Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Nebih LOLAK, (Adıyaman Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Adıyaman, Türkiye)
Süleyman AKOCAK (Adıyaman Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, Adıyaman, Türkiye)
Cumhuriyet Science Journal
2 0
Yıl: 2020 Cilt: 41 Sayı: 2 Sayfa Aralığı: 413 - 418 Metin Dili: İngilizce DOI: 10.17776/csj.595463 İndeks Tarihi: 19-12-2020

Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors

Öz:
Aromatic/heterocyclic Schiff bases are one of the most investigated and studied scaffold formany pharmaceutical applications. For this reason, in the current work, a series of aromaticbis-sulfonamide Schiff bases (7-15) were re-synthesized by reacting aromatic bis-aldehydesand aromatic sulfonamides in ethanol and assayed for antioxidant properties by using differentbioanalytical methods such as DPPH free radical scavenging assay, ABTS cation radicaldecolarization, cupric reducing antioxidant capacity (CUPRAC) and metal chelating methods.The acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition profiles werealso assessed. In general, the synthesized compounds showed weak antioxidant activity againstall tested methods, but two compounds (12 and 15) showed good CUPRAC activity at 10, 25and 50 μM concentrations. The weak inhibition potency was obtained against AChE andmoderate activity was observed against BChE enzymes at 200 μM.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Lolak N, akocak s (2020). Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. , 413 - 418. 10.17776/csj.595463
Chicago Lolak Nabih,akocak suleyman Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. (2020): 413 - 418. 10.17776/csj.595463
MLA Lolak Nabih,akocak suleyman Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. , 2020, ss.413 - 418. 10.17776/csj.595463
AMA Lolak N,akocak s Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. . 2020; 413 - 418. 10.17776/csj.595463
Vancouver Lolak N,akocak s Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. . 2020; 413 - 418. 10.17776/csj.595463
IEEE Lolak N,akocak s "Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors." , ss.413 - 418, 2020. 10.17776/csj.595463
ISNAD Lolak, Nabih - akocak, suleyman. "Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors". (2020), 413-418. https://doi.org/10.17776/csj.595463
APA Lolak N, akocak s (2020). Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. Cumhuriyet Science Journal, 41(2), 413 - 418. 10.17776/csj.595463
Chicago Lolak Nabih,akocak suleyman Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. Cumhuriyet Science Journal 41, no.2 (2020): 413 - 418. 10.17776/csj.595463
MLA Lolak Nabih,akocak suleyman Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. Cumhuriyet Science Journal, vol.41, no.2, 2020, ss.413 - 418. 10.17776/csj.595463
AMA Lolak N,akocak s Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. Cumhuriyet Science Journal. 2020; 41(2): 413 - 418. 10.17776/csj.595463
Vancouver Lolak N,akocak s Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors. Cumhuriyet Science Journal. 2020; 41(2): 413 - 418. 10.17776/csj.595463
IEEE Lolak N,akocak s "Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors." Cumhuriyet Science Journal, 41, ss.413 - 418, 2020. 10.17776/csj.595463
ISNAD Lolak, Nabih - akocak, suleyman. "Biological evaluation of aromatic bis-sulfonamide Schiff bases as antioxidant, acetylcholinesterase and butyrylcholinesterase inhibitors". Cumhuriyet Science Journal 41/2 (2020), 413-418. https://doi.org/10.17776/csj.595463
Sayfa Oluşturulma Tarihi
17-04-2024 17:52

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