In Covid-19 epidemic, in USA, the public information requirement has increased the social media use level by citizens and the mass media, and the focus of the news production process is based on the federal government’s pandemic activities. The focus of this study is the argument that economic-political and ideological differences affect news channels’ presentation of the government’s work on the pandemic. The aim of the study is to reveal the effect of the political economy of the media on the information flow on Twitter during the Covid-19 crisis period and determine similarities and differences of CNN and Fox News channels. In this context, content with the highest level of interaction about government’s anti-epidemic activities, were analyzed with the critical discourse analysis method on the Twitter accounts of CNN and Fox News between March and April 2020. As a result of the analysis, it is found out that D. Trump and the Government’s Outbreak Management Performance was presented as “successful and positive” in Fox News, “unsuccessful and negative” in CNN and the discursive difference of the news is related to the ideological, economic and political structure of the mass media.