Yıl: 2020 Cilt: 48 Sayı: 4 Sayfa Aralığı: 368 - 373 Metin Dili: İngilizce DOI: 10.5543/tkda.2019.99789 İndeks Tarihi: 25-11-2020

Analysis of thrombophilic gene mutations in coronary artery ectasia

Öz:
Objective: Coronary artery ectasia (CAE) is defined as localized or diffuse dilatation in the coronary artery lumen of at least1.5 times the diameter of adjacent healthy reference segments. The etiology of CAE is still unknown, but the most likelycause is atherosclerosis. The aim of this study was to evaluateseveral gene polymorphisms that are thought to have an effect on the development of coronary atherosclerosis and havebeen shown to cause thrombophilia in CAE patients.Methods: The factor V Leiden (G1691A), factor V H1299R,prothrombin G20210A, factor XIII V34L, beta-fibrinogen-455G>A, plasminogen activator inhibitor (PAI)-1 4G/5G, andmethylenetetrahydrofolate reductase (MTHFR) C677T, andMTHFR A1298C polymorphisms were evaluated in 66 patients with CAE and 32 individuals with normal coronaryarteries.Results: Comparison of the CAE and control groups revealed that the clinical features and the frequency of polymorphism in the thrombophilic genes were similar in bothgroups. However, when heterozygous and/or homozygouspolymorphism was compared between groups, it was foundthat there was a significantly higher finding of thrombophilicgene polymorphism in the CAE group (p=0.023).Conclusion: Thrombophilic gene polymorphism may be associated with the formation and clinical presentation of CAE.
Anahtar Kelime:

Koroner arter ektazisinde trombofilik gen mutasyon analizi

Öz:
Amaç: Koroner arter ektazisi (KAE), koroner arterin lümeninin lokalize veya yaygın olarak dilatasyonu olup, sağlıklı komşu damar segment çapınına göre en az 1.5 kat dilate olması olarak tanımlanmıştır. KAE’nin etiyolojisi hala tam olarak bilinmemektedir, ancak en olası nedenin ateroskleroz olduğu gösterilmiştir. Bu çalışmada, KAE hastalarında koroner ateroskleroz gelişiminde etkili olduğu düşünülen ve trombofiliye yol açtığı gösterilmiş bazı gen polimorfizmlerini değerlendirmeyi amaçladık. Yöntemler: Çalışmamızda KAE (n=66) ve kontrol (normal koroner arter) (n=32) grubundaki 98 hastada trombofili genleri olarak bilinen Faktör V Leiden (G1691A), Faktör V H1299R, Protrombin G20210A, Faktör XIII V34L, B-Fibrinojen-455 G> A, PAI-1 4G/5G, MTHFR C677T ve MTHFR A1298C polimorfizmi değerlendirildi. Bulgular: Gruplar karşılaştırıldığında klinik özellikleri ve trombofilik genlerdeki polimorfizm sıklığı her iki grupta benzer olduğu görüldü. Ancak, gruplar arasında heterozigot ve/ veya homozigot polimorfizmi olup olmayanlar karşılaştırıldığında, KAE grubunda trombofilik gen polimorfizm olanlar anlamlı olarak daha fazla görüldü (p=0.023). Sonuç: Trombofilik gen polimorfizmi, KAE oluşumu ve klinik görünümü ile ilişkili olabilir.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA yalım z, Tutgun Onrat S, emren v, Dural İ, Avsar A, Onrat E (2020). Analysis of thrombophilic gene mutations in coronary artery ectasia. , 368 - 373. 10.5543/tkda.2019.99789
Chicago yalım zafer,Tutgun Onrat Serap,emren volkan,Dural İbrahim Etem,Avsar Alaettin,Onrat Ersel Analysis of thrombophilic gene mutations in coronary artery ectasia. (2020): 368 - 373. 10.5543/tkda.2019.99789
MLA yalım zafer,Tutgun Onrat Serap,emren volkan,Dural İbrahim Etem,Avsar Alaettin,Onrat Ersel Analysis of thrombophilic gene mutations in coronary artery ectasia. , 2020, ss.368 - 373. 10.5543/tkda.2019.99789
AMA yalım z,Tutgun Onrat S,emren v,Dural İ,Avsar A,Onrat E Analysis of thrombophilic gene mutations in coronary artery ectasia. . 2020; 368 - 373. 10.5543/tkda.2019.99789
Vancouver yalım z,Tutgun Onrat S,emren v,Dural İ,Avsar A,Onrat E Analysis of thrombophilic gene mutations in coronary artery ectasia. . 2020; 368 - 373. 10.5543/tkda.2019.99789
IEEE yalım z,Tutgun Onrat S,emren v,Dural İ,Avsar A,Onrat E "Analysis of thrombophilic gene mutations in coronary artery ectasia." , ss.368 - 373, 2020. 10.5543/tkda.2019.99789
ISNAD yalım, zafer vd. "Analysis of thrombophilic gene mutations in coronary artery ectasia". (2020), 368-373. https://doi.org/10.5543/tkda.2019.99789
APA yalım z, Tutgun Onrat S, emren v, Dural İ, Avsar A, Onrat E (2020). Analysis of thrombophilic gene mutations in coronary artery ectasia. Türk Kardiyoloji Derneği Arşivi, 48(4), 368 - 373. 10.5543/tkda.2019.99789
Chicago yalım zafer,Tutgun Onrat Serap,emren volkan,Dural İbrahim Etem,Avsar Alaettin,Onrat Ersel Analysis of thrombophilic gene mutations in coronary artery ectasia. Türk Kardiyoloji Derneği Arşivi 48, no.4 (2020): 368 - 373. 10.5543/tkda.2019.99789
MLA yalım zafer,Tutgun Onrat Serap,emren volkan,Dural İbrahim Etem,Avsar Alaettin,Onrat Ersel Analysis of thrombophilic gene mutations in coronary artery ectasia. Türk Kardiyoloji Derneği Arşivi, vol.48, no.4, 2020, ss.368 - 373. 10.5543/tkda.2019.99789
AMA yalım z,Tutgun Onrat S,emren v,Dural İ,Avsar A,Onrat E Analysis of thrombophilic gene mutations in coronary artery ectasia. Türk Kardiyoloji Derneği Arşivi. 2020; 48(4): 368 - 373. 10.5543/tkda.2019.99789
Vancouver yalım z,Tutgun Onrat S,emren v,Dural İ,Avsar A,Onrat E Analysis of thrombophilic gene mutations in coronary artery ectasia. Türk Kardiyoloji Derneği Arşivi. 2020; 48(4): 368 - 373. 10.5543/tkda.2019.99789
IEEE yalım z,Tutgun Onrat S,emren v,Dural İ,Avsar A,Onrat E "Analysis of thrombophilic gene mutations in coronary artery ectasia." Türk Kardiyoloji Derneği Arşivi, 48, ss.368 - 373, 2020. 10.5543/tkda.2019.99789
ISNAD yalım, zafer vd. "Analysis of thrombophilic gene mutations in coronary artery ectasia". Türk Kardiyoloji Derneği Arşivi 48/4 (2020), 368-373. https://doi.org/10.5543/tkda.2019.99789