Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience

önal, özgür; Batioglu, Ali Sertac; Kanat-Pektas, Mine; GÜRLEK, BERIL; Yılmaz, Nafiye; kale, ibrahim

doi:10.21613/GORM.2019.978

Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience

Beril GÜRLEK, (Recep Tayyip Erdoğan Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Rize, Türkiye)

Ali Sertaç BATIOĞLU, (Uşak Üniversitesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Uşak, Türkiye)

Mine PEKTAŞ, (Afyon Kocatepe Üniversitesi, Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Afyonkarahisar, Türkiye)

İbrahim KALE, (Ümraniye Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, İstanbul, Türkiye)

Özgür ÖNAL, (Süleyman Demirel Üniversitesi, Halk Sağlığı Bölümü, Isparta, Türkiye)

Nazife YILMAZ (Zekai Tahir Burak Kadın Sağlık ve Araştırma Hastanesi, Üreme Endokrinolojisi Anabilim Dalı, Ankara, Türkiye)

GORM:Gynecology Obstetrics & Reproductive Medicine

1 0

Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 31 - 37 Metin Dili: İngilizce DOI: 10.21613/GORM.2019.978 İndeks Tarihi: 18-12-2020

Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience

Öz:

OBJECTIVE: This aim of this study is to assess the ovulation induction cycles based on clomiphene citrateand gonadotropin administration and specify the factors associated with successful outcomes.STUDY DESIGN: This is a prospective study of 631 patients who underwent 917 ovulation induction cycles.While clomiphene citrate was used in 680 cycles (74.2%) and recombinant follicle-stimulating hormonewas administered in 237 cycles (25.8%).RESULTS: A total of 153 pregnancies were achieved in 917 ovulation induction cycles, indicating a clinicalpregnancy rate of 16.7%. The ovulation induction cycles which ended up with clinical pregnancy hada significantly lower frequency of smoking (p=0.005), shorter infertility duration (p=0.001), higher basalluteinizing hormone (p=0.021) and lower basal progesterone (p=0.008) than unsuccessful cycles. Theclomiphene citrate cycles which ended up with clinical pregnancy had a significantly lower frequency ofsmoking (p=0.011), shorter infertility duration (p=0.001) and lower basal progesterone (p=0.013) thanthe unsuccessful cycles. The recombinant follicle-stimulating hormone cycles which ended up with clinicalpregnancy had a significantly higher basal luteinizing hormone (p=0.008) than the unsuccessful cycles.Basal luteinizing hormone and progesterone concentrations could significantly distinguish the patientswho were able to conceive in ovulation induction cycles (p=0.021 and p=0.008, respectively).CONCLUSIONS: Smoking, longer duration of infertility, and elevated basal progesterone are poor prognosticfactors for clinical pregnancy in clomiphene citrate and recombinant follicle-stimulating hormonecycles.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	GÜRLEK B, Batioglu A, Kanat-Pektas M, kale i, önal ö, Yılmaz N (2020). Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. , 31 - 37. 10.21613/GORM.2019.978
Chicago	GÜRLEK BERIL,Batioglu Ali Sertac,Kanat-Pektas Mine,kale ibrahim,önal özgür,Yılmaz Nafiye Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. (2020): 31 - 37. 10.21613/GORM.2019.978
MLA	GÜRLEK BERIL,Batioglu Ali Sertac,Kanat-Pektas Mine,kale ibrahim,önal özgür,Yılmaz Nafiye Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. , 2020, ss.31 - 37. 10.21613/GORM.2019.978
AMA	GÜRLEK B,Batioglu A,Kanat-Pektas M,kale i,önal ö,Yılmaz N Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. . 2020; 31 - 37. 10.21613/GORM.2019.978
Vancouver	GÜRLEK B,Batioglu A,Kanat-Pektas M,kale i,önal ö,Yılmaz N Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. . 2020; 31 - 37. 10.21613/GORM.2019.978
IEEE	GÜRLEK B,Batioglu A,Kanat-Pektas M,kale i,önal ö,Yılmaz N "Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience." , ss.31 - 37, 2020. 10.21613/GORM.2019.978
ISNAD	GÜRLEK, BERIL vd. "Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience". (2020), 31-37. https://doi.org/10.21613/GORM.2019.978

APA	GÜRLEK B, Batioglu A, Kanat-Pektas M, kale i, önal ö, Yılmaz N (2020). Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. GORM:Gynecology Obstetrics & Reproductive Medicine, 26(1), 31 - 37. 10.21613/GORM.2019.978
Chicago	GÜRLEK BERIL,Batioglu Ali Sertac,Kanat-Pektas Mine,kale ibrahim,önal özgür,Yılmaz Nafiye Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. GORM:Gynecology Obstetrics & Reproductive Medicine 26, no.1 (2020): 31 - 37. 10.21613/GORM.2019.978
MLA	GÜRLEK BERIL,Batioglu Ali Sertac,Kanat-Pektas Mine,kale ibrahim,önal özgür,Yılmaz Nafiye Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. GORM:Gynecology Obstetrics & Reproductive Medicine, vol.26, no.1, 2020, ss.31 - 37. 10.21613/GORM.2019.978
AMA	GÜRLEK B,Batioglu A,Kanat-Pektas M,kale i,önal ö,Yılmaz N Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(1): 31 - 37. 10.21613/GORM.2019.978
Vancouver	GÜRLEK B,Batioglu A,Kanat-Pektas M,kale i,önal ö,Yılmaz N Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience. GORM:Gynecology Obstetrics & Reproductive Medicine. 2020; 26(1): 31 - 37. 10.21613/GORM.2019.978
IEEE	GÜRLEK B,Batioglu A,Kanat-Pektas M,kale i,önal ö,Yılmaz N "Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience." GORM:Gynecology Obstetrics & Reproductive Medicine, 26, ss.31 - 37, 2020. 10.21613/GORM.2019.978
ISNAD	GÜRLEK, BERIL vd. "Success Rates of Clomiphene Citrate and Recombinant Gonadotropin Cycles: A Single-Center Experience". GORM:Gynecology Obstetrics & Reproductive Medicine 26/1 (2020), 31-37. https://doi.org/10.21613/GORM.2019.978