Yıl: 2020 Cilt: 45 Sayı: 1 Sayfa Aralığı: 22 - 28 Metin Dili: İngilizce DOI: 10.17826/cumj.627506 İndeks Tarihi: 10-12-2020

Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?

Öz:
Purpose: The reason for gastrointestinal system (GIS)motility problems in premature infants is multifactorialand intestinal immaturity is the most importantcontributing factor. To investigate the effect of epidural(EA) or general anesthesia (GA) on GIS function and earlyneonatal morbidity in preterm infants delivered bycesarean section (CS).Materials and Methods: This study was conducted in asingle neonatal intensive care unit (NICU) betweenOctober 2011 and April 2015. Preterms ≤32 weeks and≤1500g who were delivered by CS were enrolled in thisstudy. Mode of anesthesia, demographic, clinicalcharacteristics, first meconium passage time, meconiumobstruction, use of drug for dysmotility and other pretermmorbidities were evaluated.Results: Three hundred and sixty four preterm infantswere enrolled during the study period. Use of drug fordysmotility, time to first meconium passage, andmeconium obstruction rate, were significantly higher in theGA group.Conclusion: This was the first study in the literature thatinvestigated the role of anesthesia methods, effect onpreterm infant GIS motility. Anesthesia modalities duringdelivery may have an effect on GIS function in preterminfants.
Anahtar Kelime:

Obstetrik anestezi yöntemlerinin preterm bebeklerde gastrointestinal sistem fonksiyonu üzerine etkisi var mı?

Öz:
Amaç: Prematüre bebeklerde gastrointestinal sistem (GİS) motilite problemlerinin nedeni multifaktöriyeldir ve intestinal immatürite en önemli faktördür. Sezaryen (C/S) ile doğum yapan prematüre bebeklerde epidural anestezi (EA) veya genel anestezinin (GA) GİS fonksiyonu ve erken neonatal morbidite üzerine etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntem: Bu çalışma Ekim 2011 ile Nisan 2015 arasında tek bir yenidoğan yoğun bakım ünitesinde (YDYBÜ) yapılmıştır. Bu çalışmaya C/S ile doğan ≤32 hafta ve ≤1500 g pretermler dahil edildi. Anestezi yöntemi, demografik, klinik özellikler, ilk mekonyum geçiş zamanı, mekonyum obstrüksiyonu, dismotilite için ilaç kullanımı ve diğer preterm morbiditeleri değerlendirildi. Bulgular: Çalışma döneminde 364 preterm bebek kaydedildi. Dismotilite için ilaç kullanımı, ilk mekonyum geçiş zamanı ve mekonyum obstrüksiyonu oranı GA grubunda anlamlı olarak daha yüksekti. Sonuç: Bu literatürde anestezi yöntemlerinin preterm bebeklerde GİS motilitesi üzerine rolünü araştıra ilk çalışmadır. Doğum sırasındaki anestezi yöntemleri, preterm bebeklerde GİS fonksiyonu üzerinde etkili olabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Hu L, Pan J, Zhang S, Yu J, He K, Shu S et al. Propofol in combination with remifentanil for cesarean section: Placental transfer and effect on mothers and newborns at different induction to delivery intervals. Taiwan J Obstet Gynecol. 2017;56:521-6.
  • 2. American Society of Anesthesiologists Task Force on Obstetric Anesthesia. Practice guidelines for obstetric anesthesia: an updated report by the American Society of Anesthesiologists Task Force on Obstetric Anesthesia. Anesthesiology. 2007;106:843-63.
  • 3. Chooi C, Cox JJ, Lumb RS, Middleton P, Chemali M, Emmett RS et al. Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev. 2017;8:CD002251.
  • 4. Bader AM, Datta S. Anaesthesia for obstetrics. In: Rogers MC, Tinker JH, Covino BG, editors. Principles and Practice of Anaesthesiology. Vol. 2. Toronto: Mosby Year Book. 1993;2065‑2103.
  • 5. Davidson AJ, Disma N, de Graaff JC, Withington DE, Dorris L, Bell G et al. GAS consortium: Neurodevelopmental outcome at 2 years of age after general anaesthesia and awake-regional anaesthesia in infancy (GAS): an international multicentre, randomised controlled trial. Lancet. 2016;387:239-50.
  • 6. McPherson C, Inder T. Perinatal and neonatal use of sedation and analgesia. Semin Fetal Neonatal Med. 2017;22:314-20.
  • 7. Mattei P, Rombeau JL. Review of the pathophysiology and management of postoperative ileus. World J Surg. 2006;30:1382-91.
  • 8. Siddiqui MM, Drewett M, Burge DM. Meconium obstruction of prematurity. Arch Dis Child Fetal Neonatal Ed. 2012;97:F147-150.
  • 9. Tachecí I, Květina J, Kuneš M, Pavlík M, Kopáčová M, Černý V et al. The effect of general anaesthesia on gastric myoelectric activity in experimental pigs. BMC Gastroenterol. 2013;13:48.
  • 10. de Boer HD, Detriche O, Forget P. Opioid-related side effects: Postoperative ileus, urinary retention, nausea and vomiting, and shivering. A review of the literature. Best Pract Res Clin Anaesthesiol. 2017;31:499-504.
  • 11. Boscan P, Cochran S, Monnet E, Webb C, Twedt D. Effect of prolonged general anesthesia with sevoflurane and laparoscopic surgery on gastric and small bowel propulsive motility and pH in dogs. Vet Anaesth Analg. 2014;41:73-81.
  • 12. Desmet M, Vander Cruyssen P, Pottel H, Carlier S, Devriendt D, Van Rooy F et al. The influence of propofol and sevoflurane on intestinal motility during laparoscopic surgery. Acta Anaesthesiol Scand. 2016;60:335-42.
  • 13. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L et al. Neonatal necrotizing enterocolitis. Therapeutic decision based upon clinical staging. An Surg. 1978;187:1–7.
  • 14. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr. 1978;187:1-7.
  • 15. International Committee for the Classification of Retinopathy of Prematurity. The international classification of retinopathy of prematurity revisited. Arch Ophthalmol. 2005;123:991–9.
  • 16. Northway Jr WH, Rosan RC, Porter DY. Pulmonary disease following respiratory therapy of hyalinemembrane disease. Bronchopulmonary dysplasia. N Engl J Med. 1967;276:357e68.
  • 17. Rickham PP, Boeckman CR. Neonatal meconium obstruction in the absence of mucoviscidosis. Am J Surg. 1965;109:173–7.
  • 18. Dailly E, Drouineau MH, Gournay V, Rozé JC, Jolliet P. Population pharmacokinetics of domperidone in preterm neonates. Eur J Clin Pharmacol. 2008;64:1197-2000.
  • 19. Soltanifar S, Russell R. The National Institute for Health and Clinical Excellence (NICE) guidelines for caesarean section, 2011 update: implications for the anaesthetist. Int J Obstet Anesth. 2012;21:264-72.
  • 20. Merchant R, Chartrand D, Dain S, Dobson G, Kurrek MM, Lagacé A et al.; Canadian Anesthesiologists’ Society. Guidelines to the practice of anesthesia-- revised edition 2015. Can J Anaesth. 2015;62:54-67.
  • 21. Nwafor MI, Aniebue UU, Nwankwo TO, Onyeka TC, Okafor VU. Perinatal outcome of preterm cesarean section in a resource-limited centre: a comparison between general anaesthesia and subarachnoid block. Niger J Clin Pract. 2014;17:613- 8.
  • 22. Wang Q, Zheng SX, Ni YF, Lu YY, Zhang B, Lian QQ et al. The effect of labor epidural analgesia on maternal-fetal outcomes: a retrospective cohort study. Arch Gynecol Obstet. 2018;298:89-96.
  • 23. Noskova P, Blaha J, Bakhouche H, Kubatova J, Ulrichova J, Marusicova P et al. Neonatal effect of remifentanil in general anaesthesia for caesarean section: a randomized trial. BMC Anesthesiol. 2015;15:38.
  • 24. Chattopadhyay S, Das A, Pahari S. Fetomaternal outcome in severe preeclamptic women undergoing emergency cesarean section under either general or spinal anesthesia. J Pregnancy. 2014;2014:325098.
  • 25. Afolabi BB, Lesi FE, Merah NA. Regional versus general anaesthesia for caesarean section. Cochrane Database Syst Rev. 2006;(4):CD004350.
  • 26. Havas F, Orhan Sungur M, Yenigün Y, Karadeniz M, Kılıç M, Özkan Seyhan T. Spinal anesthesia for elective cesarean section is associated with shorter hospital stay compared to general anesthesia. Agri. 2013;25:55-63.
  • 27. Ozden Omaygenc D, Dogu T, Omaygenc MO, Ozmen F, Albayrak MD, Babur Guler G et al. Type of anesthesia affects neonatal wellbeing and frequency of transient tachypnea in elective cesarean sections. J Matern Fetal Neonatal Med. 2015;28:568-72.
  • 28. Saygı Aİ, Özdamar Ö, Gün İ, Emirkadı H, Müngen E, Akpak YK. Comparison of maternal and fetal outcomes among patients undergoing cesarean section under general and spinal anesthesia: a randomized clinical trial. Sao Paulo Med J. 2015;133:227-34.
  • 29. Heesen M, Böhmer J, Klöhr S, Hofmann T, Rossaint R, Straube S. The effect of adding a background infusion to patient-controlled epidural labor analgesia on labor, maternal, and neonatal outcomes: a systematic review and meta-analysis. Anesth Analg. 2015;121:149-58.
  • 30. Shyken JM, Smeltzer JS, Baxi LV, Blakemore KJ, Ambrose SE, Petrie RH. A comparison of the effectof epidural, general and no anesthesia on funic acid–base values by stage of labor and type of delivery. Am J Obstet Gynecol. 1990;163:802–7.
  • 31. Mattingly JE, D’Alessio J, Ramanathan J. Effects of obstetric analgesic and anesthetics on the neonate: a review. Paediatr Drugs. 2003;5:615–27.
  • 32. Laudenbach V, Mercier FJ, Rozé JC, Larroque B, Ancel PY, Kaminski M et al. Epipage Study Group. Anaesthesia mode for cesarean section and mortality in very preterm infants: An epidemiologic study in the EPIPAGE cohort. Int J Obstet Anesth. 2009;18:142‑9.
  • 33. Maayan-Metzger A, Schushan-Eisen I, Todris L, Etchin A, Kuint J. Maternal hypotension during elective cesarean section and shortterm neonatal outcome. Am J Obstet Gynecol. 2010;202:56.e1-5.
  • 34. Urmey WF. Regional Anaesthesia Topic of the Week: Obstetric Anaesthesia. New York: School of Regional Anaesthesia. 2009;21:47.
  • 35. Trevor AJ, Miller RD. General anaesthetics. In: Katzung BG, editor. Basic and Clinical Pharmacology. 6th ed. East Norwalk: Appleton and Lange. 1995:381‑94.
  • 36. Somri M, Matter I, Parisinos CA, Shaoul R, Mogilner JG, Bader D et al. The effect of combined spinalepidural anesthesia versus general anesthesia on the recovery time of intestinal function in young infants undergoing intestinal surgery: a randomized, prospective, controlled trial. J Clin Anesth. 2012;24:439-45.
  • 37. Behm B, Stollman N. Postoperative ileus: etiologies and interventions. Clin Gastroenterol Hepatol. 2003;1:71-80.
  • 38. De Corte W, Delrue H, Vanfleteren LJ, Dutré PE, Pottel H, Devriendt DK et al. Randomized clinical trial on the influence of anaesthesia protocol on intestinal motility during laparoscopic surgery requiring small bowel anastomosis. Br J Surg. 2012;99:1524-9.
  • 39. Garza-Cox S, Keeney SE, Angel CA, Thompson LL, Swischuk LE. Meconium obstruction in the very low birth weight premature infant. Pediatrics. 2004;114:285–90.
APA Cakir U, YILDIZ D, Kahvecioğlu D, Okulu E, ALAN S, Erdeve Ö, Arsan S, Atasay B (2020). Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. , 22 - 28. 10.17826/cumj.627506
Chicago Cakir Ufuk,YILDIZ DURAN,Kahvecioğlu Dilek,Okulu Emel,ALAN Serdar,Erdeve Ömer,Arsan Saadet,Atasay Begüm Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. (2020): 22 - 28. 10.17826/cumj.627506
MLA Cakir Ufuk,YILDIZ DURAN,Kahvecioğlu Dilek,Okulu Emel,ALAN Serdar,Erdeve Ömer,Arsan Saadet,Atasay Begüm Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. , 2020, ss.22 - 28. 10.17826/cumj.627506
AMA Cakir U,YILDIZ D,Kahvecioğlu D,Okulu E,ALAN S,Erdeve Ö,Arsan S,Atasay B Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. . 2020; 22 - 28. 10.17826/cumj.627506
Vancouver Cakir U,YILDIZ D,Kahvecioğlu D,Okulu E,ALAN S,Erdeve Ö,Arsan S,Atasay B Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. . 2020; 22 - 28. 10.17826/cumj.627506
IEEE Cakir U,YILDIZ D,Kahvecioğlu D,Okulu E,ALAN S,Erdeve Ö,Arsan S,Atasay B "Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?." , ss.22 - 28, 2020. 10.17826/cumj.627506
ISNAD Cakir, Ufuk vd. "Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?". (2020), 22-28. https://doi.org/10.17826/cumj.627506
APA Cakir U, YILDIZ D, Kahvecioğlu D, Okulu E, ALAN S, Erdeve Ö, Arsan S, Atasay B (2020). Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. Cukurova Medical Journal, 45(1), 22 - 28. 10.17826/cumj.627506
Chicago Cakir Ufuk,YILDIZ DURAN,Kahvecioğlu Dilek,Okulu Emel,ALAN Serdar,Erdeve Ömer,Arsan Saadet,Atasay Begüm Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. Cukurova Medical Journal 45, no.1 (2020): 22 - 28. 10.17826/cumj.627506
MLA Cakir Ufuk,YILDIZ DURAN,Kahvecioğlu Dilek,Okulu Emel,ALAN Serdar,Erdeve Ömer,Arsan Saadet,Atasay Begüm Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. Cukurova Medical Journal, vol.45, no.1, 2020, ss.22 - 28. 10.17826/cumj.627506
AMA Cakir U,YILDIZ D,Kahvecioğlu D,Okulu E,ALAN S,Erdeve Ö,Arsan S,Atasay B Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. Cukurova Medical Journal. 2020; 45(1): 22 - 28. 10.17826/cumj.627506
Vancouver Cakir U,YILDIZ D,Kahvecioğlu D,Okulu E,ALAN S,Erdeve Ö,Arsan S,Atasay B Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?. Cukurova Medical Journal. 2020; 45(1): 22 - 28. 10.17826/cumj.627506
IEEE Cakir U,YILDIZ D,Kahvecioğlu D,Okulu E,ALAN S,Erdeve Ö,Arsan S,Atasay B "Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?." Cukurova Medical Journal, 45, ss.22 - 28, 2020. 10.17826/cumj.627506
ISNAD Cakir, Ufuk vd. "Do obstetric anesthesia methods have an impact on gastrointestinal system function in preterm infants?". Cukurova Medical Journal 45/1 (2020), 22-28. https://doi.org/10.17826/cumj.627506