Objectives: In the last three decades, Glutathione STransferaseP1 (GSTP1) 105IIe>Val had been extensively reported inthe case of Bladder cancer (BC). However, conflicting results were observedamong the studies. We aimed to perform a meta-analysis in effortto assess the association between GSTP1 105IIe>Val gene polymorphismand the risk of BC. Material and Methods: A meta-analysis wasconducted between May and July 2019. Papers were searched inPubmed, Embase, Cochrane, and Web of Science and information of interestwas extracted. The correlation and effect estimation were analyzedusing random or fixed effect model. Results: We collected 17 studiesconsisting of 4.236 cases and 5.085 controls. Our pooled calculation revealedthat GSTP1 105IIe>Val gene polymorphism was not associatedwith the risk of BC (OR 95%CI=1.11 [0.97-1.26], p=0.1190). We alsoperformed sub-group analyses in accordance with ethnicity and genotypingmethod. In ethnicity sub-group, we failed to clarify the correlationbetween GSTP1 105IIe>Val gene polymorphism and the risk of BCboth in Asian and Caucasian sub-groups. While, in genotyping methodsub-groups, either using polymerase chain reaction (PCR) or PCR-Restrictionfragment length polymorphism (PCR-RFLP) had no significantassociation with the risk of BC. Conclusion: There is no association betweenGSTP1 105IIe>Val gene polymorphism and the risk of BC.