Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?
Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 25 - 30 Metin Dili: İngilizce DOI: 10.21613/GORM.2018.897 İndeks Tarihi: 18-12-2020
Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?
Öz: OBJECTIVE: To compare clinical pregnancy rate through ICSI-ET between polycystic ovarian syndromepatients and women with normal ovaries (control group). We also investigated whether serum anti-Mullerian hormone level or LH/FSH ratio may predict clinical pregnancy rate in both groups.STUDY DESIGN: In this retrospective study, endocrine/clinical parameters and cycle characteristics ofwomen with polycystic ovarian syndrome (n=32) and women with normal ovaries (n=115) aged <40years were evaluated.RESULTS: Clinical pregnancy rate in polycystic ovarian syndrome group did not differ from that in thecontrol group (31.3% vs. 32.2%, p>0.05, respectively). The LH/FSH ratio was significantly higher inwomen who conceived compared to women who did not in the polycystic ovarian syndrome group (0.9vs. 0.6, respectively, p=0.4). The cut-off value of 0.6 in the LH/FSH ratio predicted clinical pregnancywith a specificity of 76% and a sensitivity of 65% in the polycystic ovarian syndrome group. Anti-Mullerian hormone was significantly higher in women who conceived compared to women who did notin the control group (4.0 ng/mL vs. 2.1 ng/mL, respectively, p=0.4).CONCLUSION: Polycystic ovarian syndrome patients have a similar clinical pregnancy rate with womenhaving normal ovaries through ICSI-ET. The LH/FSH ratio assessed prior to ovulation induction was significantlyhigher in pregnant polycystic ovarian syndrome patients compared to polycystic ovarian syndromepatients who did not conceive. Anti-Mullerian hormone level was significantly higher in pregnantwomen compared to non-pregnant women with normal ovaries.
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- 1. Dunaif A, Segal KR, Shelley DR, Green G, Dobrjansky A, Licholai T. Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes. 1992;41(10):1257-66.
- 2. Franks S. Polycystic ovary syndrome. N Engl J Med. 1995 28;333(13):853-61.
- 3. Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR, Azziz R. Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998;83(9):3078-82.
- 4. Rotterdam ESHRE/ASRM Sponsored PKOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004 Jan;81(1):19-25.
- 5. Wiweko B, Maidarti M, Priangga MD, Shafira N, Fernando D, Sumapraja K, et al. Anti-mullerian hormone as a diagnostic and prognostic tool for PCOS patients. J.Assist Reprod Genet. 2014; 31(10):1311-6.
- 6. Sahmay S, Guralp O, Aydogan B, Cepni I, Oral E, Irez T. Anti mullerian hormone and polycystic ovary syndrome: assessment of the clinical pregnancy rates in invitro fertilization patients. Gynecol Endocrinol. 2013; 29(5):440-3.
- 7. Ocal P, Sahmay S, Çetin M, Irez T, Guralp O, Cepni I. Serum anti mullerian hormone and antral follicle count as predictive markers of OHSS in ART cycles. J Assist Reprod Genet. 2011;28(12):1197-203.
- 8. Irez T, Ocal P, Guralp O, Cetin M, Aydogan B, Sahmay S. Different serum antimullerian hormone concentrations are associated with oocyte quality embryo development parameters and IVF-ICSI outcomes. Arch Gynecol Obstet. 2011;284(5):1295-301.
- 9. Zhang F, Liu XL, Rong N, Huang XW. Clinical value of serum anti-mullerian hormone and inhibin B in prediction of ovarian response in patients with polycystic ovary syndrome. J Huazhong Univ Sci Technolog Med Sci. 2017;37(1):70-3.
- 10. van Rooij IA, Broekmans FJ, Hunault CC, Scheffer GJ, Eijkemans MJ, de Jong FH et al. Use of ovarian reserve tests for the prediction of ongoing pregnancy in couples with unexplained or mild male infertility. Reprod Biomed Online. 2006;12(2):182-90.
- 11. Chin KV, Seifer DB, Feng B, Lin Y, Shin WC. DNA microarray analysis of the expression profiles of luteinized granulosa cells as a function of ovarian reserve. Fertil Steril. 2002;77(6):1214-8.
- 12. Hamdine O, Eijkemans MJ, Lentjes EW, Torrance HL, Macklon NS, Fauser BC, et al. Ovarian response prediction in GnRH antagonist treatment for IVF using anti- Mullerian hormone. Hum Reprod. 2015;30(1):170-8.
- 13 Nikolaou D, Gilling-Smith C. Early ovarian ageing: Are women with polycystic ovaries protected? Hum Reprod. 2004;19(10):2175-9.
- 14. Engmann L, Maconochie N, Sladkevicius P, Bekir J, Campbell S, Tan SL. The outcome of in-vitro fertilization treatment in women with sonographic evidence of polycystic ovarian morphology. Hum Reprod. 1999;14(1):167- 71.
- 15. Zebitay AG, Cetin O, Verit FF, Keskin S, Sakar MN, Karahuseyinoglu S, et al. The role of ovarian reserve markers in prediction of clinical pregnancy. J Obstet Gynaecol. 2017;37(4):492-7.
- 16. Tal R, Seifer DB, Khanimov M, Malter HE, Grazi RV, Leader B. Characterization of women with elevated antimüllerian hormone levels (AMH): correlation of AMH with polycystic ovarian syndrome phenotypes and assisted reproductive technology outcomes. Am J Obstet Gynecol. 2014;211(1):59.e1-8.
- 17. Stracquadanio M, Ciotta L, Palumbo MA. Relationship between serum anti-Mullerian hormone and intrafollicular AMH levels in PCOS women. Gynecol Endocrinol. 2018;34(3):223-8.
- 18. Melado-Vidales L, Fernández-Nistal A, Martínez Fernández V, Verdú Merino V, Bruna Catalán I, Bajo Arenas JM. Anti-Mullerian hormone levels to predict oocyte maturity and embryo quality during controlled ovarian hyperstimulation. Minerva Ginecol. 2017;69 (3):225-32.
- 19. Ebner T, Sommergruber M, Moser M, Shebl O, Schreier- Lechner E, Tews G. Basal level of anti-Mullerian hormone is associated with oocyte quality in stimulated cycles. Hum Reprod. 2006;21(3):2022-6.
- 20. Skałba P, Cygal A, Madej P, Dąbkowska-Huć A, Sikora J, Martirosian G, et al. Is the plasma anti-Mullerian hormone (AMH) level associated with body weight and metabolic, and hormonal disturbances in women with and without polycystic ovary syndrome? Eur J Obstet Gynecol Reprod Biol. 2011;158(2):254-9.
- 21. Qiao J, Feng HL. Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence. Hum Reprod Update. 2011;17(1):17-33.
- 22. Fanchin R, Mendez Lozano DH, Frydman N, Gougeon A, di Clemente N, Frydman R, et al. Anti-Mullerian hormone concentrations in the follicular fluid of the preovulatory follicle are predictive of the implantation potential of the ensuing embryo obtained by in vitro fertilization. J Clin Endocrinol Metab. 2007;92(5):1796-802.
- 23. Yilmaz T, Tavukcuoglu S, Tasdemir S, Esenkaya S, Irez T. Can follicular fluid anti-Mullerian hormone level be a determinant for pregnancy in women under 35 years of age? Int J Womens Health. 2018;6(1):6-10.
- 24. Franks S. Polycystic ovary syndrome: a changing perspective. Clin Endocrinol (Oxf). 1989;31(1):87-120.
- 25. Jayasena CN, Franks S. The management of patients with polycystic ovary syndrome. Nat Rev Endocrinol. 2014;10 (10):624-36.
- 26. Katsikis I, Karkanaki A, Misichronis G, Delkos D, Kandaraki EA, Panidis D. Phenotypic expression, body mass index and insulin resistance in relation to LH levels in women with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol. 2011;156(2):181-5.
- 27. Wiser A, Shehata F, Holzer H, Hyman JH, Shalom-Paz E, Son WY, et al. Effect of high LH/FSH ratio on women with polycystic ovary syndrome undergoing in vitro maturation treatment. J Reprod Med. 2013;58(5-6):219-23.
- 28. Zhang F, Liu XL, Rong N, Huang XW. Clinical value of serum anti-mullerian hormone and inhibin B in prediction of ovarian response in patients with polycystic ovary syndrome. J Huazhong Univ Sci Technolog Med Sci. 2017; 37(1):70-3.
| APA | ELGÜN T, Karacan M, Sandal A, IREZ T (2020). Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. , 25 - 30. 10.21613/GORM.2018.897 |
| Chicago | ELGÜN TUĞBA,Karacan Meric,Sandal Asiye İzem,IREZ TULAY Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. (2020): 25 - 30. 10.21613/GORM.2018.897 |
| MLA | ELGÜN TUĞBA,Karacan Meric,Sandal Asiye İzem,IREZ TULAY Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. , 2020, ss.25 - 30. 10.21613/GORM.2018.897 |
| AMA | ELGÜN T,Karacan M,Sandal A,IREZ T Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. . 2020; 25 - 30. 10.21613/GORM.2018.897 |
| Vancouver | ELGÜN T,Karacan M,Sandal A,IREZ T Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. . 2020; 25 - 30. 10.21613/GORM.2018.897 |
| IEEE | ELGÜN T,Karacan M,Sandal A,IREZ T "Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?." , ss.25 - 30, 2020. 10.21613/GORM.2018.897 |
| ISNAD | ELGÜN, TUĞBA vd. "Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?". (2020), 25-30. https://doi.org/10.21613/GORM.2018.897 |
| APA | ELGÜN T, Karacan M, Sandal A, IREZ T (2020). Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. GORM:Gynecology Obstetrics & Reproductive Medicine, 26(1), 25 - 30. 10.21613/GORM.2018.897 |
| Chicago | ELGÜN TUĞBA,Karacan Meric,Sandal Asiye İzem,IREZ TULAY Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. GORM:Gynecology Obstetrics & Reproductive Medicine 26, no.1 (2020): 25 - 30. 10.21613/GORM.2018.897 |
| MLA | ELGÜN TUĞBA,Karacan Meric,Sandal Asiye İzem,IREZ TULAY Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.26, no.1, 2020, ss.25 - 30. 10.21613/GORM.2018.897 |
| AMA | ELGÜN T,Karacan M,Sandal A,IREZ T Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(1): 25 - 30. 10.21613/GORM.2018.897 |
| Vancouver | ELGÜN T,Karacan M,Sandal A,IREZ T Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(1): 25 - 30. 10.21613/GORM.2018.897 |
| IEEE | ELGÜN T,Karacan M,Sandal A,IREZ T "Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?." GORM:Gynecology Obstetrics & Reproductive Medicine, 26, ss.25 - 30, 2020. 10.21613/GORM.2018.897 |
| ISNAD | ELGÜN, TUĞBA vd. "Can Serum Anti-Mullerian Hormone Level and LH / FSH Ratio Be Predictive of Clinical Pregnancy Through Intracytoplasmic Sperm Injection - Embryo Transfer?". GORM:Gynecology Obstetrics & Reproductive Medicine 26/1 (2020), 25-30. https://doi.org/10.21613/GORM.2018.897 |
