Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents

Küçükgüzel, Ş.Güniz; CUMAOĞLU, Ahmet; BEKÇİ, Hatice; HAN, Muhammed İhsan

doi:10.12991/jrp.2018.98

Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents

Muhammed İhsan HAN, (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Hatice BEKÇİ, (Erciyes Üniversitesi, Eczacılık Fakültesi, Farmasötik Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Ahmet CUMAOĞLU, (Erciyes Üniversitesi, Eczacılık Fakültesi, Farmasötik Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Şükriye Güniz KÜÇÜKGÜZEL (Marmara Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)

Marmara Pharmaceutical Journal

8 0

Yıl: 2018 Cilt: 22 Sayı: 4 Sayfa Aralığı: 559 - 569 Metin Dili: İngilizce DOI: 10.12991/jrp.2018.98 İndeks Tarihi: 03-12-2020

Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents

Öz:

A novel series of new naproxen derivatives (S)-ethyl{[4-(4-fluorophenyl)-5-[(1-(6-methoxynaphtalen-2-yl)ethyl)]-4H-1,2,4-triazole-3-yl]sulphanyl}acetate (5), (S)-2-({5-[1-(6-methoxynaphtalen-1-yl)ethyl]-4-fluorophenyl-4H1,2,4-triazole-3-yl}sulphanyl)acetohydrazide (6), 2-{[5-[1-(6-methoxynaphtalen-2-yl)ethyl]-4-(4-fluorophenyl)-4H-1,2,4-triazole-3-yl]sulphanyl}-N'-[(substituted)methylidene]acetohydrazides (7a-m) were synthesized, in this study. Thestructures of compounds 5, 6 and 7a-m were defined by spectral (1H-NMR, 13C-NMR, HR-MS and FT-IR) methods andtheir purity was proven by elemental analysis, thin layer chromatography and high pressure liquid chromatography.These compounds were evaluated for in vitro anticancer activity by using MTS method against PC-3 and DU-143(androgen-independent human prostate cancer cell lines) and LNCaP (androgen-sensitive human prostateadenocarcinoma) prostate cancer cell lines. Cisplatin was used as the positive sensitivity reference standard. Compounds(7a-m) exhibited anticancer activity with IC50 values of 87.2-400 µM against prostate cancer cell lines.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	HAN M, BEKÇİ H, CUMAOĞLU A, Küçükgüzel Ş (2018). Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. , 559 - 569. 10.12991/jrp.2018.98
Chicago	HAN Muhammed İhsan,BEKÇİ Hatice,CUMAOĞLU Ahmet,Küçükgüzel Ş.Güniz Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. (2018): 559 - 569. 10.12991/jrp.2018.98
MLA	HAN Muhammed İhsan,BEKÇİ Hatice,CUMAOĞLU Ahmet,Küçükgüzel Ş.Güniz Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. , 2018, ss.559 - 569. 10.12991/jrp.2018.98
AMA	HAN M,BEKÇİ H,CUMAOĞLU A,Küçükgüzel Ş Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. . 2018; 559 - 569. 10.12991/jrp.2018.98
Vancouver	HAN M,BEKÇİ H,CUMAOĞLU A,Küçükgüzel Ş Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. . 2018; 559 - 569. 10.12991/jrp.2018.98
IEEE	HAN M,BEKÇİ H,CUMAOĞLU A,Küçükgüzel Ş "Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents." , ss.559 - 569, 2018. 10.12991/jrp.2018.98
ISNAD	HAN, Muhammed İhsan vd. "Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents". (2018), 559-569. https://doi.org/10.12991/jrp.2018.98

APA	HAN M, BEKÇİ H, CUMAOĞLU A, Küçükgüzel Ş (2018). Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. Marmara Pharmaceutical Journal, 22(4), 559 - 569. 10.12991/jrp.2018.98
Chicago	HAN Muhammed İhsan,BEKÇİ Hatice,CUMAOĞLU Ahmet,Küçükgüzel Ş.Güniz Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. Marmara Pharmaceutical Journal 22, no.4 (2018): 559 - 569. 10.12991/jrp.2018.98
MLA	HAN Muhammed İhsan,BEKÇİ Hatice,CUMAOĞLU Ahmet,Küçükgüzel Ş.Güniz Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. Marmara Pharmaceutical Journal, vol.22, no.4, 2018, ss.559 - 569. 10.12991/jrp.2018.98
AMA	HAN M,BEKÇİ H,CUMAOĞLU A,Küçükgüzel Ş Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. Marmara Pharmaceutical Journal. 2018; 22(4): 559 - 569. 10.12991/jrp.2018.98
Vancouver	HAN M,BEKÇİ H,CUMAOĞLU A,Küçükgüzel Ş Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents. Marmara Pharmaceutical Journal. 2018; 22(4): 559 - 569. 10.12991/jrp.2018.98
IEEE	HAN M,BEKÇİ H,CUMAOĞLU A,Küçükgüzel Ş "Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents." Marmara Pharmaceutical Journal, 22, ss.559 - 569, 2018. 10.12991/jrp.2018.98
ISNAD	HAN, Muhammed İhsan vd. "Synthesis and characterization of 1,2,4-triazole containing hydrazide-hydrazones derived from (S)-Naproxen as anticancer agents". Marmara Pharmaceutical Journal 22/4 (2018), 559-569. https://doi.org/10.12991/jrp.2018.98