The Effect of Bisphosphonates on Lumbar Vertebral Disc Height

DÜBEKTAŞ CANBEK, TUĞBA; karalezli, nazim; Aydogan, Nevres Hurriyet; Akgun, Ulas; Comert, Ayhan; Rosberg, Hans-Eric; Canbek, Umut; HAZER, Derya Burcu

The Effect of Bisphosphonates on Lumbar Vertebral Disc Height

Umut CANBEK, (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, Ortopedi Bölümü, Muğla, Türkiye)

Derya Burcu HAZER, (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi Nöroşirürji Anabilim Dalı, Muğla, Türkiye)

Hans-Eric ROSBERG, (Lund University, Skane University Hospital, Department of Translational Medicine, Malmö, Sweden)

Ulaş AKGÜN, (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, Ortopedi Bölümü, Muğla, Türkiye)

Tugba Dubektas CANBEK, (Muğla Sıtkı Koçman Üniversitesi Eğitim ve Araştırma Hastanesi İç Hastalıkları Kliniği, Muğla, Türkiye)

AYHAN CÖMERT, (Ankara Üniversitesi Tıp Fakültesi, Anatomi Anabilim Dalı, Ankara, Türkiye.)

Nazım KARALEZLİ, (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi Ortopedi ve Travmatoloji Anabilim Dalı, Ortopedi Bölümü, Muğla, Türkiye.)

Nevres Hürriyet AYDOĞAN (Muğla Sıtkı Koçman Üniversitesi Tıp Fakültesi, Ortopedi Anabilim Dalı, Ortopedi ve Travmatoloji Bölümü, Muğla, Türkiye.)

Ege Klinikleri Tıp Dergisi

9 0

Yıl: 2019 Cilt: 57 Sayı: 1 Sayfa Aralığı: 52 - 56 Metin Dili: İngilizce İndeks Tarihi: 25-11-2020

The Effect of Bisphosphonates on Lumbar Vertebral Disc Height

Öz:

Objective: Our purpose was to investigate the effect of bisphosphonates on the lumbar disc height, based on quantitative magnetic resonance imaging measurements in osteoporotic patients. Materials and Methods: A total of 74 patients with osteopenia or osteoporosis were retrospectively included in the study. Thirty-seven patients received bisphosphonate treatment and 37 did not receive any treatment. Age, body mass index scores, spine and hip T scores of the patients together with the median values of the disc heights in six lumbar intervertebral levels (T12–L1 to L5–S1) were analyzed. Results: The bisphosphonate treated group were significantly older compared to the untreated group. However, there was no statistically significant difference in BMI scores between the groups. The spine-T-scores were significantly lower in the bisphosphonate treated group compared to the untreated group, but the hip T scores were found to be similar. The correlation analysis in the untreated group revealed a very weak positive correlation between the disc heights and the spine T scores except for the discs between L4-5 and L3-4. Conclusion: We found that, bisphosphonate therapy might be associated with the preserving of the lumbar disc height despite of low bone mineral density levels.

Anahtar Kelime:

Bifosfanatların Lomber Vertebra Disk Yüksekliği Üzerine Etkisi

Öz:

Amaç: Amacımız, osteoporotik hastalarda kantitatif manyetik rezonans görüntüleme ölçümlerine dayanarak bifosfonatların lomber disk yüksekliği üzerindeki etkisini araştırmaktır. Gereç ve yöntem: Kliniğimizde Ocak 2017 - Ocak 2018 arasında muayene edilen osteopenik veya osteoporotik toplam 74 hasta çalışmaya alındı. Bu 74 hastanın 37 ‘si son dönemde bifosfasfanat kullanmışken, bunların 37'sinde bifosfanat kullanım öyküsü yoktu. Hastaların yaş, boy, kilo, vücut kitle indeksi (VKİ) skorları, omurga ve kalça T skorları ile birlikte altı lomber intervertebral seviyede (T12 – L1 - L5 – S1) disk yüksekliklerinin medyan değerleri incelendi. Bulgular: Bifosfonat ile tedavi edilen grup tedavi edilmeyen gruba göre daha yaşlı, daha kısa ve daha inceydi (Welch t-testi, p = 0,038, p <0,001, p <0,001). Bununla birlikte, gruplar arasındaki BMI skorları açısından istatistiksel olarak anlamlı bir fark yoktu. Omurga T skorları, bifosfonatla tedavi edilen grupta (Welch t-testi, p = 0,016) tedavi edilmeyen gruba göre anlamlı olarak daha düşüktü, ancak kalça T skorları benzer bulundu. Tedavi edilmeyen gruptaki korelasyon analizi, tüm seviye disk yüksekliklerinde ve L4-5 ve L3-4 düzeyleri dışındaki omurga T skorlarında pozitif bir korelasyon olduğunu ortaya koymuştur. Sonuç: Bifosfonat tedavisinin düşük kemik mineral yoğunluğu düzeylerine rağmen lomber disk yüksekliğini korumayla ilişkili olduğunu bulduk.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık

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APA	Canbek U, HAZER D, Rosberg H, Akgun U, DÜBEKTAŞ CANBEK T, Comert A, karalezli n, Aydogan N (2019). The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. , 52 - 56.
Chicago	Canbek Umut,HAZER Derya Burcu,Rosberg Hans-Eric,Akgun Ulas,DÜBEKTAŞ CANBEK TUĞBA,Comert Ayhan,karalezli nazim,Aydogan Nevres Hurriyet The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. (2019): 52 - 56.
MLA	Canbek Umut,HAZER Derya Burcu,Rosberg Hans-Eric,Akgun Ulas,DÜBEKTAŞ CANBEK TUĞBA,Comert Ayhan,karalezli nazim,Aydogan Nevres Hurriyet The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. , 2019, ss.52 - 56.
AMA	Canbek U,HAZER D,Rosberg H,Akgun U,DÜBEKTAŞ CANBEK T,Comert A,karalezli n,Aydogan N The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. . 2019; 52 - 56.
Vancouver	Canbek U,HAZER D,Rosberg H,Akgun U,DÜBEKTAŞ CANBEK T,Comert A,karalezli n,Aydogan N The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. . 2019; 52 - 56.
IEEE	Canbek U,HAZER D,Rosberg H,Akgun U,DÜBEKTAŞ CANBEK T,Comert A,karalezli n,Aydogan N "The Effect of Bisphosphonates on Lumbar Vertebral Disc Height." , ss.52 - 56, 2019.
ISNAD	Canbek, Umut vd. "The Effect of Bisphosphonates on Lumbar Vertebral Disc Height". (2019), 52-56.

APA	Canbek U, HAZER D, Rosberg H, Akgun U, DÜBEKTAŞ CANBEK T, Comert A, karalezli n, Aydogan N (2019). The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. Ege Klinikleri Tıp Dergisi, 57(1), 52 - 56.
Chicago	Canbek Umut,HAZER Derya Burcu,Rosberg Hans-Eric,Akgun Ulas,DÜBEKTAŞ CANBEK TUĞBA,Comert Ayhan,karalezli nazim,Aydogan Nevres Hurriyet The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. Ege Klinikleri Tıp Dergisi 57, no.1 (2019): 52 - 56.
MLA	Canbek Umut,HAZER Derya Burcu,Rosberg Hans-Eric,Akgun Ulas,DÜBEKTAŞ CANBEK TUĞBA,Comert Ayhan,karalezli nazim,Aydogan Nevres Hurriyet The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. Ege Klinikleri Tıp Dergisi, vol.57, no.1, 2019, ss.52 - 56.
AMA	Canbek U,HAZER D,Rosberg H,Akgun U,DÜBEKTAŞ CANBEK T,Comert A,karalezli n,Aydogan N The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. Ege Klinikleri Tıp Dergisi. 2019; 57(1): 52 - 56.
Vancouver	Canbek U,HAZER D,Rosberg H,Akgun U,DÜBEKTAŞ CANBEK T,Comert A,karalezli n,Aydogan N The Effect of Bisphosphonates on Lumbar Vertebral Disc Height. Ege Klinikleri Tıp Dergisi. 2019; 57(1): 52 - 56.
IEEE	Canbek U,HAZER D,Rosberg H,Akgun U,DÜBEKTAŞ CANBEK T,Comert A,karalezli n,Aydogan N "The Effect of Bisphosphonates on Lumbar Vertebral Disc Height." Ege Klinikleri Tıp Dergisi, 57, ss.52 - 56, 2019.
ISNAD	Canbek, Umut vd. "The Effect of Bisphosphonates on Lumbar Vertebral Disc Height". Ege Klinikleri Tıp Dergisi 57/1 (2019), 52-56.