Songül Ece GÖNEN
(İstanbul Sağlık Bilimleri Üniversitesi, Kanuni Sultan Süleyman Araştırması ve Eğitim Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye)
Pınar KADİROĞULLARI
(İstanbul Sağlık Bilimleri Üniversitesi, Kanuni Sultan Süleyman Araştırması ve Eğitim Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye)
Kerem SEÇKİN
(İstanbul Sağlık Bilimleri Üniversitesi, Kanuni Sultan Süleyman Araştırması ve Eğitim Hastanesi, Kadın Hastalıkları ve Doğum Kliniği, İstanbul, Türkiye)
Bünyamin BÖREKÇİ
(Erzurum Atatürk Üniversitesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Erzurum, Türkiye)
Yıl: 2020Cilt: 26Sayı: 1ISSN: 1300-4751 / 2602-4918Sayfa Aralığı: 38 - 43İngilizce

21 0
Does Acupuncture Have Any Benefit in the IVF Treatment of Couples with Unexplained Infertility; A Prospective Randomized Controlled Trial
OBJECTIVE: We aimed to investigate the effect of acupuncture performed as an adjuvant therapy to in vitro fertilization, on pregnancy rates by performing acupuncture on the day of embryo transfer, one hour before the procedure and one hour after the procedure. STUDY DESIGN: In this open-label randomized prospective controlled study, 60 unexplained infertility patients enrolled for in vitro fertilization treatment were randomized by a computer-based number generator for acupuncture performance and no-treatment. All patients received rFSH (Gonal-F®) for ovulation induction and the antagonist Cetrorelix (Cetrotide®) to prevent premature ovulation. Ovulation was triggered by using hCG (Ovitrelle®) and egg collection was done after 36-48 hours. In the study group, acupuncture was performed by intradermal needling, bilaterally with a sterile needle, both one hour before and one hour after the embryo transfer. Acupuncture was not performed on the control group. The results of the treatment were evaluated 12 days after embryo transfer. RESULTS: Thirty patients were randomized into the study group and 30 patients were randomly placed in the control group. Although there was no statistically significant difference between groups in terms of β-hCG positivity, it was 43.3% in the study group and 36.7% in the control group (p>0.05). CONCLUSION: The success rate of in vitro fertilization was higher in terms of pregnancy rate in the patient group who received acupuncture procedure as well, but the difference was not statistically significant. This may be due to the type of acupuncture procedure selected or insufficient sample size. As a result, further studies involving larger numbers of participants and using different acupuncture techniques are needed.
DergiAraştırma MakalesiErişime Açık
  • 1. Cramer DW, Walker AM, Schiff I. Statistical methods in evaluating the outcome of infertility therapy. Fertil Steril. 1979;32(1):80-6.
  • 2. Qian Y, Xia XR, Ochin H, Huang C, Gao C, Gao L, et al. Therapeutic effect of acupuncture on the outcomes of in vitro fertilization: a systematic review and meta-analysis. Arch Gynecol Obstet. 2017;295(3):543-58.
  • 3. Qu F, Zhou J, Ren RX. Effects of acupuncture on the outcomes of in vitro fertilization: a systematic review and meta-analysis. J Altern Complement Med. 2012;18(5): 429-39.
  • 4. El-Toukhy T, Khalaf Y. A new study of acupuncture in IVF: pointing in the right direction. Reprod Biomed Online. 2010;21(3):278-9.
  • 5. Hunt KJ, Coelho HF, Wider B, Perry R, Hung SK, Terry R, et al. Complementary and alternative medicine use in England: results from a national survey. Int J Clin Pract. 2010;64(11):1496-502.
  • 6. Dundee JW, Ghaly RG, Fitzpatrick KT, Abram WP, Lynch GA. Acupuncture prophylaxis of cancer chemotherapy-induced sickness. J R Soc Med. 1989;82(5):268-71.
  • 7. Christensen PA, Noreng M, Andersen PE, Nielsen JW. Electroacupuncture and postoperative pain. Br J Anaesth. 1989;62(3):258-62.
  • 8. He D, Berg JE, Hostmark AT. Effects of acupuncture on smoking cessation or reduction for motivated smokers. Prev Med. 1997;26(2):208-14.
  • 9. Shlay JC, Chaloner K, Max MB, Flaws B, Reichelderfer P, Wentworth D, et al. Acupuncture and amitriptyline for pain due to HIV-related peripheral neuropathy: a randomized controlled trial. Terry Beirn Community Programs for Clinical Research on AIDS. JAMA. 1998;280(18):1590-5.
  • 10. Eisenberg DM, Davis RB, Ettner SL, Appel S, Wilkey S, Van Rompay M, et al. Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. JAMA. 1998;280(18):156975.
  • 11. Harris P, Rees R. The prevalence of complementary and alternative medicine use among the general population: a systematic review of the literature. Complement Ther Med 2000;8(2):88-96.
  • 12. Stener-Victorin E, Kobayashi R, Kurosawa M. Ovarian blood flow responses to electro-acupuncture stimulation at different frequencies and intensities in anaesthetized rats. Auton Neurosci. 2003;108(1-2):50-6.
  • 13. Stener-Victorin E, Kobayashi R, Watanabe O, Lundeberg T, Kurosawa M. Effect of electro-acupuncture stimulation of different frequencies and intensities on ovarian blood flow in anaesthetized rats with steroid-induced polycystic ovaries. Reprod Biol Endocrinol. 2004;2;16.
  • 14. Stener-Victorin E, Waldenström U, Wikland M, Nilsson L, Hägglund L, Lundeberg T. Electro-acupuncture as a peroperative analgesic method and its effects on implantation rate and neuropeptide Y concentrations in follicular fluid. Hum Reprod. 2003;18(7):1454-60.
  • 15. Humaidan P, Stener-Victorin E. Pain relief during oocyte retrieval with a new short duration electro-acupuncture technique - an alternative to conventional analgesic methods. Hum Reprod. 2004;19(6):1367-72.
  • 16. Craig LB, Rubin LE, Peck JD, Anderson M, Marshall LA, Soules MR. Acupuncture performed before and after embryo transfer a randomized controlled trial. J Reprod Med. 2014;59(5-6):313-20.
  • 17. Paulus WE, Zhang M, Strehler E, El-Danasouri I, Sterzik K. Influence of acupuncture on the pregnancy rate in patients who undergo assisted reproduction therapy. Fertil Steril. 2002;77(4):721-4.
  • 18. Shen C, Wu M, Shu D, Zhao X, Gao Y. The role of acupuncture in in vitro fertilization: a systematic review and meta-analysis. Gynecol Obstet Invest. 2015;79(1): 1-12.
  • 19. Cheong YC, Dix S, Hung Yu Ng E, Ledger WL, Farquhar C. Acupuncture and assisted reproductive technology. Cochrane Database Syst Rev. 2013;7:CD006920.
  • 20. Manheimer E, van der Windt D, Cheng K, Stafford K, Liu J, Tierney J, et al. The effects of acupuncture on rates of clinical pregnancy among women undergoing in vitro fertilization: a systematic review and meta-analysis. Hum Reprod Update. 2013;19(6):696-713.
  • 21. Zhang M, Huang G, Lu F, El-Danasouri I, Sterzik K: Effect of acupuncture on rate of pregnancy among women undergoing embryo transfer: a prospective randomized placebo controlled trial. Zhongguo Zhen Jiu. 2003;23:3-5.
  • 22. Westergaard LG, Mao Q, Krogslund M, Sandrini S, Lenz S, Grinsted J. Acupuncture on the day of embryo transfer significantly improves the reproductive outcome in infertile women: a prospective, randomized trial. Fertil Steril. 2006;85(5):1341-6.
  • 23. Dieterle S, Ying G, Hatzmann W, Neuer A. Effect of acupuncture on the outcome of in vitro fertilization and intracytoplasmic sperm injection: a randomized, prospective, controlled clinical study. Fertil Steril. 2006;85(5): 1347-51.
  • 24. Smith C, Coyle PM, Norman RJ. Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer. Fertil Steril. 2006; 85(5):1352-8.

TÜBİTAK ULAKBİM Ulusal Akademik Ağ ve Bilgi Merkezi Cahit Arf Bilgi Merkezi © 2019 Tüm Hakları Saklıdır.