif olarak kabul edildi. Tüm bulgular, hasta dosyalarının retrospektif incelemesi ile yapıldı. Bulgular: Hastaların yaş ortalaması 9,5 (±2,4) idi. Kırk altı (%57,6) hasta sadece prednizolon tedavisi alırken, 34 (%42,4) hasta kombine tedavi aldığı gözlendi. Kombine tedavi alanların 29’u ağır kategorideydi. Bir aylık HBYS skorlarının analizi, tedaviye asiklovir ilavesinin iyileşme süresi üzerinde bir etkisi olmadığını ortaya koydu. Ancak ciddi olgularda, kombinasyon terapisi daha faydalı görünmektedir. Sonuç: Bell paralizisi sıklıkla çocuklukta tamamen geçer ve asiklovir- prednizolon kombinasyonu, ağır olgular haricinde, tekli prednizolondan daha üstün değildir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Gürbüz G (2020). The Efficacy of Acyclovir in Childhood Bell’s Palsy. , 160 - 164. 10.4274/tnd.2020.29895
Chicago Gürbüz Gürkan The Efficacy of Acyclovir in Childhood Bell’s Palsy. (2020): 160 - 164. 10.4274/tnd.2020.29895
MLA Gürbüz Gürkan The Efficacy of Acyclovir in Childhood Bell’s Palsy. , 2020, ss.160 - 164. 10.4274/tnd.2020.29895
AMA Gürbüz G The Efficacy of Acyclovir in Childhood Bell’s Palsy. . 2020; 160 - 164. 10.4274/tnd.2020.29895
Vancouver Gürbüz G The Efficacy of Acyclovir in Childhood Bell’s Palsy. . 2020; 160 - 164. 10.4274/tnd.2020.29895
IEEE Gürbüz G "The Efficacy of Acyclovir in Childhood Bell’s Palsy." , ss.160 - 164, 2020. 10.4274/tnd.2020.29895
ISNAD Gürbüz, Gürkan. "The Efficacy of Acyclovir in Childhood Bell’s Palsy". (2020), 160-164. https://doi.org/10.4274/tnd.2020.29895
APA Gürbüz G (2020). The Efficacy of Acyclovir in Childhood Bell’s Palsy. Türk Nöroloji Dergisi, 26(2), 160 - 164. 10.4274/tnd.2020.29895
Chicago Gürbüz Gürkan The Efficacy of Acyclovir in Childhood Bell’s Palsy. Türk Nöroloji Dergisi 26, no.2 (2020): 160 - 164. 10.4274/tnd.2020.29895
MLA Gürbüz Gürkan The Efficacy of Acyclovir in Childhood Bell’s Palsy. Türk Nöroloji Dergisi, vol.26, no.2, 2020, ss.160 - 164. 10.4274/tnd.2020.29895
AMA Gürbüz G The Efficacy of Acyclovir in Childhood Bell’s Palsy. Türk Nöroloji Dergisi. 2020; 26(2): 160 - 164. 10.4274/tnd.2020.29895
Vancouver Gürbüz G The Efficacy of Acyclovir in Childhood Bell’s Palsy. Türk Nöroloji Dergisi. 2020; 26(2): 160 - 164. 10.4274/tnd.2020.29895
IEEE Gürbüz G "The Efficacy of Acyclovir in Childhood Bell’s Palsy." Türk Nöroloji Dergisi, 26, ss.160 - 164, 2020. 10.4274/tnd.2020.29895
ISNAD Gürbüz, Gürkan. "The Efficacy of Acyclovir in Childhood Bell’s Palsy". Türk Nöroloji Dergisi 26/2 (2020), 160-164. https://doi.org/10.4274/tnd.2020.29895