Yıl: 2019 Cilt: 44 Sayı: Ek Sayı 1 Sayfa Aralığı: 547 - 554 Metin Dili: İngilizce DOI: 10.17826/cumj.558401 İndeks Tarihi: 09-12-2020

Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?

Öz:
Purpose: The aim of this study was to evaluate the role ofpotential autoimmune mechanisms in the pathogenesis ofpreeclampsia by investigating the coexistence of celiacdisease in patients.Material and Methods: Forty women diagnosed withpreeclampsia and forty non-complicated pregnant womenwere enrolled in this prospective, cross-sectional, casecontrol study. Both groups were compared for any allergicdisease symptoms, serological markers of celiac disease,total Ig A and total Ig E levels. Two years later, themothers were questioned about the presence of allergicdiseases in their babies.Results: There was no statistically significant differencebetween the two groups for serological markers of celiacdisease. However, total IgE levels of the preeclampsiagroup were significantly higher than that of the controlgroup.Conclusion: In this study, we did not ascertain anycoexistence of celiac disease and preeclampsia.Nevertheless, we suggest that the increased IgE levels inthe preeclampsia group might be accepted as an indicatorof the immune pathogenesis of preeclampsia and apotential marker for coexisting allergic diseases.
Anahtar Kelime:

Preeklamptik gebeliklerde yüksek IgE seviyeleri, otoimmün patofizyolojiye işaret ediyor mu?

Öz:
Amaç: Bu çalışmada preeklampsi patogenezindeki potansiyel immun mekanizmaların, hastalarda çölyak hastalığı bulunup bulunmamasıyla değerlendirmesi amaçlanmıştır. Gereç ve Yöntem: Kesitsel, vaka kontrolü ve prospektif çalışmaya preeklampsi tanısı konmuş 40 gebe ve 40 komplikasyonu olmayan gebe alındı. Her iki grup alerjik hastalık semptomları, çölyak hastalığına ait serolojik belirteçler, total Ig A ve total Ig E düzeyleri yönünden karşılaştırıldı. İki yıl sonra anneler bebeklerinde alerjik hastalık varlığı açısından sorgulandı. Bulgular: Çölyak hastalığına özgü serolojik belirteçleri açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı bir fark bulunmadı. Ancak, çalışma grubundaki toplam IgE düzeyleri kontrol grubununkilere göre anlamlı olarak daha yüksek olarak gözlendi. Sonuç: Bu çalışmada, çölyak hastalığı ve preeklampsi birlikteliğine ait net olarak herhangi bir sonuç bulunmadı. Ancak, preeklampsi grubunda artmış IgE düzeylerinin, bu hastalığın immün patogenezine ait bir işaret olabileceğini ve eşlik eden alerjik hastalıklara ait potansiyel bir belirteç olarak kabul edilmesini öneriyoruz.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Elmas B, Kıncı M, Gökdemir İ, Alkan A, ALTIN c, EROĞLU E (2019). Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. , 547 - 554. 10.17826/cumj.558401
Chicago Elmas Burak,Kıncı Mehmet Ferdi,Gökdemir İrem Eda,Alkan Afra,ALTIN cihan,EROĞLU Esma Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. (2019): 547 - 554. 10.17826/cumj.558401
MLA Elmas Burak,Kıncı Mehmet Ferdi,Gökdemir İrem Eda,Alkan Afra,ALTIN cihan,EROĞLU Esma Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. , 2019, ss.547 - 554. 10.17826/cumj.558401
AMA Elmas B,Kıncı M,Gökdemir İ,Alkan A,ALTIN c,EROĞLU E Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. . 2019; 547 - 554. 10.17826/cumj.558401
Vancouver Elmas B,Kıncı M,Gökdemir İ,Alkan A,ALTIN c,EROĞLU E Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. . 2019; 547 - 554. 10.17826/cumj.558401
IEEE Elmas B,Kıncı M,Gökdemir İ,Alkan A,ALTIN c,EROĞLU E "Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?." , ss.547 - 554, 2019. 10.17826/cumj.558401
ISNAD Elmas, Burak vd. "Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?". (2019), 547-554. https://doi.org/10.17826/cumj.558401
APA Elmas B, Kıncı M, Gökdemir İ, Alkan A, ALTIN c, EROĞLU E (2019). Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. Cukurova Medical Journal, 44(Ek Sayı 1), 547 - 554. 10.17826/cumj.558401
Chicago Elmas Burak,Kıncı Mehmet Ferdi,Gökdemir İrem Eda,Alkan Afra,ALTIN cihan,EROĞLU Esma Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. Cukurova Medical Journal 44, no.Ek Sayı 1 (2019): 547 - 554. 10.17826/cumj.558401
MLA Elmas Burak,Kıncı Mehmet Ferdi,Gökdemir İrem Eda,Alkan Afra,ALTIN cihan,EROĞLU Esma Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. Cukurova Medical Journal, vol.44, no.Ek Sayı 1, 2019, ss.547 - 554. 10.17826/cumj.558401
AMA Elmas B,Kıncı M,Gökdemir İ,Alkan A,ALTIN c,EROĞLU E Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. Cukurova Medical Journal. 2019; 44(Ek Sayı 1): 547 - 554. 10.17826/cumj.558401
Vancouver Elmas B,Kıncı M,Gökdemir İ,Alkan A,ALTIN c,EROĞLU E Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?. Cukurova Medical Journal. 2019; 44(Ek Sayı 1): 547 - 554. 10.17826/cumj.558401
IEEE Elmas B,Kıncı M,Gökdemir İ,Alkan A,ALTIN c,EROĞLU E "Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?." Cukurova Medical Journal, 44, ss.547 - 554, 2019. 10.17826/cumj.558401
ISNAD Elmas, Burak vd. "Is higher IgE levels in preeclamptic pregnancies suggest autoimmune pathophysiology?". Cukurova Medical Journal 44/Ek Sayı 1 (2019), 547-554. https://doi.org/10.17826/cumj.558401