Serum Melatonin Levels in Patients with Family Mediterranean Fever

Kul, Ayhan; SARIHAN, Köksal; Baygutalp, Fatih; Ozturk, Nurinnisa

doi:10.4274/tod.galenos.2020.04127

Serum Melatonin Levels in Patients with Family Mediterranean Fever

Ayhan KUL, (Atatürk Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Erzurum, Türkiye)

Nurinnisa ÖZTÜRK, (Atatürk Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Erzurum, Türkiye)

Köksal SARIHAN, (Atatürk Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Erzurum, Türkiye)

Fatih Baygutalp (Atatürk Üniversitesi, Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Erzurum, Türkiye)

Türk Osteoporoz Dergisi

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Yıl: 2020 Cilt: 26 Sayı: 2 Sayfa Aralığı: 92 - 97 Metin Dili: İngilizce DOI: 10.4274/tod.galenos.2020.04127 İndeks Tarihi: 25-11-2020

Serum Melatonin Levels in Patients with Family Mediterranean Fever

Öz:

Objective: Melatonin (MLT) has been reported to play a role in the immunopathogenesis and aetiology of many chronic inflammatory diseases. Therefore, we aimed to investigate the possible relationship between disease severity and serum MLT levels in patients with Familial Mediterranean fever (FMF).Materials and Methods: A total of 30 patients diagnosed with FMF who had experienced no episodes for at least 1 month (mean age, 36.4±12.2 years; range, 19-68 years), including 14 men and 16 women, and 30 healthy controls (mean age, 38.4±12.5 years; range, 19-65 years), 12 men and 18 women, matched for age and gender, were included in this study. Demographic data, laboratory data and clinical characteristics of the participants were recorded and serum MLT levels were determined. In addition, the relationship between serum MLT level and disease severity was evaluated.Results: A significant difference was observed between the groups in terms of serum MLT levels (p<0.05). However, there were no significant relationships between serum MLT levels and demographic data, such as sex and age, and body mass index, erythrocyte sedimentation rate, C-reactive protein and fibrinogen levels and disease severity scores of the FMF patients. There was a statistically significant difference in serum MLT levels between patients having a history of acute arthritis (n=7) and those without arthritis (n=23), (p=0.019).Conclusion: Our findings suggest that MLT may play a possible role in the immunopathogenesis of FMF and those with a history of FMF-related arthritis. However, because the immune regulatory role of MLT is very complex and the mechanisms are not yet fully understood, we think that more comprehensive studies in the future are needed to confirm our findings.

Anahtar Kelime:

Ailevi Akdeniz Ateşi Olan Hastalarda Serum Melatonin Düzeyleri

Öz:

Amaç: Melatoninin (MLT) birçok kronik enflamatuvar hastalığın immünopatogenezinde ve etiyolojisinde rol oynayabileceği bildirildiğinden dolayı, çalışmamızda ailevi akdeniz ateşi (AAA) olan hastaların serum MLT seviyelerinin belirlenerek hastalık şiddeti ile arasında olası bir ilişki olup olmadığını incelemeyi amaçladık. Gereç ve Yöntem: Çalışmaya AAA hastalığı tanısı konulan ve en az 1 aydır (ortalama yaş, 36,4±12,2 yıl; aralık, 19-68 yıl) atak geçirmeyen 14 erkek ve 16 kadın olmak üzere toplam 30 hasta (ortalama yaş, 38,4±12,5 yıl; aralık, 19-65 yıl) ile yaş ve cinsiyetleri benzer olan 12 erkek ve 18 kadın toplam 30 sağlıklı kontrol (ortalama yaş 38,4±12,5 yıl; yaş aralığı; 19-65 yıl) bulunmaktaydı. Katılımcıların demografik verileri, laboratuvar ve klinik özellikleri kaydedilerek, serum MLT seviyeleri belirlendi. Ayrıca serum MLT seviyesi ile hastalık şiddeti arasındaki ilişki değerlendirildi. Bulgular: Gruplar arasında serum MLT seviyeleri açısından anlamlı fark olduğu belirlendi (p<0,05). AAA hastalarının cinsiyet, yaş ve vücut kitle indeksi gibi demografik verileri, eritrosit sedimentasyon hızı, C-reaktif protein ve fibrinojen değerleri ve hastalık şiddet skoru ile serum MLT seviyesi arasında anlamlı bir ilişki bulunmadı. AAA hastalarında artrit varlığına göre; akut artrit öyküsü olanlar (n=7 kişi) ile artriti olmayanlar (n=23 kişi) arasında serum MLT düzeyleri açısından istatistiksel olarak anlamlı fark bulundu (p=0,019). Sonuç: Bulgularımız MLT’nin AAA’nın immünopatogenezinde ve AAA’ya bağlı artrit öyküsü olanlarda olası bir rol oynadığına dair kanıt sunmaktadır. Ancak MLT’nin immün düzenleyici rolü çok karmaşık ve mekanizmaları henüz tam olarak anlaşılamadığından dolayı bulgularımızın gelecekte daha kapsamlı araştırmalarla desteklenmesi gerektiğini düşünüyoruz.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kul A, Ozturk N, SARIHAN K, Baygutalp F (2020). Serum Melatonin Levels in Patients with Family Mediterranean Fever. , 92 - 97. 10.4274/tod.galenos.2020.04127
Chicago	Kul Ayhan,Ozturk Nurinnisa,SARIHAN Köksal,Baygutalp Fatih Serum Melatonin Levels in Patients with Family Mediterranean Fever. (2020): 92 - 97. 10.4274/tod.galenos.2020.04127
MLA	Kul Ayhan,Ozturk Nurinnisa,SARIHAN Köksal,Baygutalp Fatih Serum Melatonin Levels in Patients with Family Mediterranean Fever. , 2020, ss.92 - 97. 10.4274/tod.galenos.2020.04127
AMA	Kul A,Ozturk N,SARIHAN K,Baygutalp F Serum Melatonin Levels in Patients with Family Mediterranean Fever. . 2020; 92 - 97. 10.4274/tod.galenos.2020.04127
Vancouver	Kul A,Ozturk N,SARIHAN K,Baygutalp F Serum Melatonin Levels in Patients with Family Mediterranean Fever. . 2020; 92 - 97. 10.4274/tod.galenos.2020.04127
IEEE	Kul A,Ozturk N,SARIHAN K,Baygutalp F "Serum Melatonin Levels in Patients with Family Mediterranean Fever." , ss.92 - 97, 2020. 10.4274/tod.galenos.2020.04127
ISNAD	Kul, Ayhan vd. "Serum Melatonin Levels in Patients with Family Mediterranean Fever". (2020), 92-97. https://doi.org/10.4274/tod.galenos.2020.04127

APA	Kul A, Ozturk N, SARIHAN K, Baygutalp F (2020). Serum Melatonin Levels in Patients with Family Mediterranean Fever. Türk Osteoporoz Dergisi, 26(2), 92 - 97. 10.4274/tod.galenos.2020.04127
Chicago	Kul Ayhan,Ozturk Nurinnisa,SARIHAN Köksal,Baygutalp Fatih Serum Melatonin Levels in Patients with Family Mediterranean Fever. Türk Osteoporoz Dergisi 26, no.2 (2020): 92 - 97. 10.4274/tod.galenos.2020.04127
MLA	Kul Ayhan,Ozturk Nurinnisa,SARIHAN Köksal,Baygutalp Fatih Serum Melatonin Levels in Patients with Family Mediterranean Fever. Türk Osteoporoz Dergisi, vol.26, no.2, 2020, ss.92 - 97. 10.4274/tod.galenos.2020.04127
AMA	Kul A,Ozturk N,SARIHAN K,Baygutalp F Serum Melatonin Levels in Patients with Family Mediterranean Fever. Türk Osteoporoz Dergisi. 2020; 26(2): 92 - 97. 10.4274/tod.galenos.2020.04127
Vancouver	Kul A,Ozturk N,SARIHAN K,Baygutalp F Serum Melatonin Levels in Patients with Family Mediterranean Fever. Türk Osteoporoz Dergisi. 2020; 26(2): 92 - 97. 10.4274/tod.galenos.2020.04127
IEEE	Kul A,Ozturk N,SARIHAN K,Baygutalp F "Serum Melatonin Levels in Patients with Family Mediterranean Fever." Türk Osteoporoz Dergisi, 26, ss.92 - 97, 2020. 10.4274/tod.galenos.2020.04127
ISNAD	Kul, Ayhan vd. "Serum Melatonin Levels in Patients with Family Mediterranean Fever". Türk Osteoporoz Dergisi 26/2 (2020), 92-97. https://doi.org/10.4274/tod.galenos.2020.04127