Yıl: 2019 Cilt: 25 Sayı: 1 Sayfa Aralığı: 39 - 43 Metin Dili: İngilizce DOI: DOI: 10.5152/EurJTher.2018.701 İndeks Tarihi: 26-11-2020

The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis

Öz:
Objective: The aim of the present study was to investigate the frequency of celiac disease (CD) in children with cystic fibrosis (CF). Methods: This prospective study was conducted from October 2015 to March 2017. A total of 71 patients with CF and 73 age- and sexmatched healthy children were included in the study. All groups were evaluated for CD with regard to clinical and laboratory findings. First, total IgA and tissue transglutaminase IgA (tTG IgA) levels were measured. Anti-endomysium IgA antibodies (EMAs) were analyzed for those patients with positive tTG IgA. Gastroduodenoscopy was performed to patients with both positive tTG and EMA IgA. Results: Only 8 (11.2%) patients had tTG IgA positivity, whereas 4 (5.6%) patients had positive EMA. The pathological results were consistent with the Marsh 2 classification score in two patients. In addition to that, HLA-DQ2 is present in those two patients. Those patients were accepted as potential CD. Two patients who were thought to have potential CD were reassessed after 1 year, and celiac screening tests were detected as positive again. Conclusion: Only 2 (2.8%) of 71 patients with CF were diagnosed with potential CD. Our study results showed that there might be an association between CD and CF.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Genkova ND, Yankov IV, Bosheva MN, Anavi BL, Grozeva DG, Dzhelepova NG. Cystic fibrosis and celiac disease-multifaceted and similar. Folia Medica 2013; 55: 87-9.
  • Kostovski A, Zdraveska N. Coagulopathy as initial manifestation of concomitant celiac disease and cystic fibrosis: a case report. J Med Case Rep 2011; 5: 116.
  • Husby S, Koletzko S, Korponay-Szabo IR, Mearin M, Phillips A, Shamir R, et al. ESPGHAN guidelines for the diagnosis celiac disease in children and adolescents: an evidence-based approach. J Pediatr Gastroenterol Nutr 2012; 54: 136-60.
  • Gujral N, Freeman HJ, Thomson ABR. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol 2012; 18: 6036-59.
  • Garnier-Lengline H, Cerf-Bensussan N, Ruemmele FM. Celiac disease in children. Clin Res Hepatol Gastroenterol 2015; 39: 544-51.
  • Fluge G, Olesen HV, Giljam M, Meyer P, Pressler T, Storrösten OT, et al. Co-morbidity of cystic fibrosis and celiac disease in Scandinavian cystic fibrosis patients. J Cyst Fibros 2009; 8: 198-202.
  • Walkowiak J, Blask-Osipa A, Lisowska A, Oralewska B, Pogorzelski A, Cichy W, et al. Cystic fibrosis is a risk factor for celiac disease. Acta Biochim Pol 2010; 57: 115-8.
  • Littlewood JM. Coeliac disease in childhood. J R Soc Med 1995; 88: 9-17.
  • Valleta EA, Mastella G. Incidence of celiac disease in a cystic fibrosis population. Acta Paediatr Scand 1989; 78: 784-5.
  • 10. Rosenstein BJ, Cutting GR. The diagnosis of cystic fibrosis: a consensus statement. Cystic Fibrosis Foundation Consensus Panel. J Pediatr 1998; 132: 589-95.
  • 11. Marsh MN. Gluten, major histocompatibility complex, and the small intestine: a molecular and immunobiologic approach to the spectrum of gluten sensitivity (celiac sprue). Gastroenterology 1992; 102: 330-54.
  • 12. Available from: http://www.genet.sickkids.on.ca/cftr.
  • 13. Farrell PM, Rosenstein BJ, White TB, Accurso FJ, Castellani C, Cutting GR, et al. Cystic Fibrosis Foundation. Guidelines for diagnosis of cystic fibrosis in newborns through older adults: Cystic Fibrosis Foundation consensus report. J Pediatr 2008; 153: S4-14.
  • 14. Rubio-Tapia A, Kyle RA, Kaplan EL, Johnson DR, Page W, Erdtmann F, et al. Increased prevalence and mortality in undiagnosed celiac disease. Gastroenterology 2009; 137: 88-93.
  • 15. Lohi S, Mustalahti K, Kaukinen K, Laurila K, Collin P, Rissanen H, et al. Increasing prevalence of coeliac disease over time. Aliment Pharmacol Ther 2007; 26: 1217-25.
  • 16. Murch S, Jenkins H, Auth M, Bremner R, Butt A, France S, et al.; BSPGHAN. Joint BSPGHAN and Coeliac UK guidelines for the diagnosis and management of coeliac disease in children. Arch Dis Child 2013; 98: 806-11.
  • 17. Corrao G, Corazza GR, Bagnardi V, Brusco G, Ciacci C, Cottone M, et al. Mortality in patients with coeliac disease and their relatives: a cohort study. Lancet 2001; 358: 356-61.
  • 18. West J, Logan RF, Smith CJ, Hubbard RB, Card TR. Malignancy and mortality in people with coeliac disease: population based cohort study. BMJ 2004; 329: 716-9.
  • 19. Ventura A, Magazzu G, Greco L. Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease. Gastroenterology 1999; 117: 297-303.
  • 20. Di Sabatino A, Corazza GR. Coeliac disease. Lancet 2009; 373: 148093.
  • 21. Venuta A, Bertolani P, Casarini R, Ferrari F, Guaraldi N, Garetti E. Coexistence of cystic fibrosis and celiac disease. Description of a clinical case and review of the literature. Pediatr Med Chir 1999; 21: 223-6.
  • 22. Giersiepen K, Lelgemann M, Stuhldreher N, Ronfani L, Husby S, Koletzko S, et al.; ESPGHAN Working Group on Coeliac Disease Diagnosis. Accuracy of diagnostic antibody tests for coeliac disease in children: summary of an evidence report. J Pediatr Gastroenterol Nutr 2012; 54: 229-41.
  • 23. Hill ID. What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 2005; 128: S25-32.
  • 24. Tosco A, Salvati VM, Auricchio R, Maglio M, Borrelli M, Coruzzo A, et al. Natural history of potential celiac disease in children. Clin Gastroenterol Hepatol 2011; 9: 320-5.
  • 25. Kurppa K, Ashorn M, Iltanen S, Koskinen LL, Saavalainen P, Koskinen O, et al. Celiac disease without villous atrophy in children: a prospective study. J Pediatr 2010; 157: 373-80.
  • 26. Dalgic B, Sari S, Basturk B, Ensari A, Egritas O, Bukulmez A, et al.; Turkish Celiac Study Group. Prevelance of celiac disease in healthy Turkish school children. Am J Gastroenterol 2011; 106: 1512-7.
APA sahin y, Erkan T, Kutlu T, kepil n, Atabek A, Cullu Cokugras F, cokugras H (2019). The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. , 39 - 43. DOI: 10.5152/EurJTher.2018.701
Chicago sahin yasin,Erkan Tulay,Kutlu Tufan,kepil nuray,Atabek Ayse Ayzit,Cullu Cokugras Fugen,cokugras Haluk Cezmi The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. (2019): 39 - 43. DOI: 10.5152/EurJTher.2018.701
MLA sahin yasin,Erkan Tulay,Kutlu Tufan,kepil nuray,Atabek Ayse Ayzit,Cullu Cokugras Fugen,cokugras Haluk Cezmi The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. , 2019, ss.39 - 43. DOI: 10.5152/EurJTher.2018.701
AMA sahin y,Erkan T,Kutlu T,kepil n,Atabek A,Cullu Cokugras F,cokugras H The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. . 2019; 39 - 43. DOI: 10.5152/EurJTher.2018.701
Vancouver sahin y,Erkan T,Kutlu T,kepil n,Atabek A,Cullu Cokugras F,cokugras H The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. . 2019; 39 - 43. DOI: 10.5152/EurJTher.2018.701
IEEE sahin y,Erkan T,Kutlu T,kepil n,Atabek A,Cullu Cokugras F,cokugras H "The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis." , ss.39 - 43, 2019. DOI: 10.5152/EurJTher.2018.701
ISNAD sahin, yasin vd. "The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis". (2019), 39-43. https://doi.org/DOI: 10.5152/EurJTher.2018.701
APA sahin y, Erkan T, Kutlu T, kepil n, Atabek A, Cullu Cokugras F, cokugras H (2019). The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. European Journal of Therapeutics, 25(1), 39 - 43. DOI: 10.5152/EurJTher.2018.701
Chicago sahin yasin,Erkan Tulay,Kutlu Tufan,kepil nuray,Atabek Ayse Ayzit,Cullu Cokugras Fugen,cokugras Haluk Cezmi The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. European Journal of Therapeutics 25, no.1 (2019): 39 - 43. DOI: 10.5152/EurJTher.2018.701
MLA sahin yasin,Erkan Tulay,Kutlu Tufan,kepil nuray,Atabek Ayse Ayzit,Cullu Cokugras Fugen,cokugras Haluk Cezmi The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. European Journal of Therapeutics, vol.25, no.1, 2019, ss.39 - 43. DOI: 10.5152/EurJTher.2018.701
AMA sahin y,Erkan T,Kutlu T,kepil n,Atabek A,Cullu Cokugras F,cokugras H The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. European Journal of Therapeutics. 2019; 25(1): 39 - 43. DOI: 10.5152/EurJTher.2018.701
Vancouver sahin y,Erkan T,Kutlu T,kepil n,Atabek A,Cullu Cokugras F,cokugras H The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis. European Journal of Therapeutics. 2019; 25(1): 39 - 43. DOI: 10.5152/EurJTher.2018.701
IEEE sahin y,Erkan T,Kutlu T,kepil n,Atabek A,Cullu Cokugras F,cokugras H "The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis." European Journal of Therapeutics, 25, ss.39 - 43, 2019. DOI: 10.5152/EurJTher.2018.701
ISNAD sahin, yasin vd. "The Frequency of Celiac Disease in Turkish Children with Cystic Fibrosis". European Journal of Therapeutics 25/1 (2019), 39-43. https://doi.org/DOI: 10.5152/EurJTher.2018.701