Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum
Yıl: 2020 Cilt: 7 Sayı: 3 Sayfa Aralığı: 204 - 210 Metin Dili: İngilizce DOI: 10.4274/jus.galenos.2020.3363 İndeks Tarihi: 10-12-2020
Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum
Öz: Objective: Resistin is an important factor in the pathogenesis of obesity-induced insulin resistance and endothelial dysfunction-mediatedcardiovascular system diseases. Endothelial dysfunction is one of the most important causes of erectile dysfunction. Polyphenol resveratrol hasseveral pharmacological functions, such as preventing endothelial dysfunction and inducing endothelium-dependent vascular relaxation via redoxregulation and nitric oxide production. The present study tested the hypothesis that resveratrol restores endothelium-mediated responses that aredisrupted by resistin.Materials and Methods: After a 24 h incubation period of tissues with resistin, endothelium-dependent and independent relaxation responses andnicotinamide adenine dinucleotide phosphate (NADPH) oxidase level were evaluated in the presence and absence of resveratrol in rabbit corpuscavernosum (CC).Results: Resistin caused no impairment in the endothelium-dependent and -independent relaxation responses. In the presence of resistin, NADPHoxidase levels increased by 28% in the CC tissues. However, the difference was not statistically significant. Resveratrol administration caused asignificant decrease in NADPH oxidase activity in the resistin-treated group compared with the resistin-alone group.Conclusion: Resistin caused no changes in the functional responses of CC and NADPH oxidase activity, but resveratrol incubation significantlyreduced NADPH oxidase activity in penile tissue. Based on the results of the study, resveratrol may be a treatment target under conditions in whichNADPH oxidase activity is increased in penile tissue. In line with the results of this study, the effect of resistin on CC must be investigated at differentconcentrations and incubation times.
Anahtar Kelime: Resistinin Tavşan Korpus Kavernosumundaki Etkisi Üzerine Resveratrolün Rolü
Öz: Amaç: Resistin, obezite ile indüklenen insülin direnci ve endotelyal disfonksiyon aracılı kardiyovasküler sistem hastalıklarının patogenezinde önemli bir faktör olarak bilinmektedir. Endotel disfonksiyonu, erektil disfonksiyonun en önemli nedenlerinden biridir. Polifenol resveratrol, endotel disfonksiyonu önlemek, redoks regülasyonu ve nitrik oksit üretimini sağlayarak endotel bağımlı vasküler gevşemeyi indüklemek gibi çeşitli farmakolojik fonksiyonlara sahiptir. Bu çalışma ile, resistin ile bozulan endotel aracılı yanıtları resveratrol düzeltir, hipotezi test edilmiştir. Gereç ve Yöntem: Dokuların resistin ile 24 saatlik inkübasyon periyodunun ardından, tavşan korpus kavernosumunda (KK), resveratrol varlığında ve yokluğunda, endotel bağımlı ve bağımsız gevşeme yanıtları, nikotin amid adenin dinükleotid fosfat (NADPH) oksidaz seviyesi değerlendirildi. Bulgular: Resistin, endotel-bağımlı ve bağımsız gevşeme yanıtlarını bozmadı. Resistin varlığında, NADPH oksidaz seviyeleri CC dokularında %28 arttı, ancak fark istatistiksel olarak anlamlı değildi. Resveratrol varlığında resistin uygulanan gruptaki NADPH oksidaz aktivitesinde, tek başına resistin grubuna oranla, anlamlı derecede azalma oldu. Sonuç: Resistin, KK’de fonksiyonel yanıtlar ve NADPH oksidaz aktivitesinde herhangi bir değişikliğe neden olmadı, ancak resveratrol inkübasyonu penil dokudaki NADPH oksidaz aktivitesini anlamlı olarak azalttı. Çalışmanın sonuçlarına dayanarak, resveratrolün, penil dokuda NADPH oksidaz aktivitesinin arttığı koşullarda bir tedavi hedefi olabileceği düşünülmektedir. Bu çalışmanın sonuçları doğrultusunda, resistinin KK üzerindeki etkisinin farklı konsantrasyonlarda ve farklı inkübasyon sürelerinde araştırılması gereklidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Gungor T, Acar-Sahan S, Kahraman E, Bozkurt O, DURMUŞ N (2020). Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. , 204 - 210. 10.4274/jus.galenos.2020.3363 |
| Chicago | Gungor Turkan,Acar-Sahan Selin,Kahraman Erkan,Bozkurt Ozan,DURMUŞ Nergiz Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. (2020): 204 - 210. 10.4274/jus.galenos.2020.3363 |
| MLA | Gungor Turkan,Acar-Sahan Selin,Kahraman Erkan,Bozkurt Ozan,DURMUŞ Nergiz Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. , 2020, ss.204 - 210. 10.4274/jus.galenos.2020.3363 |
| AMA | Gungor T,Acar-Sahan S,Kahraman E,Bozkurt O,DURMUŞ N Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. . 2020; 204 - 210. 10.4274/jus.galenos.2020.3363 |
| Vancouver | Gungor T,Acar-Sahan S,Kahraman E,Bozkurt O,DURMUŞ N Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. . 2020; 204 - 210. 10.4274/jus.galenos.2020.3363 |
| IEEE | Gungor T,Acar-Sahan S,Kahraman E,Bozkurt O,DURMUŞ N "Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum." , ss.204 - 210, 2020. 10.4274/jus.galenos.2020.3363 |
| ISNAD | Gungor, Turkan vd. "Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum". (2020), 204-210. https://doi.org/10.4274/jus.galenos.2020.3363 |
| APA | Gungor T, Acar-Sahan S, Kahraman E, Bozkurt O, DURMUŞ N (2020). Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. Journal of Urological Surgery, 7(3), 204 - 210. 10.4274/jus.galenos.2020.3363 |
| Chicago | Gungor Turkan,Acar-Sahan Selin,Kahraman Erkan,Bozkurt Ozan,DURMUŞ Nergiz Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. Journal of Urological Surgery 7, no.3 (2020): 204 - 210. 10.4274/jus.galenos.2020.3363 |
| MLA | Gungor Turkan,Acar-Sahan Selin,Kahraman Erkan,Bozkurt Ozan,DURMUŞ Nergiz Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. Journal of Urological Surgery, vol.7, no.3, 2020, ss.204 - 210. 10.4274/jus.galenos.2020.3363 |
| AMA | Gungor T,Acar-Sahan S,Kahraman E,Bozkurt O,DURMUŞ N Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. Journal of Urological Surgery. 2020; 7(3): 204 - 210. 10.4274/jus.galenos.2020.3363 |
| Vancouver | Gungor T,Acar-Sahan S,Kahraman E,Bozkurt O,DURMUŞ N Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum. Journal of Urological Surgery. 2020; 7(3): 204 - 210. 10.4274/jus.galenos.2020.3363 |
| IEEE | Gungor T,Acar-Sahan S,Kahraman E,Bozkurt O,DURMUŞ N "Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum." Journal of Urological Surgery, 7, ss.204 - 210, 2020. 10.4274/jus.galenos.2020.3363 |
| ISNAD | Gungor, Turkan vd. "Role of Resveratrol on the Effect of Resistin in Rabbit Corpus Cavernosum". Journal of Urological Surgery 7/3 (2020), 204-210. https://doi.org/10.4274/jus.galenos.2020.3363 |
