Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease

Kokturk, Nurdan; Akkale, Tugba; Koç, Esra Meltem; nazik bahçecioğlu, sakine

doi:10.5578/tt.66351

Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease

Nurdan KÖKTÜRK, (Gazi Üniversitesi, Tıp Fakültesi, Göğüs Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Esra KOÇ, (İzmir Katip Çelebi Üniversitesi, Tıp Fakültesi, Aile Hekimliği Anabilim Dalı, İzmir, Türkiye)

Tuğba KÖRLÜ AKKALE, (Rize 82. Yıl Devlet Hastanesi, Göğüs Hastalıkları Kliniği, Rize, Türkiye)

Sakine BAHÇECİOĞLU (Ankara Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, Ankara, Türkiye)

Tüberküloz ve Toraks

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Yıl: 2020 Cilt: 68 Sayı: 1 Sayfa Aralığı: 25 - 34 Metin Dili: İngilizce DOI: 10.5578/tt.66351 İndeks Tarihi: 30-11-2020

Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease

Öz:

Introduction: Vitamin D deficiency and chronic obstructive pulmonary disease(COPD) are both world-wide health problems. Vitamin D has known to beimportant in infectious pathologies. However, there are conflicting results in therole of vitamin D in COPD exacerbation. This study was design to evaluate theprevalence of vitamin D deficiency among patients with COPD exacerbation inrelation with surrogate markers of exacerbation and long-term mortality in hospitalized patients with COPD.Materials and Methods: 117 hospitalized COPD patients were included between January 2010 to June 2013. Information was obtained through thepatients’ records and the electronic database of the hospital. The patients whohad on vitamin D and/or calcium therapy, and who were suspected of asthmawere excluded from the study.Results: The study included 117 patients and none of them were on vitaminD replacement on entry. The mean age was 67.95 ± 9.8 years. The number ofmale/female patients was 104/13. The mean forced expiratory volume in onesecond in percent predicted (FEV1%) was 39.97 ± 18.45. One hundred fifteen patients had vitamin D deficiency whereas only two patients had vitaminD ≥ 30 ng/dL. Seventy nine (69.5%) of the patients had severe vitamin Ddeficiency (< 10 ng/dL). The percentage of frequent exacerbators, patients who had microorganism growth and the median duration of hospital stay, mean FEV1 and survival did not differ between the groupof vitamin D < or ≥ 10 ng/dL. There was no meaningful correlation of vitamin D level and any of the surrogate markers of exacerbation.Conclusion: Severe vitamin D deficiency is heavily prevalent in Turkish COPD patients. However, it did not have an association onexacerbation and long term survival.

Anahtar Kelime:

Hastanede yatan kronik obstrüktif akciğer hastalığı olan hastalarda D vitamini durumu

Öz:

Giriş: Kronik obstrüktif akciğer hastalığı (KOAH)’nın ve D vitamini eksikliğinin her ikisi de dünya çapında sağlık sorunlarıdır. D vitamininin bulaşıcı patolojilerde önemli rolü olduğu bilinmektedir. Ayrıca, KOAH alevlenmesinde de D vitamininin rolü olduğu ile ilgili çelişkili sonuçlar vardır. Bu çalışma, KOAH›lı hastalarda vitamin D eksikliğinin yaygınlığını; hastanede yatan KOAH’lı hastaların alevlenme belirteçleri ve uzun dönem mortalite ile D vitamini arasındaki ilişkiyi değerlendirmek için tasarlandı. Materyal ve Metod: Ocak 2010-Haziran 2013 tarihleri arasında hastanede yatmış 117 KOAH hastası çalışmaya dahil edildi. Bilgilere hasta kayıtları ve hastanenin elektronik veri tabanı aracılığıyla ulaşıldı. D vitamini ve/veya kalsiyum tedavisi gören ve astım şüphesi alan hastalar çalışma dışı bırakıldı. Bulgular: Çalışmaya dahil edilen 117 hastanın hiçbiri D vitamini replasmanı almamaktaydı. Ortalama yaş 67.95 ± 9.8 yıl idi. Erkek/ kadın hasta sayısı 104/13’tü. Zorlu ekspirasyonun birinci saniyesinde atılan volüm (FEV1%) 39.97 ± 18.45 idi. Yüz on beş hastada D vitamini eksikliği vardı, sadece iki hastanın D vitamini ≥ 30 ng/dL idi. Hastaların 79 (%69.5)’unda ciddi D vitamini eksikliği (< 10 ng/dL) vardı. D vitamini 10 ng/dL’nin altında olan ve 10 ng/dL ve üzerinde olan gruplar arasında alevlenme sıklığı, mikroorganizma üremesi, ortalama hastanede kalma süresi, ortalama FEV1 ve sağkalım açısından farklılık saptanmadı. Vitamin D düzeyi ve alevlenmenin belirteçleri arasında anlamlı bir ilişki yoktu. Sonuç: Türkiye’de KOAH hastalarında ciddi D vitamini eksikliği oldukça yaygındır. Ancak, bunun alevlenme ve uzun süreli sağkalım ile bir ilişkisi yoktur.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Kokturk N, Koç E, Akkale T, nazik bahçecioğlu s (2020). Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. , 25 - 34. 10.5578/tt.66351
Chicago	Kokturk Nurdan,Koç Esra Meltem,Akkale Tugba,nazik bahçecioğlu sakine Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. (2020): 25 - 34. 10.5578/tt.66351
MLA	Kokturk Nurdan,Koç Esra Meltem,Akkale Tugba,nazik bahçecioğlu sakine Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. , 2020, ss.25 - 34. 10.5578/tt.66351
AMA	Kokturk N,Koç E,Akkale T,nazik bahçecioğlu s Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. . 2020; 25 - 34. 10.5578/tt.66351
Vancouver	Kokturk N,Koç E,Akkale T,nazik bahçecioğlu s Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. . 2020; 25 - 34. 10.5578/tt.66351
IEEE	Kokturk N,Koç E,Akkale T,nazik bahçecioğlu s "Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease." , ss.25 - 34, 2020. 10.5578/tt.66351
ISNAD	Kokturk, Nurdan vd. "Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease". (2020), 25-34. https://doi.org/10.5578/tt.66351

APA	Kokturk N, Koç E, Akkale T, nazik bahçecioğlu s (2020). Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. Tüberküloz ve Toraks, 68(1), 25 - 34. 10.5578/tt.66351
Chicago	Kokturk Nurdan,Koç Esra Meltem,Akkale Tugba,nazik bahçecioğlu sakine Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. Tüberküloz ve Toraks 68, no.1 (2020): 25 - 34. 10.5578/tt.66351
MLA	Kokturk Nurdan,Koç Esra Meltem,Akkale Tugba,nazik bahçecioğlu sakine Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. Tüberküloz ve Toraks, vol.68, no.1, 2020, ss.25 - 34. 10.5578/tt.66351
AMA	Kokturk N,Koç E,Akkale T,nazik bahçecioğlu s Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. Tüberküloz ve Toraks. 2020; 68(1): 25 - 34. 10.5578/tt.66351
Vancouver	Kokturk N,Koç E,Akkale T,nazik bahçecioğlu s Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease. Tüberküloz ve Toraks. 2020; 68(1): 25 - 34. 10.5578/tt.66351
IEEE	Kokturk N,Koç E,Akkale T,nazik bahçecioğlu s "Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease." Tüberküloz ve Toraks, 68, ss.25 - 34, 2020. 10.5578/tt.66351
ISNAD	Kokturk, Nurdan vd. "Vitamin D status in hospitalized patients with chronic obstructive pulmonary disease". Tüberküloz ve Toraks 68/1 (2020), 25-34. https://doi.org/10.5578/tt.66351