Aim: To evaluate the quality of life of diabetic foot patients and affecting factors. Materials and Methods: The data of the study were collected from 171 patients who applied to the diabetic foot council of a university hospital between January - March 2020. For the collection of the data, the individual identification form, and the Diabetic Foot Scale - Short Form were used. In this scale, the sub-dimensions’ and scale total scores are range from 0 to 100, and the high mean score indicates a high quality of life, the low mean of score indicates a low quality of life. Research data were analyzed with IBM SPSS 25.0 software package. Results: Of the patients, 67.3% were male, 84.8% were married, and the mean age was 61.57 ± 10.03 years. The quality of life scores of women (p = 0.009), those receiving insulin therapy (p = 0.004), non-smokers (p = 0.027), those who do not consume alcohol (p = 0.030), and individuals who do not have any concomitant chronic disease (p = 0.003) was found to be at a high level. In regression estimation, it was found that receiving insulin therapy (β = -0.23, p = 0.024) and not having any concomitant chronic disease (β = -0.17, p = 0.037) positively affected the quality of life. Conclusion: As a result, it was observed that the quality of life of diabetic foot patients was at a moderate level, and there was a difference between the groups in terms of gender, type of treatment, smoking, alcohol consumption and accompanying chronic disease. It was determined that the type of treatment and accompanying chronic disease have a significant effect on the quality of life in diabetic foot patients.