The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman

bolu, semih; TURGUT, MEHMET; İŞLEYEN, FATİH

The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman

Semih Bolu, (Adıyaman Üniversitesi, Tıp Fakültesi, Çocuk Endokrinoloji Anabilim Dalı, Adıyaman, Türkiye)

Fatih İşleyen, (Şanlıurfa Balıklıgöl Devlet Hastanesi, Çocuk Sağlığı ve Hastalıkları, Şanlıurfa, Türkiye)

Mehmet TURGUT (Adıyaman Üniversitesi, Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı, Adıyaman, Türkiye)

Ege Tıp Dergisi

3 0

Yıl: 2020 Cilt: 59 Sayı: 2 Sayfa Aralığı: 83 - 90 Metin Dili: İngilizce İndeks Tarihi: 19-12-2020

The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman

Öz:

Aim: The most common cause of goiter in developed countries is autoimmune diseases, while themost common cause in developing countries is iodine deficiency. We aimed to evaluate the clinicaland laboratory results and etiological and demographic characteristics of cases presenting with goiter.Materials and Methods: Seventy-five patients aged between 5 and 17 years presenting with goiterbetween October 2016 and January 2019 were included in the study.Results: 90.7% (68) of children with goiter were female and 9.3% (7) male, the rate of goiter being9.7-fold higher among girls. In terms of etiology, 43 patients (57.3%) were diagnosed with iodinedeficiency, 25 (33.3%) with Hashimoto’s thyroiditis (HT), five with Graves’ disease (6.7%), and two(2.7%) with thyroid hormone resistance (THR). Mean ages were 13.7±2.1 years in the iodine deficientcases, 13.7±2.7 in the HT group, 14.3±1.4 in the Graves’ disease patients, and 8.2±2.3 in the patientswith THR. The highest mean urinary iodine level among iodine deficient patients was 45±27.1 (12.10-84.13) μg/L in Adıyaman center, while the lowest value was determined in Gerger district at 16.8±3.1(14.27-20.25) μg/L, and 11 patients were diagnosed with mild iodine deficiency, 20 with moderatedeficiency, and 12 with severe deficiency.Conclusion: Iodine deficiency was the most common cause of goiter in children in the province ofAdıyaman, followed by autoimmune thyroid gland diseases such as Graves’ disease and HT. Thisstudy shows that iodine deficiency remains still as a problem in our province.

Anahtar Kelime:

Adıyaman ilinde guatrla başvuran çocuk hastalarda etiyolojik dağılım ile klinik ve laboratuvar özellikler

Öz:

Amaç: Gelişmiş ülkelerde guatrın en sık sebebi otoimmün hastalıklar iken gelişmekte olan ülkelerde en yaygın neden iyot eksikliğidir. Guatr ile başvuran olguların klinik ve laboratuvar sonuçları ile etiyolojik ve demografik özelliklerini değerlendirmeyi amaçladık. Gereç ve Yöntem: Çalışmaya Ekim 2016 ile Ocak 2019 tarihleri arasında guatr ile başvuran 5-17 yaş arasındaki 75 hasta dahil edildi. Bulgular: Guatrlı çocukların % 90,7'si (68) kız, % 9,3'ü (7) erkek idi ve guatr oranı kızlarda 9,7 kat daha yüksek bulundu. Etiyoloji açısından 43 hastaya (% 57,3) iyot eksikliği, 25 hastaya (% 33,3) Hashimoto tiroiditi (HT), 5 hastaya Graves hastalığı (% 6,7) ve 2 hastaya (% 2,7) Tiroid hormon direnci (THD) tanısı konuldu. İyot eksikliği olan olgularda ortalama yaş 13,7 ± 2,1 yıl, HT grubunda 13,7 ± 2,7 yıl, Graves hastalarında 14,3 ± 1,4 yıl ve THD'li hastalarda 8,2 ± 2,3 yıl idi. İyot eksikliği olan hastalarda ortalama idrar iyot düzeyi en yüksek Adıyaman merkezde 45 ± 27,1 (12,10-84,13) μg/L olarak saptanırken, en düşük değer Gerger bölgesinde 16,8 ± 3,1 (14,27-20,25) μg/L idi. Sonuç: İyot eksikliği Adıyaman ilindeki çocuklarda guatrın en sık sebebi olup bunu Graves hastalığı ve HT gibi otoimmün tiroid bezi hastalıkları izliyordu. Bu çalışma iyot eksikliğinin ilimiz genelinde yaygın bir sorun olarak devam ettiğini göstermektedir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	bolu s, İŞLEYEN F, TURGUT M (2020). The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. , 83 - 90.
Chicago	bolu semih,İŞLEYEN FATİH,TURGUT MEHMET The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. (2020): 83 - 90.
MLA	bolu semih,İŞLEYEN FATİH,TURGUT MEHMET The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. , 2020, ss.83 - 90.
AMA	bolu s,İŞLEYEN F,TURGUT M The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. . 2020; 83 - 90.
Vancouver	bolu s,İŞLEYEN F,TURGUT M The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. . 2020; 83 - 90.
IEEE	bolu s,İŞLEYEN F,TURGUT M "The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman." , ss.83 - 90, 2020.
ISNAD	bolu, semih vd. "The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman". (2020), 83-90.

APA	bolu s, İŞLEYEN F, TURGUT M (2020). The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. Ege Tıp Dergisi, 59(2), 83 - 90.
Chicago	bolu semih,İŞLEYEN FATİH,TURGUT MEHMET The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. Ege Tıp Dergisi 59, no.2 (2020): 83 - 90.
MLA	bolu semih,İŞLEYEN FATİH,TURGUT MEHMET The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. Ege Tıp Dergisi, vol.59, no.2, 2020, ss.83 - 90.
AMA	bolu s,İŞLEYEN F,TURGUT M The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. Ege Tıp Dergisi. 2020; 59(2): 83 - 90.
Vancouver	bolu s,İŞLEYEN F,TURGUT M The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman. Ege Tıp Dergisi. 2020; 59(2): 83 - 90.
IEEE	bolu s,İŞLEYEN F,TURGUT M "The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman." Ege Tıp Dergisi, 59, ss.83 - 90, 2020.
ISNAD	bolu, semih vd. "The etiological distribution and clinical and laboratory characteristics of pediatric patients presenting with goiter in the province of Adıyaman". Ege Tıp Dergisi 59/2 (2020), 83-90.