The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients

erdiş, eda; Yücel, Birsen; GÜLER AVCI, GÜLHAN

doi:10.5505/tjo.2020.2240

The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients

Gülhan GÜLER AVCI, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Tokat, Türkiye)

Birsen YÜCEL, (Cumhuriyet Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Sivas, Türkiye)

Eda ERDİŞ (Cumhuriyet Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Sivas, Türkiye)

Türk Onkoloji Dergisi

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Yıl: 2020 Cilt: 35 Sayı: 3 Sayfa Aralığı: 242 - 249 Metin Dili: İngilizce DOI: 10.5505/tjo.2020.2240 İndeks Tarihi: 26-11-2020

The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients

Öz:

OBJECTIVEThe present study aims to investigate the radiation-related toxicity and its effects on the quality of life inpatients with prostate cancer who received definitive or adjuvant radiotherapy (RT).METHODSEighty-seven localized prostate cancer patients who underwent RT between January 2011 and June 2016were enrolled. Each patient filled the EORTC QLQC30 and QLQ-PR25 at four different times (startingand ending at RT, one and six months after RT). EORTC QLQ-C30 questionnaire consists of globalhealth status, five functional (physical, role, cognitive, emotional, social) and nine symptom scales (fatiguenausea/vomiting, pain, dyspnea, insomnia, appetite loss, constipation, diarrhea and financial difficulties).EORTC QLQ-PR25 consists of two functional (sexual activity and sexual functioning) and foursymptom scales (urinary, bowel, hormonal treatment-related, incontinence aid).RESULTSAccording to the EORTC QLQ-C30 questionnaire, global health status score (p=0.007), emotional score(p=0.016), fatigue (p=0.004) and diarrhea score (p=0.003); according to EORTC QLQPR25 questionnaire,urinary score (p=0.024) were significantly poorer at the end of RT. When patients’ quality of lifequestionnaires were compared concerning treatment type (definitive vs. adjuvant RT), RT technique(3D CRT vs. IMRT) and RT field (prostate/prostate+seminal vesicle vs. prostate+seminal vesicle+pelviclymph node); EORTC QLQ C-30 and EORTC QLQ PR-25 functional and symptom scales were not differentbetween groups.CONCLUSIONThe RT approach in prostate cancer produced temporary impairment in some scores of QLQ, but allthese scores showed improvement from the first month after RT.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Crawford ED. Epidemiology of prostate cancer. Urology 2003;62(6 Suppl 1):3–12.
2. Wilt TJ, MacDonald R, Rutks I, Shamliyan TA, Taylor BC, Kane RL. Systematic review: comparative effectiveness and harms of treatments for clinically localized prostate cancer [published correction appears in Ann Intern Med. 2008 Jun 3;148(11):888]. Ann Intern Med 2008;148(6):435–48.
3. Bolla M, Collette L, Blank L, Warde P, Dubois JB, Mirimanoff RO, et al. Long-term results with immediate androgen suppression and external irradiation in patients with locally advanced prostate cancer (an EORTC study): a phase III randomised trial. Lancet 2002;360(9327):103–6.
4. Heidenreich A, Aus G, Bolla M, Joniau S, Matveev VB, Schmid HP, Zattoni F; European Association of Urology. EAU guidelines on prostate cancer. Eur Urol 2008;53(1):68–80.
5. Peeters ST, Heemsbergen WD, Koper PC, van Putten WL, Slot A, Dielwart MF, et al. Dose-response in radiotherapy for localized prostate cancer: results of the Dutch multicenter randomized phase III trial comparing 68 Gy of radiotherapy with 78 Gy. J Clin Oncol 2006;24(13):1990–6.
6. Zietman AL, DeSilvio ML, Slater JD, Rossi CJ Jr, Miller DW, Adams JA, et al. Comparison of conventionaldose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: a randomized controlled trial. JAMA 2005;294(10):1233–9.
7. Pollack A, Zagars GK, Starkschall G, Antolak JA, Lee JJ, Huang E, et al. Prostate cancer radiation dose response: results of the M. D. Anderson phase III randomized trial. Int J Radiat Oncol Biol Phys 2002;53(5):1097–105.
8. Ling CC, Burman C, Chui CS, Kutcher GJ, Leibel SA, LoSasso T, et al. Conformal radiation treatment of prostate cancer using inversely-planned intensitymodulated photon beams produced with dynamic multileaf collimation. Int J Radiat Oncol Biol Phys 1996;35(4):721–30.
9. Chauvet I, Gaboriaud G, Pontvert D, Zefkili S, Giraud P, Rosenwald JC, et al. Constraints and dosage for prostate cancer patients treated with conformal radiotherapy and intensity modulated radiation therapy. Cancer Radiother 2004;8(6):337–51.
10. Zelefsky MJ, Fuks Z, Hunt M, Yamada Y, Marion C, Ling CC, et al. High-dose intensity modulated radiation therapy for prostate cancer: early toxicity and biochemical outcome in 772 patients. Int J Radiat Oncol Biol Phys 2002;53(5):1111–6.
11. Fayers P, Aaronson NK, Bjordal K, Groenvold M, Curran D, Bottomley A. EORTC QLO-C30 scoring manual. 3rd ed. Brussels: European Organisation for Research and Tretament Cancer Data Center; 2001.
12. Borghede G, Sullivan M. Measurement of quality of life in localized prostatic cancer patients treated with radiotherapy. Development of a prostate cancer-specific module supplementing the EORTC QLQ-C30. Qual Life Res 1996;5(2):212–22.
13. van Andel G, Bottomley A, Fosså SD, Efficace F, Coens C, Guerif S, et al. An international field study of the EORTC QLQ-PR25: a questionnaire for assessing the health-related quality of life of patients with prostate cancer. Eur J Cancer 2008;44(16):2418–24.
14. Cox JD, Stetz J, Pajak TF. Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC). Int J Radiat Oncol Biol Phys 1995;31(5):1341–6.
15. Aaronson NK, Ahmedzai S, Bergman B, Bullinger M, Cull A, Duez NJ, et al. The European Organization for Research and Treatment of Cancer QLQ-C30: a quality- of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst 1993;85(5):365– 76.
16. Marchand V, Bourdin S, Charbonnel C, Rio E, Munos C, Campion L, et al. No impairment of quality of life 18 months after high-dose intensity-modulated radiotherapy for localized prostate cancer: a prospective study. Int J Radiat Oncol Biol Phys 2010;77(4):1053–9.
17. Goineau A, Marchand V, Rigaud J, Bourdin S, Rio E, Campion L, et al. Prospective evaluation of quality of life 54 months after high-dose intensity-modulated radiotherapy for localized prostate cancer. Radiat Oncol 2013;8:53.
18. Little DJ, Kuban DA, Levy LB, Zagars GK, Pollack A. Quality-of-life questionnaire results 2 and 3 years after radiotherapy for prostate cancer in a randomized dose-escalation study. Urology 2003;62(4):707–13.
19. Namiki S, Ishidoya S, Tochigi T, Kawamura S, Kuwahara M, Terai A, et al. Health-related quality of life after intensity modulated radiation therapy for localized prostate cancer: comparison with conventional and conformal radiotherapy. Jpn J Clin Oncol 2006;36(4):224–30.
20. Wahlgren T, Brandberg Y, Häggarth L, Hellström M, Nilsson S. Health-related quality of life in men after treatment of localized prostate cancer with external beam radiotherapy combined with (192)ir brachytherapy: a prospective study of 93 cases using the EORTC questionnaires QLQ-C30 and QLQ-PR25. Int J Radiat Oncol Biol Phys 2004;60(1):51–9.
21. Korfage IJ, Essink-Bot ML, Borsboom GJ, Madalinska JB, Kirkels WJ, Habbema JD, et al. Five-year follow- up of health-related quality of life after primary treatment of localized prostate cancer. Int J Cancer 2005;116(2):291–6.
22. Yoshimura K, Arai Y, Ichioka K, Matsui Y, Ogura K, Terai A. A 3-y prospective study of health-related and disease-specific quality of life in patients with nonmetastatic prostate cancer treated with radical prostatectomy or external beam radiotherapy. Prostate Cancer Prostatic Dis 2004;7(2):144–51.
23. Lips I, Dehnad H, Kruger AB, van Moorselaar J, van der Heide U, Battermann J, et al. Health-related quality of life in patients with locally advanced prostate cancer after 76 Gy intensity-modulated radiotherapy vs. 70 Gy conformal radiotherapy in a prospective and longitudinal study. Int J Radiat Oncol Biol Phys 2007;69(3):656–61.
24. Majewski W, Tabor K, Prokop E, Kulik R. Quality of life in patients with prostate cancer treated with radical image-guided radiotherapy. Contemp Oncol (Pozn) 2014;18(4):285–9.
25. Pinkawa M, Piroth MD, Holy R, Fischedick K, Klotz J, Székely-Orbán D, et al. Quality of life after whole pelvic versus prostate-only external beam radiotherapy for prostate cancer: a matched-pair comparison. Int J Radiat Oncol Biol Phys 2011;81(1):23–8.

APA	GÜLER AVCI G, Yücel B, erdiş e (2020). The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. , 242 - 249. 10.5505/tjo.2020.2240
Chicago	GÜLER AVCI GÜLHAN,Yücel Birsen,erdiş eda The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. (2020): 242 - 249. 10.5505/tjo.2020.2240
MLA	GÜLER AVCI GÜLHAN,Yücel Birsen,erdiş eda The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. , 2020, ss.242 - 249. 10.5505/tjo.2020.2240
AMA	GÜLER AVCI G,Yücel B,erdiş e The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. . 2020; 242 - 249. 10.5505/tjo.2020.2240
Vancouver	GÜLER AVCI G,Yücel B,erdiş e The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. . 2020; 242 - 249. 10.5505/tjo.2020.2240
IEEE	GÜLER AVCI G,Yücel B,erdiş e "The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients." , ss.242 - 249, 2020. 10.5505/tjo.2020.2240
ISNAD	GÜLER AVCI, GÜLHAN vd. "The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients". (2020), 242-249. https://doi.org/10.5505/tjo.2020.2240

APA	GÜLER AVCI G, Yücel B, erdiş e (2020). The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. Türk Onkoloji Dergisi, 35(3), 242 - 249. 10.5505/tjo.2020.2240
Chicago	GÜLER AVCI GÜLHAN,Yücel Birsen,erdiş eda The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. Türk Onkoloji Dergisi 35, no.3 (2020): 242 - 249. 10.5505/tjo.2020.2240
MLA	GÜLER AVCI GÜLHAN,Yücel Birsen,erdiş eda The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. Türk Onkoloji Dergisi, vol.35, no.3, 2020, ss.242 - 249. 10.5505/tjo.2020.2240
AMA	GÜLER AVCI G,Yücel B,erdiş e The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. Türk Onkoloji Dergisi. 2020; 35(3): 242 - 249. 10.5505/tjo.2020.2240
Vancouver	GÜLER AVCI G,Yücel B,erdiş e The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients. Türk Onkoloji Dergisi. 2020; 35(3): 242 - 249. 10.5505/tjo.2020.2240
IEEE	GÜLER AVCI G,Yücel B,erdiş e "The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients." Türk Onkoloji Dergisi, 35, ss.242 - 249, 2020. 10.5505/tjo.2020.2240
ISNAD	GÜLER AVCI, GÜLHAN vd. "The Effects of Radiotherapy on the Quality of Life in Localized Prostate Cancer Patients". Türk Onkoloji Dergisi 35/3 (2020), 242-249. https://doi.org/10.5505/tjo.2020.2240