Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus
Yıl: 2020 Cilt: 5 Sayı: 2 Sayfa Aralığı: 122 - 128 Metin Dili: İngilizce DOI: 10.14744/bej.2020.43434 İndeks Tarihi: 02-12-2020
Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus
Öz: Objectives: The aim of this study was to histopathologically compare patients with and without diabetes mellitus whounderwent pterygium excision.Methods: In this retrospective case-control study, 60 patients with a history of pterygium excision were divided into 2groups: those with DM and those without DM. Histopathological findings (squamous metaplasia, dysplasia, inflammation,fibrinoid changes, and vascularization) were compared.Results: The mean age of the 60 patients (females, 54.5%) included in the study was 58.6±12.8 years. The mean agewas 53.7±13.7 years in the patients with DM and 63.6±9.6 years in the patients without DM. There were no significantdifferences in the excised pterygium tissues in terms of squamous metaplasia, dysplasia, fibrinoid changes, inflammation,or vascularization.Conclusion: There was no histopathological difference in the pterygium tissue in patients with DM.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Kase S, Takahashi S, Sato I, Nakanishi K, Yoshida K, Ohno S. Expression of p27(KIP1) and cyclin D1, and cell proliferation in human pterygium. Br J Ophthalmol 2007;91:958–61.
- 2. Bradley JC, Yang W, Bradley RH, Reid TW, Schwab IR. The science of pterygia. Br J Ophthalmol 2010;94:815–20.
- 3. Chowers I, Pe'er J, Zamir E, Livni N, Ilsar M, Frucht-Pery J. Proliferative activity and p53 expression in primary and recurrent pterygia. Ophthalmology 2001;108:985–8.
- 4. Yang SF, Lin CY, Yang PY, Chao SC, Ye YZ, Hu DN. Increased expression of gelatinase (MMP-2 and MMP-9) in pterygia and pterygium fibroblasts with disease progression and activation of protein kinase C. Invest Ophthalmol Vis Sci 2009;50:4588–96.
- 5. Gharaee H, Shayegan MR, Khakzad MR, Kianoush S, VarastehAR, Sankian M, et al. The expression of vascular endothelial growth factor in pterygium tissue of atopic patients. Int Ophthalmol 2014;34:1175–81.
- 6. Alba-Loureiro TC, Munhoz CD, Martins JO, Cerchiaro GA, Scavone C, Curi R, et al. Neutrophil function and metabolism in individuals with diabetes mellitus. Braz J Med Biol Res 2007;40:1037–44.
- 7. Onitilo AA, Engel JM, Glurich I, Stankowski RV, Williams GM, Doi SA. Diabetes and cancer I: risk, survival, and implications for screening. Cancer Causes Control 2012;23:967–81.
- 8. Džunić B, Jovanović P, Veselinović D, Petrović A, Stefanović I, Kovačević I. Analysis of pathohistological characteristics of pterygium. Bosn J Basic Med Sci 2010;10:307–13.
- 9. Chui J, Coroneo MT, Tat LT, Crouch R, Wakefield D, Di Girolamo N. Ophthalmic pterygium: a stem cell disorder with premalignant features. Am J Pathol 2011;178:817–27.
- 10. Chui J, Di Girolamo N, Wakefield D, Coroneo MT. The pathogenesis of pterygium: current concepts and their therapeutic implications. Ocul Surf 2008;6:24–43.
- 11. Asokan R, Venkatasubbu RS, Velumuri L, Lingam V, George R. Prevalence and associated factors for pterygium and pinguecula in a South Indian population. Ophthalmic Physiol Opt 2012;32:39–44.
- 12. Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP. Diabetes mellitus and inflammation. Curr Diab Rep 2013;13:435–44. 13. Mimura T, Obata H, Usui T, Mori M, Yamagami S, Funatsu H, et al. Pinguecula and diabetes mellitus. Cornea 2012;31:264–8.
- 14. Kaji Y, Oshika T, Amano S, Okamoto F, Koito W, Horiuchi S. Immunohistochemical localization of advanced glycation end products in pinguecula. Graefes Arch Clin Exp Ophthalmol 2006;244:104–8.
- 15. Shera AS, Jawad F, Maqsood A, Jamal S, Azfar M, Ahmed U. Prevalence of chronic complications and associated factors in type 2 diabetes. J Pak Med Assoc 2004;54:54–9.
- 16. Nepp J, Abela C, Polzer I, Derbolav A, Wedrich A. Is there a correlation between the severity of diabetic retinopathy and keratoconjunctivitis sicca?. Cornea 2000;19:487–91.
- 17. Mimura T, Usui T, Yamagami S, Funatsu H, Noma H, Honda N, et al. Recent causes of subconjunctival hemorrhage. Ophthalmologica 2010;224:133–7.
- 18. Vinten-Johansen J, et al. Sequential patterns of chemokine- and chemokine receptor-synthesis following vessel Wall injury in porcine coronary arteries. Atherosclerosis. 2007;192:75–84
- 19. Chevalier RL, Forbes MS, Thornhill BA. Ureteral obstruction as a model of renal interstitial fibrosis and obstructive nephropathy. Kidney Int 2009; 75:1145–52.
- 20. Marcovich AL, Morad Y, Sandbank J, Huszar M, Rosner M, Pollack A, et al. Angiogenesis in pterygium: morphometric and immunohistochemical study. Curr Eye Res 2002;25:17–22.
- 21. Cheung AT, Ramanujam S, Greer DA, Kumagai LF, Aoki TT. Microvascular abnormalities in the bulbar conjunctiva of patients with type 2 diabetes mellitus. Endocr Pract 2001;7:358–63.
- 22. Dogru M, Katakami C, Inoue M. Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology 2001;108:586–92.
- 23. Seifart U, Strempel I. Trockenes Auge und Diabetes mellitus [The dry eye and diabetes mellitus]. Ophthalmologe 1994;91:235–9.
- 24. Goebbels M. Tear secretion and tear film function in insulin dependent diabetics. Br J Ophthalmol 2000;84:19–21.
- 25. Kaiserman I, Kaiserman N, Nakar S, Vinker S. Dry eye in diabetic patients. Am J Ophthalmol 2005;139:498–503.
- 26. Dogru M, Stern ME, Smith JA, Foulks GN, Lemp MA, Tsubota K. Changing trends in the definition and diagnosis of dry eyes. Am J Ophthalmol 2005;140:507–8.
- 27. Rahman A, Yahya K, Ahmed T, Sharif-Ul-Hasan K. Diagnostic value of tear films tests in type 2 diabetes. J Pak Med Assoc 2007;57:577–81.
- 28. Inoue K, Okugawa K, Amano S, Oshika T, Takamura E, Egami F, et al. Blinking and superficial punctate keratopathy in patients with diabetes mellitus. Eye (Lond) 2005;19:418–21.
- 29. Afonso AA, Sobrin L, Monroy DC, Selzer M, Lokeshwar B, Pflugfelder SC. Tear fluid gelatinase B activity correlates with IL-1alpha concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci 1999;40:2506–12.
- 30. Prabhasawat P, Tseng SC. Frequent association of delayed tear clearance in ocular irritation. Br J Ophthalmol 1998;82:666–75.
- 31. Di Pascuale MA, Espana EM, Kawakita T, Tseng SC. Clinical characteristics of conjunctivochalasis with or without aqueous tear deficiency. Br J Ophthalmol. 2004;88:388–92.
- 32. Kormanovski A, Parra F, Jarillo-Luna A, Lara-Padilla E, PachecoYépez J, Campos-Rodriguez R. Oxidant/antioxidant state in tissue of prymary and recurrent pterygium. BMC Ophthalmol 2014;14:149.
- 33. Jagadapillai R, Rane MJ, Lin X, Roberts AM, Hoyle GW, Cai L, et al. Diabetic Microvascular Disease and Pulmonary Fibrosis: The Contribution of Platelets and Systemic Inflammation. Int J Mol Sci 2016;17:1853.
- 34. Jarmuzek P, Wielgos M, Bomba-Opon D. Placental pathologic changes in gestational diabetes mellitus. Neuro Endocrinol Lett 2015;36:101–5.
- 35. Sun LL, Warrier S, Beckingsale P. Pterygium and Rate of Dysplasia in Surgical Specimens. J Clinic Experiment Ophthalmol 2011;2:166.
- 36. Ooi JL, Sharma NS, Papalkar D, Sharma S, Oakey M, Dawes P, et al. Ultraviolet fluorescence photography to detect early sun damage in the eyes of school-aged children. Am J Ophthalmol 2006;141:294–8.
- 37. Dushku N, John MK, Schultz GS, Reid TW. Pterygia pathogenesis: corneal invasion by matrix metalloproteinase expressing altered limbal epithelial basal cells. Arch Ophthalmol 2001;119:695–706.
- 38. Di Girolamo N, Kumar RK, Coroneo MT, Wakefield D. UVB-mediated induction of interleukin-6 and -8 in pterygia and cultured human pterygium epithelial cells. Invest Ophthalmol Vis Sci 2002;43:3430–7.
- 39. Kria L, Ohira A, Amemiya T. Immunohistochemical local¬ization of basic fibroblast growth factor, platelet derived growth factor, transforming growth factor beta and tumor necrosis factor - alpha in the pterygium. Acta Histochem 1996;98:195–201.
- 40. Jiao W, Zhou C, Wang T, Yang S, Bi H, Liu L, et al. Prevalence and risk factors for pterygium in rural older adults in Shandong Province of China: a cross-sectional study. Biomed Res Int 2014;2014:658648.
- 41. Luthra R, Nemesure BB, Wu SY, Xie SH, Leske MC; Barbados Eye Studies Group. Frequency and risk factors for pterygium in the Barbados Eye Study. Arch Ophthalmol 2001;119:1827–32.
- 42. Tan CS, Lim TH, Koh WP, Liew GC, Hoh ST, Tan CC, et al. Epidemiology of pterygium on a tropical island in the Riau Archipelago. Eye (Lond) 2006;20:908–12.
- 43. Detels R, Dhir SP. Pterygium: a geographical study. Arch Ophthalmol 1967;78:485–91.
APA | EROĞUL Ö, eryiğit eroğul l, Şen Korkmaz N, Celik F, DOĞAN M, Gobeka H (2020). Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. , 122 - 128. 10.14744/bej.2020.43434 |
Chicago | EROĞUL Özgür,eryiğit eroğul leyla,Şen Korkmaz Nilay,Celik Fatih,DOĞAN Mustafa,Gobeka Hamidu Hamisi Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. (2020): 122 - 128. 10.14744/bej.2020.43434 |
MLA | EROĞUL Özgür,eryiğit eroğul leyla,Şen Korkmaz Nilay,Celik Fatih,DOĞAN Mustafa,Gobeka Hamidu Hamisi Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. , 2020, ss.122 - 128. 10.14744/bej.2020.43434 |
AMA | EROĞUL Ö,eryiğit eroğul l,Şen Korkmaz N,Celik F,DOĞAN M,Gobeka H Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. . 2020; 122 - 128. 10.14744/bej.2020.43434 |
Vancouver | EROĞUL Ö,eryiğit eroğul l,Şen Korkmaz N,Celik F,DOĞAN M,Gobeka H Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. . 2020; 122 - 128. 10.14744/bej.2020.43434 |
IEEE | EROĞUL Ö,eryiğit eroğul l,Şen Korkmaz N,Celik F,DOĞAN M,Gobeka H "Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus." , ss.122 - 128, 2020. 10.14744/bej.2020.43434 |
ISNAD | EROĞUL, Özgür vd. "Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus". (2020), 122-128. https://doi.org/10.14744/bej.2020.43434 |
APA | EROĞUL Ö, eryiğit eroğul l, Şen Korkmaz N, Celik F, DOĞAN M, Gobeka H (2020). Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. BEYOGLU EYE JOURNAL, 5(2), 122 - 128. 10.14744/bej.2020.43434 |
Chicago | EROĞUL Özgür,eryiğit eroğul leyla,Şen Korkmaz Nilay,Celik Fatih,DOĞAN Mustafa,Gobeka Hamidu Hamisi Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. BEYOGLU EYE JOURNAL 5, no.2 (2020): 122 - 128. 10.14744/bej.2020.43434 |
MLA | EROĞUL Özgür,eryiğit eroğul leyla,Şen Korkmaz Nilay,Celik Fatih,DOĞAN Mustafa,Gobeka Hamidu Hamisi Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. BEYOGLU EYE JOURNAL, vol.5, no.2, 2020, ss.122 - 128. 10.14744/bej.2020.43434 |
AMA | EROĞUL Ö,eryiğit eroğul l,Şen Korkmaz N,Celik F,DOĞAN M,Gobeka H Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. BEYOGLU EYE JOURNAL. 2020; 5(2): 122 - 128. 10.14744/bej.2020.43434 |
Vancouver | EROĞUL Ö,eryiğit eroğul l,Şen Korkmaz N,Celik F,DOĞAN M,Gobeka H Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus. BEYOGLU EYE JOURNAL. 2020; 5(2): 122 - 128. 10.14744/bej.2020.43434 |
IEEE | EROĞUL Ö,eryiğit eroğul l,Şen Korkmaz N,Celik F,DOĞAN M,Gobeka H "Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus." BEYOGLU EYE JOURNAL, 5, ss.122 - 128, 2020. 10.14744/bej.2020.43434 |
ISNAD | EROĞUL, Özgür vd. "Histopathological Evaluation of Pterygium Patients with Type 2 Diabetes Mellitus". BEYOGLU EYE JOURNAL 5/2 (2020), 122-128. https://doi.org/10.14744/bej.2020.43434 |