With the rapid development of technology, the digitalization of all working structures and processes of institutions has become inevitable. In order to ensure digitalization in institutions, it is necessary to keep pace with change and transformation. Supply chains should be evaluated and reconstructed when necessary, taking into account constantly changing factors such as the performance of the current structure, possible risks, market shares, and competition conditions. Members in the supply chain must exchange information simultaneously and accurately. Otherwise, some problems such as idle capacity, transportation costs, excess stock, and customer dissatisfaction are encountered. In order to avoid such problems, real-time monitoring and effective management of processes in the supply chain are made possible by the industry 4.0-based sustainable supply chain. With the Industry 4.0 approach, the process is accelerated without supply chain management being complicated. The whole process is negatively affected if the needs of digitalization are not determined correctly or if we do not work with the right solution partners. A structure in which both strategic and operational needs and practices are discussed in a comprehensive manner, in which all aspects of the Industry 4.0 approach are addressed are required. For this purpose, analytic network process method was used to evaluate the difficulties in transition to industry 4.0 technology in sustainable supply chain management. The analytic network process is a method that takes into account the relationships and bonds between the factors and provides feedback. With this method, in order to ensure supply chain sustainability, the difficulties encountered in digitalization were analyzed and criteria weights were determined.