Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience

Yılmaz, Nurdan; demir, osman

doi:10.4274/tod.galenos.2019.30633

Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience

Nurdan YILMAZ, (Tokat Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Tokat, Türkiye)

Osman DEMİR (Tokat Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Tokat, Türkiye)

Türk Osteoporoz Dergisi

1 0

Yıl: 2020 Cilt: 26 Sayı: 2 Sayfa Aralığı: 58 - 62 Metin Dili: İngilizce DOI: 10.4274/tod.galenos.2019.30633 İndeks Tarihi: 25-11-2020

Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience

Öz:

Objective: This study aimed to evaluate the demographic, clinical and serological characteristics of patients with Sjögren’s syndrome (SS).Materials and Methods: Forty-nine patients with SS admitted to our outpatient clinic between January 2015 and April 2019 were included in this study. Patients were evaluated retrospectively in terms of age, gender and primary/secondary SS state; concomitant diseases with secondary SS, the presence of other related chronic diseases, minor salivary gland biopsy and autoantibody evaluation results were recorded.Results: The mean age of the 49 patients (46 females, 3 males) included in the study was 48.39±11.45 years (minimum: 18, maximum: 81). Female/male ratio was 15.3/1. Thirty-four (69.4%) of the patients had primary SS, while 15 (30.6%) patients were diagnosed as secondary SS. The most common symptom at the time of diagnosis was dry eye (98%) and dry mouth (92%). Antinuclear antibody positivity was found to be 40.8% and rheumatoid factor positivity as 28.6%. Anti-SS-A and anti-SS-B was positive in 46.9% and 26.5% of the patients, respectively.Conclusion: SS is characterised by heterogeneity of clinical manifestations, serological markers and symptoms. The symptom severity and variety of the patients are also affected by the other concomitant rheumatic diseases.

Anahtar Kelime:

Sjögren Sendromlu Hastaların Demografik, Klinik ve Serolojik Özellikleri: Üçüncü Basamak Deneyimi

Öz:

Amaç: Bu çalışmada kliniğimize başvuran Sjögren sendromu (SS) tanılı hastalarımızın demografik, klinik ve serolojik özelliklerin değerlendirmesi amaçlandı. Gereç ve Yöntem: Çalışmaya Ocak 2015 ve Nisan 2019 tarihleri arasında polikliniğimize başvuran SS tanılı 49 hasta dahil edildi. Hastaların geriye dönük olarak yaş, cinsiyet, SS’nin primer/sekonder olma durumu; sekonder ise hangi hastalığa eşlik ettiği, ilişkili olabilecek diğer kronik hastalıkların varlığı, tükürük bezi biyopsisi ve otoantikor değerlendirme sonuçları kaydedildi. Bulgular: Çalışmaya katılan 49 hastanın (46 kadın, 3 erkek) yaş ortalaması 48,39±11,45 yıl (minimum: 18, maksimum: 81) idi. Kadın/erkek oranı 15,3/1 idi. Hastaların 34’ü (%69,4) primer SS tanısı alırken, 15’i (%30,6) sekonder SS idi. En yaygın başvuru yakınması kuru göz (%98) ve kuru ağız (%92) idi. Çalışmamızda anti-nükleer antikorlar pozitifliği %40,8 olarak saptanırken, romatoid faktör pozitifliği %28,6 idi. Hastaların %46,9’unda Anti-SS-A; %26,5’inde ise anti-SS-B pozitifti. Sonuç: SS’de klinik bulgular, serolojik belirteçler ve semptomlar heterojendir. Hastaların semptom şiddeti ve çeşitliliği diğer eşlik eden romatizmal hastalıklardan da etkilenir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Yılmaz N, demir o (2020). Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. , 58 - 62. 10.4274/tod.galenos.2019.30633
Chicago	Yılmaz Nurdan,demir osman Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. (2020): 58 - 62. 10.4274/tod.galenos.2019.30633
MLA	Yılmaz Nurdan,demir osman Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. , 2020, ss.58 - 62. 10.4274/tod.galenos.2019.30633
AMA	Yılmaz N,demir o Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. . 2020; 58 - 62. 10.4274/tod.galenos.2019.30633
Vancouver	Yılmaz N,demir o Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. . 2020; 58 - 62. 10.4274/tod.galenos.2019.30633
IEEE	Yılmaz N,demir o "Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience." , ss.58 - 62, 2020. 10.4274/tod.galenos.2019.30633
ISNAD	Yılmaz, Nurdan - demir, osman. "Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience". (2020), 58-62. https://doi.org/10.4274/tod.galenos.2019.30633

APA	Yılmaz N, demir o (2020). Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. Türk Osteoporoz Dergisi, 26(2), 58 - 62. 10.4274/tod.galenos.2019.30633
Chicago	Yılmaz Nurdan,demir osman Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. Türk Osteoporoz Dergisi 26, no.2 (2020): 58 - 62. 10.4274/tod.galenos.2019.30633
MLA	Yılmaz Nurdan,demir osman Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. Türk Osteoporoz Dergisi, vol.26, no.2, 2020, ss.58 - 62. 10.4274/tod.galenos.2019.30633
AMA	Yılmaz N,demir o Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. Türk Osteoporoz Dergisi. 2020; 26(2): 58 - 62. 10.4274/tod.galenos.2019.30633
Vancouver	Yılmaz N,demir o Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience. Türk Osteoporoz Dergisi. 2020; 26(2): 58 - 62. 10.4274/tod.galenos.2019.30633
IEEE	Yılmaz N,demir o "Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience." Türk Osteoporoz Dergisi, 26, ss.58 - 62, 2020. 10.4274/tod.galenos.2019.30633
ISNAD	Yılmaz, Nurdan - demir, osman. "Demographic, Clinical and Serological Characteristics of the Patients with Sjögren’s Syndrome: A Tertiary Clinic Experience". Türk Osteoporoz Dergisi 26/2 (2020), 58-62. https://doi.org/10.4274/tod.galenos.2019.30633