Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?
Yıl: 2020 Cilt: 27 Sayı: 6 Sayfa Aralığı: 1621 - 1625 Metin Dili: İngilizce DOI: 10.5455/annalsmedres.2019.04.314 İndeks Tarihi: 02-12-2020
Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?
Öz: Aim: To evaluate the effect of coexistent extracapsular extension and seminal vesicle invasion on biochemical reccurence freesurvival rates in patients who had undergone open radical retropubic prostatectomy.Material and Methods: The data of 307 patients with clinically localized prostate cancer who had undergone radical retropubicprostatectomy between January 2000 and May 2019 were evaluated retrospectively. According to extension of tumor on surgicalspecimens, patients were classified into five groups as; organ-confined disease, extracapsular extension, isolated seminal vesicleinvasion, extracapsular extension in addition to seminal vesicle invasion and lymph node involvement. Patient groups were analyzedcategorically with regard to biochemical reccurence free survival rates by using Kaplan Meier analysis, log-rank and chi-squaretests. The effect of pathological features of surgical specimens on biochemical reccurence was evaluated by using univariate andmultivariate Cox regression analysis.Results: There were statistically significant differences on biochemical reccurence free survival rates among the five groups, andpathological stage and biochemical reccurence rates increased correspondingly. Multivariate Cox regression analysis showed thatcoexistent extracapsular extension and seminal vesicle invasion, and lymph node involvement are the two significant factors thatnegatively effect the biochemical reccurence free survival rate.Conclusion: Coexistence of extracapsular extension and seminal vesicle invasion is a worse prognostic factor compared to theirisolated forms.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Houston KA, King J, Li J, et al. Trends in prostate cancer incidence rates and prevalence of prostatespecific antigen screening by socioeconomic status and regions in the US, 2004-2013. J Urol 2018;199: 676-82.
- 2. Boehm K, Leyh-Bannurah S-R, Rosenbaum C, et al. Impact of preoperative risk on metastatic progression and cancer-specific mortality in patients with adverse pathologyat radical prostatectomy. BJU Int 2017; 120:666-72.
- 3. Busch J, Stephan C, Herold A, et al. Long-term oncological and continence outcomes after laparoscopic radical prostatectomy: a single-centre experience. BJU Int 2012;110:985-90.
- 4. Berney DM, Wheeler TM, Grignon DJ, et al. International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes. Mod Pathol 2011;24:39- 47.
- 5. Bloom KD, Richie JP, Schultz D, et al. Invasion of seminal vesicles by adenocarcinoma of the prostate: PSA outcome determined by preoperative and postoperative factors. Urology 2004;63:333-6.
- 6. Ahove DA, Hoffman KE, Hu JC, et al. Which patients with undetectable PSA levels 5 years after radical prostatectomy are still at risk of recurrence?-- implications for a risk-adapted follow-up strategy. Urology 2010;76:1201-5.
- 7. Ohori M, Scardino PT, Lapin SL, et al. The mechanisms and prognostic significance of seminal vesicle involvement by prostate cancer. Am J Surg Pathol 1993;17:1252-61.
- 8. Wheeler TM. Anatomic considerations in carcinoma of the prostate. Urol Clin North Am 1989;16:623-34.
- 9. Han M, Partin AW, Pound CR, et al. Long term biochemical disease-free and cancer-specific survival following anatomic radical retropubic prostatectomy. The 15-year Johns Hopkins experience. Urol Clin North Am 2001;28:555-65.
- 10. Forgues A, Rozet F, Audenet F, et al. Oncologic outcomes after minimally invasive radical prostatectomy in patients with seminal vesicle invasion (pT3b) without adjuvant therapy. World J Urol 2014;32:519-24.
- 11. Roehl KA, Han M, Ramos CG, et al.Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients. Long term results. J Urol 2004;172:910-14.
- 12. Billis A, Teixeira DA, Stelini RF, et al. Seminal vesicle invasion in radical prostatectomies: which is the most common route of invasion? Int Urol Nephrol 2007;39:1097-102.
- 13. Villers AA, McNeal JE, Redwine EA, et al. Pathogenesis and biological significance of seminal vesicle invasion in prostatic adenocarcinoma. J Urol 1990;143:1183-7.
- 14. Kristiansen A, Drevin L, Delahunt B, et al. Prognostic significance and biopsy characteristics of prostate cancer with seminal vesicle invasion on radical prostatectomy: a nationwide population-based study. Pathology 2017;49:715-20.
- 15. Kristiansen A, Wiklund F, Wiklund P, Egevad L. Prognostic significance of patterns of seminal vesicle invasion in prostate cancer. Histopathology 2013;62: 1049-56.
| APA | Erbay G, ÖZDEN C, Gokkaya C, tagci s, Aktaş B, Bulut S, memis a, baykam m (2020). Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. , 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| Chicago | Erbay Güven,ÖZDEN CÜNEYT,Gokkaya Cevdet Serkan,tagci suleyman,Aktaş Binhan Kağan,Bulut Suleyman,memis ali,baykam mehmet murat Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. (2020): 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| MLA | Erbay Güven,ÖZDEN CÜNEYT,Gokkaya Cevdet Serkan,tagci suleyman,Aktaş Binhan Kağan,Bulut Suleyman,memis ali,baykam mehmet murat Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. , 2020, ss.1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| AMA | Erbay G,ÖZDEN C,Gokkaya C,tagci s,Aktaş B,Bulut S,memis a,baykam m Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. . 2020; 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| Vancouver | Erbay G,ÖZDEN C,Gokkaya C,tagci s,Aktaş B,Bulut S,memis a,baykam m Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. . 2020; 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| IEEE | Erbay G,ÖZDEN C,Gokkaya C,tagci s,Aktaş B,Bulut S,memis a,baykam m "Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?." , ss.1621 - 1625, 2020. 10.5455/annalsmedres.2019.04.314 |
| ISNAD | Erbay, Güven vd. "Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?". (2020), 1621-1625. https://doi.org/10.5455/annalsmedres.2019.04.314 |
| APA | Erbay G, ÖZDEN C, Gokkaya C, tagci s, Aktaş B, Bulut S, memis a, baykam m (2020). Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. Annals of Medical Research, 27(6), 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| Chicago | Erbay Güven,ÖZDEN CÜNEYT,Gokkaya Cevdet Serkan,tagci suleyman,Aktaş Binhan Kağan,Bulut Suleyman,memis ali,baykam mehmet murat Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. Annals of Medical Research 27, no.6 (2020): 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| MLA | Erbay Güven,ÖZDEN CÜNEYT,Gokkaya Cevdet Serkan,tagci suleyman,Aktaş Binhan Kağan,Bulut Suleyman,memis ali,baykam mehmet murat Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. Annals of Medical Research, vol.27, no.6, 2020, ss.1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| AMA | Erbay G,ÖZDEN C,Gokkaya C,tagci s,Aktaş B,Bulut S,memis a,baykam m Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. Annals of Medical Research. 2020; 27(6): 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| Vancouver | Erbay G,ÖZDEN C,Gokkaya C,tagci s,Aktaş B,Bulut S,memis a,baykam m Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?. Annals of Medical Research. 2020; 27(6): 1621 - 1625. 10.5455/annalsmedres.2019.04.314 |
| IEEE | Erbay G,ÖZDEN C,Gokkaya C,tagci s,Aktaş B,Bulut S,memis a,baykam m "Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?." Annals of Medical Research, 27, ss.1621 - 1625, 2020. 10.5455/annalsmedres.2019.04.314 |
| ISNAD | Erbay, Güven vd. "Is it important to see the coexistent seminal vesicle invasion and extracapsular extension at the radical prostatectomy specimen reports?". Annals of Medical Research 27/6 (2020), 1621-1625. https://doi.org/10.5455/annalsmedres.2019.04.314 |
