Coagulation factors during pregnancy increase natural anticoagulants and fibrinolytic activity also decreased. Besides, due to the growing uterus increased venous return, increased estrogen and progesterone decrease venous atony and mobilization caused by the tendency to thrombosis. A pregnant woman Doppler ultrasound for the diagnosis of deep vein thrombosis, compression ultrasonography or contrast venography. The treatment of anticoagulation is important. However, the use of drugs in pregnancy is a period to be considered. Heparin and its derivatives are used in pregnancy for this reason. Most of the drugs going through to the fetus through the Umbilical cord and can lead to anomalies. However, bleeding, hematoma, thrombocytopenia is vital, such as side effects. It is not possible to prevent postpartum period bleeding is a cause of maternal mortality. Therefore the evaluation and control of the pregnancy must be made regularly. The necessary precautions should be taken against possible complications. This training in the construction, monitoring, and control in the midwife's conception of the right medicine, right patient, the right way, the right time and the right dose of safe medication practice in terms of evaluative principles; the effects and side effects of medications at the same time must be watched.