Aim: Previous studies have shown cyclodextrins bind to a variety of medications. The hypothesis in our study is to determine whetheror not sugammadex interacts with the lipophilic medication of ketamine to shorten the effect duration and ensure earlier recovery.Material and Methods: The study used 24 adult male Sprague-Dawley rats. Rats were randomly divided into 4 equal groups. Each ratwas administered 75 mg/kg ketamine intraperitoneal (ip) bolus and then in the fifth minute rats was administered sugammadex atappropriate doses for their group through the lateral vein in the tail. Group C (control group) were administered 15 mL/kg physiologicserum (PS) (n=6), Group Sgdx 16 were administered 16 mg/kg sugammadex (n=6), Group Sgdx 100 were administered 100 mg/kgsugammadex (n=6) and Group Sgdx 1000 were administered 1000 mg/kg sugammadex (n=6). The heart rate, respiratory rate andrecovery durations of the rats were recorded.Results: The recovery duration in the Sgdx 100 group was statistically significantly shorter compared to the control group (p=0.026),while the recovery duration in the Sgdx 1000 group was statistically significantly shorter than the control group (p<0.001) andthe Sgdx 16 group (p=0.015). Heart rate was statistically significantly low in the Sgdx 1000 group compared to the control group(p<0.05). Respiratory rates were similar.Conclusion: Our study showed that 100 mg/kg and 1000 mg/kg sugammadex doses significantly shortened recovery. We concludethat there is a need for more research about the interaction between ketamine and sugammadex.