Objective: Pain is the most common symptom of the breast and accounts for 47% of breast related visits. Although hormonal, pathologic, nutritional, and psychiatric aspects of breast pain in females extensively researched, to the best of our knowledge breast pain in males has not been studied. Our aim in this study is to investigate clinical features of male breast pain and compare them with female breast pain. Materials and Methods: Patients who admitted to our department’s breast clinic due to breast pain between October 2014 and September 2017 included into the study. Clinical features of the male breast pain were collected and compared with female breast pain patients. Results: There were 10 male and 40 female patients. Mean age was 55 ± 23 and 43.4 ± 13 years; the mean pain intensity score was 4.2 ± 2.2 and 5.2 ± 2.1 for the male and female patients respectively. Sonography revealed 12 (30 %) simple cyst, 2 (5 %) complex cyst, 12 (30 %) solid mass, 2 (5 %) mastitis, and 12 (30 %) normal findings in the female patients; and 9 (90 %) gynecomastia and 1 pseudo-gynecomastia (10%) in the male patients. Conclusion: To the best of our knowledge, this article is the first article in the literature investigating male breast pain and comparing them with female breast pain. We found that majority of males who present with breast pain have underlying gynecomastia. Physicians should consider gynecomastia in the differential diagnosis of male breast pain and perform a breast examination in addition to a detailed patient history.