Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey
Yıl: 2020 Cilt: 45 Sayı: 2 Sayfa Aralığı: 533 - 540 Metin Dili: İngilizce DOI: 10.17826/cumj.672199 İndeks Tarihi: 11-12-2020
Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey
Öz: Purpose: This study aims to evaluate the epidemiological,demographic and clinical characteristics, and prognosticfactors of the patients with non-Hodgkin lymphomas(NHL).Materials and Methods: All patients diagnosed withNHL at the Department of Hematology of InonuUniversity Faculty of Medicine (Turkey) between 2000 and2016 were evaluated for this study. Only patients olderthan 18 years were included in the study. Characteristicswere evaluated by reviewing patients’ recordsretrospectively.Results: Of the 386 patients studied, 242 (62.7%) weremale and 144 (37.3%) were female and the overall medianage was 53 years (range: 18–92). The most commonhistological subtype of NHL was diffuse large B-celllymphoma (DLBCL) (46.9%). In univariate analyses,advanced stage (III-IV), high-intermediate to high riskcategory disease based on IPI score, bone marrowinvolvement at diagnosis, haemoglobin levels below 10g/dL, increased LDH levels, primary nodal involvement,the presence of B symptoms, the exigency of autologousbone marrow transplant, and not receiving rituximabbased chemotherapy regimens as the primary treatmentwere all associated with shorter overall survival.Conclusion: The prevalence, clinical characteristics,histopathological subtypes, treatment responses, andoverall survival rates may differ because NHL is aheterogeneous disease group and may vary according to ageographical area. Therefore, treatment should beindividualized according to disease subtype.
Anahtar Kelime: Türkiye'nin doğusunda non-Hodgkin lenfoma hastalarının klinik ve patolojik özellikleri
Öz: Amaç: Bu çalışmada non-Hodgkin lenfoma (NHL) hastalarının epidemiyolojik, demografik, klinik ve prognostik özelliklerini araştırmayı amaçladık. Gereç ve Yöntem: İnönü Üniversitesi Tıp Fakültesi Hematoloji kliniğinde 2000 ile 2016 yılları arasında NHL tanısı ile takipli hastalar çalışmaya alındı. Çalışmaya 18 yaşından büyük hastalar dâhil edildi. Hasta özellikleri, kayıtlar retrospektif olarak gözden geçirilerek değerlendirildi. Bulgular: Çalışmaya alınan 386 hastanın 242’si (%62.7) erkek, 144’ü (%37.3) kadın, ve tüm hastalarda ortanca yaş 53 idi. En sık NHL alt tipi Diffüz Büyük B Hücreli Lenfoma (DBBHL) (46.9) idi. Tek değişkenli analizde, hastaların ileri evrede (Evre III-IV) olması, IPI skoruna göre yüksek-orta ve yüksek riskli kategoride olması, kemik iliği tutulumu olması, hemoglobin düzeyinin 10 gr/dl’nin altında olması, LDH düzeyinin normalin üzerinde olması, primer tutulumunun nodal olması, B semptomların varlığı, otolog kemik iliği yapılması zorunluluğu ve birincil tedavi olarak rituximab bazlı kemoterapi rejimlerini almaması daha kısa genel sağkalım ile ilişkili bulundu. Sonuç: NHL hastalığının insidansı, klinik özellikleri, histopatolojik alt tipleri, tedavi yanıtları ve genel sağkalım oranları coğrafi bölgelere göre farklılıklar gösterebilmektedir. Bu nedenle tedavi hastalık alt tip dağılımına göre bireyselleştirilmelidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Doğan A, Yildirim Dogan N, ERKURT M, Ekinci O, KUKU I, KAYA H (2020). Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. , 533 - 540. 10.17826/cumj.672199 |
| Chicago | Doğan Ali,Yildirim Dogan Narin,ERKURT MEHMET ALI,Ekinci Omer,KUKU IRFAN,KAYA Hasan Emin Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. (2020): 533 - 540. 10.17826/cumj.672199 |
| MLA | Doğan Ali,Yildirim Dogan Narin,ERKURT MEHMET ALI,Ekinci Omer,KUKU IRFAN,KAYA Hasan Emin Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. , 2020, ss.533 - 540. 10.17826/cumj.672199 |
| AMA | Doğan A,Yildirim Dogan N,ERKURT M,Ekinci O,KUKU I,KAYA H Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. . 2020; 533 - 540. 10.17826/cumj.672199 |
| Vancouver | Doğan A,Yildirim Dogan N,ERKURT M,Ekinci O,KUKU I,KAYA H Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. . 2020; 533 - 540. 10.17826/cumj.672199 |
| IEEE | Doğan A,Yildirim Dogan N,ERKURT M,Ekinci O,KUKU I,KAYA H "Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey." , ss.533 - 540, 2020. 10.17826/cumj.672199 |
| ISNAD | Doğan, Ali vd. "Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey". (2020), 533-540. https://doi.org/10.17826/cumj.672199 |
| APA | Doğan A, Yildirim Dogan N, ERKURT M, Ekinci O, KUKU I, KAYA H (2020). Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. Cukurova Medical Journal, 45(2), 533 - 540. 10.17826/cumj.672199 |
| Chicago | Doğan Ali,Yildirim Dogan Narin,ERKURT MEHMET ALI,Ekinci Omer,KUKU IRFAN,KAYA Hasan Emin Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. Cukurova Medical Journal 45, no.2 (2020): 533 - 540. 10.17826/cumj.672199 |
| MLA | Doğan Ali,Yildirim Dogan Narin,ERKURT MEHMET ALI,Ekinci Omer,KUKU IRFAN,KAYA Hasan Emin Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. Cukurova Medical Journal, vol.45, no.2, 2020, ss.533 - 540. 10.17826/cumj.672199 |
| AMA | Doğan A,Yildirim Dogan N,ERKURT M,Ekinci O,KUKU I,KAYA H Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. Cukurova Medical Journal. 2020; 45(2): 533 - 540. 10.17826/cumj.672199 |
| Vancouver | Doğan A,Yildirim Dogan N,ERKURT M,Ekinci O,KUKU I,KAYA H Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey. Cukurova Medical Journal. 2020; 45(2): 533 - 540. 10.17826/cumj.672199 |
| IEEE | Doğan A,Yildirim Dogan N,ERKURT M,Ekinci O,KUKU I,KAYA H "Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey." Cukurova Medical Journal, 45, ss.533 - 540, 2020. 10.17826/cumj.672199 |
| ISNAD | Doğan, Ali vd. "Clinical and pathological characteristics of patients with non-Hodgkin lymphoma cases in Eastern Turkey". Cukurova Medical Journal 45/2 (2020), 533-540. https://doi.org/10.17826/cumj.672199 |
