Yıl: 2020 Cilt: 45 Sayı: 1 Sayfa Aralığı: 200 - 207 Metin Dili: İngilizce DOI: 10.17826/cumj.638611 İndeks Tarihi: 10-12-2020

The frequency of avascular necrosis in juvenile systemic lupus erythematosus

Öz:
Purpose: Avascular necrosis (AVN) is a debilitatingcomplication of juvenile systemic lupus erythematosus(jSLE). The aim of this study was to evaluate the frequencyand clinical characteristics of patients with AVN in jSLEfrom a single center.Material and Methods: Fifty-eight jSLE patientsdiagnosed according to the American College ofRheumatology classification criteria were included in thisretrospective study. Disease activity of jSLE patients wasmeasured by SLE Disease Activity Index-2K (SLEDAI2K), organ damage was determined by the pediatricversion of the systemic lupus international collaboratingclinics/American College of Rheumatology damage index(pedSDI) at last visit.Results: Among 58 jSLE patients, the female patientsaccounted for 86.2% (n=50). Mean baseline SLEDAI-2Kscore was 21.47±8.96. The number of patients with at leastone damage item of pedSDI was 24 (41.4%), in which 5patients (8.6%) had AVN. There were no statisticaldifferences between the groups except baselinecomplement 3 (C3) level was significantly lower in patientswith AVN.Conclusion: Baseline low C3 level might be a predictorfor AVN development in jSLE patients.There is unmetneed for multicenter studies investigating possible riskfactors of AVN in jSLE patients.
Anahtar Kelime:

Çocukluk çağı başlangıçlı sistemik lupus eritematozus hastalarında avasküler nekrozis sıklığı

Öz:
Amaç: Avasküler nekrozis (AVN), çocukluk çağı başlangıçlı sistemik lupus eritematozusun (jSLE) yıkıcı bir komplikasyonudur. Tek merkezden yapılan bu çalışmanın amacı jSLE hastalarında AVN sıklığını ve bu hastaların klinik özelliklerini belirlemektir. Gereç ve Yöntem: Amerikan Romatoloji Koleji’nin sınıflama kriterlerine göre tanı almış 58 jSLE hastası bu geriye dönük çalışmaya dahil edildi. jSLE hastalarının hastalık aktiviteleri SLE hastalık aktivite indeksi baz alınarak (SLEDAI-2K) ölçüldü. Organ hasarı Amerikan Romatoloji Koleji’nin SLE hastalarında uyguladığı hasar indeksinin çocukluklardaki versiyonu kullanılarak son muayenede belirlendi. Bulgular: Elli sekiz jSLE hastasının %86,2 (50)’si kız hastaydı. Ortalama bazal SLEDAI-2K skoru 21,47±8,96 idi. En az bir organda hasarı olan hasta sayısı 24 (%41,4) idi, bunlardan 5 tanesinde (%8,6) AVN vardı. AVN olan ve olmayan hastalar arasında çeşitli değikenlere göre istatistiksel anlamlı bir farklılık saptanmadı. Sadece bazal kompleman 3 (C3) düzeyi AVN hastalarında, AVN olmayan hastalara göre anlamlı olarak düşüktü. Sonuç: Bazal düşük C3 düzeyi jSLE hastalarında AVN gelişimini tahmin etmede ön görücü olabilir. jSLE hastalarında AVN gelişimi için muhtemel risk faktörlerini inceleyen çok merkezli çalışmalara ihtiyaç vardır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Balci S, Kisla Ekinci R, PISKIN F, Melek E, Atmış B, ÖZCAN D, Altintas D, Karabay Bayazit A (2020). The frequency of avascular necrosis in juvenile systemic lupus erythematosus. , 200 - 207. 10.17826/cumj.638611
Chicago Balci Sibel,Kisla Ekinci Rabia Miray,PISKIN FERHAT CAN,Melek Engin,Atmış Bahriye,ÖZCAN Dilek,Altintas Derya Ufuk,Karabay Bayazit Aysun The frequency of avascular necrosis in juvenile systemic lupus erythematosus. (2020): 200 - 207. 10.17826/cumj.638611
MLA Balci Sibel,Kisla Ekinci Rabia Miray,PISKIN FERHAT CAN,Melek Engin,Atmış Bahriye,ÖZCAN Dilek,Altintas Derya Ufuk,Karabay Bayazit Aysun The frequency of avascular necrosis in juvenile systemic lupus erythematosus. , 2020, ss.200 - 207. 10.17826/cumj.638611
AMA Balci S,Kisla Ekinci R,PISKIN F,Melek E,Atmış B,ÖZCAN D,Altintas D,Karabay Bayazit A The frequency of avascular necrosis in juvenile systemic lupus erythematosus. . 2020; 200 - 207. 10.17826/cumj.638611
Vancouver Balci S,Kisla Ekinci R,PISKIN F,Melek E,Atmış B,ÖZCAN D,Altintas D,Karabay Bayazit A The frequency of avascular necrosis in juvenile systemic lupus erythematosus. . 2020; 200 - 207. 10.17826/cumj.638611
IEEE Balci S,Kisla Ekinci R,PISKIN F,Melek E,Atmış B,ÖZCAN D,Altintas D,Karabay Bayazit A "The frequency of avascular necrosis in juvenile systemic lupus erythematosus." , ss.200 - 207, 2020. 10.17826/cumj.638611
ISNAD Balci, Sibel vd. "The frequency of avascular necrosis in juvenile systemic lupus erythematosus". (2020), 200-207. https://doi.org/10.17826/cumj.638611
APA Balci S, Kisla Ekinci R, PISKIN F, Melek E, Atmış B, ÖZCAN D, Altintas D, Karabay Bayazit A (2020). The frequency of avascular necrosis in juvenile systemic lupus erythematosus. Cukurova Medical Journal, 45(1), 200 - 207. 10.17826/cumj.638611
Chicago Balci Sibel,Kisla Ekinci Rabia Miray,PISKIN FERHAT CAN,Melek Engin,Atmış Bahriye,ÖZCAN Dilek,Altintas Derya Ufuk,Karabay Bayazit Aysun The frequency of avascular necrosis in juvenile systemic lupus erythematosus. Cukurova Medical Journal 45, no.1 (2020): 200 - 207. 10.17826/cumj.638611
MLA Balci Sibel,Kisla Ekinci Rabia Miray,PISKIN FERHAT CAN,Melek Engin,Atmış Bahriye,ÖZCAN Dilek,Altintas Derya Ufuk,Karabay Bayazit Aysun The frequency of avascular necrosis in juvenile systemic lupus erythematosus. Cukurova Medical Journal, vol.45, no.1, 2020, ss.200 - 207. 10.17826/cumj.638611
AMA Balci S,Kisla Ekinci R,PISKIN F,Melek E,Atmış B,ÖZCAN D,Altintas D,Karabay Bayazit A The frequency of avascular necrosis in juvenile systemic lupus erythematosus. Cukurova Medical Journal. 2020; 45(1): 200 - 207. 10.17826/cumj.638611
Vancouver Balci S,Kisla Ekinci R,PISKIN F,Melek E,Atmış B,ÖZCAN D,Altintas D,Karabay Bayazit A The frequency of avascular necrosis in juvenile systemic lupus erythematosus. Cukurova Medical Journal. 2020; 45(1): 200 - 207. 10.17826/cumj.638611
IEEE Balci S,Kisla Ekinci R,PISKIN F,Melek E,Atmış B,ÖZCAN D,Altintas D,Karabay Bayazit A "The frequency of avascular necrosis in juvenile systemic lupus erythematosus." Cukurova Medical Journal, 45, ss.200 - 207, 2020. 10.17826/cumj.638611
ISNAD Balci, Sibel vd. "The frequency of avascular necrosis in juvenile systemic lupus erythematosus". Cukurova Medical Journal 45/1 (2020), 200-207. https://doi.org/10.17826/cumj.638611