Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 11 - 16 Metin Dili: İngilizce DOI: 10.21613/GORM.2019.970 İndeks Tarihi: 18-12-2020

The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women

Öz:
OBJECTIVE: Obesity is a very common and important health problem and it has become widespreadall over the world. Fat tissue is one of the major endocrine organs. Subcutaneous adipose tissue is associatedwith many diseases such as coronary artery disease, metabolic syndrome, diabetes, impairedlipid profile. Pregnancy is a special condition with metabolic changes involving all systems. We aimed toinvestigate the relationship and correlation between abdominal fat and HbA1c because of the specificmetabolic conditions in pregnancy.STUDY DESIGN: This is a retrospective study. Ninety-nine (n=99) pregnant women between the agesof 20 and 40 were included in the present study. They have not any other chronic diseases.Ultrasonography was performed between 16.-28. weeks. Abdominal subcutaneous fat tissue was measuredduring 16-28 weeks of pregnancy. Routine biochemical parameters and HbA1c were evaluated.RESULTS: Subcutaneous fat tissue had a positive correlation with metabolic parameters such as weightand BMI, and a negative correlation with vitamin D level. There is a positive strong correlation withHbA1c level. There was not any correlation between HbA1c and metabolic parameters like triglyceride,LDL, HDL, and cholesterol.CONCLUSION: There was a strong positive correlation between abdominal subcutaneous fat tissuethickness and HbA1c. However, we didn’t find any correlation between infant weight and metabolic parameters.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Onat A. Türkiye’de Obezitenin Kardiyovasküler Hasta - lıklara Etkisi. Turk Kardiyol Dern Ars. 2003;31(5):279- 89.
  • 2. Fukuhara A, Matsuda M, Nishizawa M, Segawa K, Tanaka M, Kishimoto K et al. Visfatin a protein secreted by visceral fat that mimics the effects of insulin. Science 2005;307(5708): 426-30.
  • 3. Viengchareun S, Zennaro MC, Pascual-Le Tallec L, Lombes M. Brown adipocytes are novel sites of expression and regulation of adiponectin and resistin. FEBS Lett. 2002;532(3):345-50.
  • 4. Hosoya M, Kawamata Y, Fukusumi S, Fujii R, Habata Y, Hinuma S et al. Molecular and functional characteristics of APJ. Tissue distribution of mRNA and interaction with the endogenous ligand apelin. J Biol Chem. 2000;275 (28):21061-7.
  • 5. Wagenknecht LE, Langefeld CD, Scherzinger AL, Norris JM, Haffner SM, Saad MF et al. Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes. 2003;52(10):2490-6.
  • 6. Saijo Y, Kiyota N, Kawasaki Y, Miyazaki Y, Kashimura J, Fukuda M et al. Relationship between C-reactive protein and visceral adipose tissue in healthy Japanese subjects. Diabetes Obes Metab. 2004;6(4):249-58.
  • 7. Kanaya AM, Harris T, Goodpaster BH, Tylavsky F, Cummings SR. Health, Aging, and Body Composition (ABC) Study. Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults. Diabetes Care. 2004;27(6):1375-80.
  • 8. Azuma K, Katsukawa F, Oguchi S, Murata M, Yamazaki H, Shimada A et al. Correlation between serum resistin level and adiposity in obese individuals. Obes Res. 2003;11(8):997-1001.
  • 9. Miyazawa-Hoshimoto S, Takahashi K, Bujo H, Hashimoto N, Saito Y. Elevated serum vascular endothelial growth factor is associated with visceral fat accumulation in human obese subjects. Diabetologia. 2003;46 (11): 1483-8.
  • 10. Ohlson LO, Larsson B, Svärdsudd K, Welin L, Eriksson H, Wilhelmsen L, et al. The influence of body fat distribution on the incidence of diabetes mellitus. 13.5 years of follow-up of the participants in the study of men born in 1913. Diabetes. 1985;34(10):1055-8.
  • 11. Lapidus L, Bengtsson C, Larsson B, Pennert K, Rybo E, Sjöström L. Distribution of adipose tissue and risk of cardiovascular disease and death: a 12 year follow up of participants in the population study of women in Gothenburg, Sweden. Br Med J (Clin Res Ed). 1984;289(6454):1257- 61.
  • 12. Ducimetiere P, Richard J, Cambien F. The pattern of subcutaneous fat distribution in middle-aged men and the risk of coronary heart disease: the Paris Prospective Study. Int J Obes. 1986;10(3):229-40.
  • 13. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86(5): 1930-5.
  • 14. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM. The hormone resistin links obesity to diabetes. Nature. 2001;18;409(6818):307-12.
  • 15. Herrera E, Lasunción MA, Palacín M, Zorzano A, Bonet B. Intermediary metabolism in pregnancy. First theme of the Freinkel era. Diabetes. 1991;40 (Suppl 2):83-8.
  • 16. Knopp RH, Herrera E, Freinkel N. Carbohydrate metabolism in pregnancy. 8. Metabolism of adipose tissue isolated from fed and fasted pregnant rats during late gestation. J Clin Invest. 1970;49(7):1438-46.
  • 17. Mårin P, Andersson B, Ottosson M, Olbe L, Chowdhury B, Kvist H. The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism. 1992;41 (11): 1242-8.
  • 18. de Mutsert R, Gast K, Widya R, de Koning E, Jazet I, Lamb H. Associations of Abdominal Subcutaneous and Visceral Fat with Insulin Resistance and Secretion Differ Between Men and Women: The Netherlands Epidemiology of Obesity Study. Metab Syndr Relat Disord. 2018;16 (1):54-63.
  • 19. Köşüş N, Köşüş A, Turhan N. Relation between abdominal subcutaneous fat tissue thickness and inflammatory markers during pregnancy. Arch Med Sci. 2014;10(4): 739-45.
  • 20. Suresh A, Liu A, Poulton A, Quinton A, Amer Z, Mongelli M, et al. Comparison of maternal abdominal subcutaneous fat thickness and body mass index as markers for pregnancy outcomes: A stratified cohort study. Aust N Z J Obstet Gynaecol. 2012;52(5):420-6.
  • 21. Kennedy NJ, Peek MJ, Quinton AE, Lanzarone V, Martin A, Benzie R, et al. Maternal abdominal subcutaneous fat thickness as a predictor for adverse pregnancy outcome: a longitudinal cohort study. BJOG. 2016;123(2):225-32.
  • 22. Pianeta Nutrizione kids: international pediatric conference on food, physical activity, growth and well-being: Milan, Italy. 25-27 June 2015. Ital J Pediatr. 2016;42 (Suppl 1): 53. (No authors listed).
  • 23. Bruno R, Petrella E, Bertarini V, Neri I, Facchinetti F. Lifestyle-induced maternal body composition changes and birthweight in overweight/obese pregnant women. J Pediatr Neonat Individual Med. 2015;4(2):e040227.
APA demir bayraktutan a, Karlı P, ayan d (2020). The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. , 11 - 16. 10.21613/GORM.2019.970
Chicago demir bayraktutan aslihan dilara,Karlı Pervin,ayan durmuş The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. (2020): 11 - 16. 10.21613/GORM.2019.970
MLA demir bayraktutan aslihan dilara,Karlı Pervin,ayan durmuş The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. , 2020, ss.11 - 16. 10.21613/GORM.2019.970
AMA demir bayraktutan a,Karlı P,ayan d The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. . 2020; 11 - 16. 10.21613/GORM.2019.970
Vancouver demir bayraktutan a,Karlı P,ayan d The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. . 2020; 11 - 16. 10.21613/GORM.2019.970
IEEE demir bayraktutan a,Karlı P,ayan d "The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women." , ss.11 - 16, 2020. 10.21613/GORM.2019.970
ISNAD demir bayraktutan, aslihan dilara vd. "The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women". (2020), 11-16. https://doi.org/10.21613/GORM.2019.970
APA demir bayraktutan a, Karlı P, ayan d (2020). The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. GORM:Gynecology Obstetrics & Reproductive Medicine, 26(1), 11 - 16. 10.21613/GORM.2019.970
Chicago demir bayraktutan aslihan dilara,Karlı Pervin,ayan durmuş The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. GORM:Gynecology Obstetrics & Reproductive Medicine 26, no.1 (2020): 11 - 16. 10.21613/GORM.2019.970
MLA demir bayraktutan aslihan dilara,Karlı Pervin,ayan durmuş The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.26, no.1, 2020, ss.11 - 16. 10.21613/GORM.2019.970
AMA demir bayraktutan a,Karlı P,ayan d The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(1): 11 - 16. 10.21613/GORM.2019.970
Vancouver demir bayraktutan a,Karlı P,ayan d The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(1): 11 - 16. 10.21613/GORM.2019.970
IEEE demir bayraktutan a,Karlı P,ayan d "The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women." GORM:Gynecology Obstetrics & Reproductive Medicine, 26, ss.11 - 16, 2020. 10.21613/GORM.2019.970
ISNAD demir bayraktutan, aslihan dilara vd. "The Relationship Between Abdominal Subcutan Fat Tissue Thickness and HbA1c in Pregnant Women". GORM:Gynecology Obstetrics & Reproductive Medicine 26/1 (2020), 11-16. https://doi.org/10.21613/GORM.2019.970