Unclear Issues Regarding COVID-19

Yıl: 2020 Cilt: 52 Sayı: 2 Sayfa Aralığı: 191 - 196 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2020.20092 İndeks Tarihi: 03-12-2020

Unclear Issues Regarding COVID-19

Öz:
Scientists from all over the world have been intensively working to discover different aspects of Coronavirus disease 2019 (COVID-19) since the first cluster of cases was reported in China. Herein, we aimed to investigate unclear issues related to transmission and pathogenesis of disease as well as accuracy of diagnostic tests and treatment modalities. A literature search on PubMed, Ovid, and EMBASE databases was conducted, and articles pertinent to identified search terms were extracted. A snow-ball search strategy was followed in order to retrieve additional relevant articles. It was reported that viral spread may occur during the asymptomatic phase of infection, and viral load was suggested to be a useful marker to assess disease severity. In contrast to immune response against viral infections, cytotoxic T lymphocytes decline in SARS-CoV-2 infection, which can be partially explained by direct invasion of T lymphocytes or apoptosis activated by SARS-CoV-2. Dysregulation of the urokinase pathway, cleavage of the SARS-CoV-2 Spike protein by FXa and FIIa, and consumption coagulopathy were the proposed mechanisms of the coagulation dysfunction in COVID-19. False-negative rates of reverse transcriptase polymerase chain reaction varied between 3% and 41% across studies. The probability of the positive test was proposed to decrease with the number of days past from symptom onset. Safety issues related to infection spread limit the use of high flow nasal oxygen (HFNO) and continuous positive airway pressure (CPAP) in hypoxic patients. Further studies are required to elucidate the challenging issues, thus enhancing the management of COVID-19 patients.
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APA YÜKSEL A, Karadoğan D, Gunduz Gurkan C, Tokgoz Akyil F, TOREYIN N, marım f, Arikan H, Sismanlar Eyuboglu T, Emiralioglu N, Serifoglu I, Develi E, ÇELİK s, Sertçelik Ü, Ramasli Gursoy T, Elverisli M, Alkan A, Er B, Fırıncıoğluları A, Günaydın F, Özakıncı H, OZCELIK N, Esendagli D, Asena A, köse n, Erçelik M, Yildiz Gulhan P, YILDIZ E, Irmak I, Yılmaz Kara B, Gurz S, Karakaş F, Akgün M (2020). Unclear Issues Regarding COVID-19. , 191 - 196. 10.5152/eurasianjmed.2020.20092
Chicago YÜKSEL AYCAN,Karadoğan Dilek,Gunduz Gurkan Canan,Tokgoz Akyil Fatma,TOREYIN NUR,marım feride,Arikan Huseyin,Sismanlar Eyuboglu Tugba,Emiralioglu Nagehan,Serifoglu Irem,Develi Elif,ÇELİK selma,Sertçelik Ümran,Ramasli Gursoy Tugba,Elverisli Mehmet Fatih,Alkan Asli,Er Berrin,Fırıncıoğluları Ali,Günaydın Fatma Esra,Özakıncı Hilal,OZCELIK Neslihan,Esendagli Dorina,Asena Aydin,köse neslihan,Erçelik Merve,Yildiz Gulhan Pinar,YILDIZ Ethem,Irmak Ilim,Yılmaz Kara Bilge,Gurz Selcuk,Karakaş Fatma Gülsüm,Akgün Metin Unclear Issues Regarding COVID-19. (2020): 191 - 196. 10.5152/eurasianjmed.2020.20092
MLA YÜKSEL AYCAN,Karadoğan Dilek,Gunduz Gurkan Canan,Tokgoz Akyil Fatma,TOREYIN NUR,marım feride,Arikan Huseyin,Sismanlar Eyuboglu Tugba,Emiralioglu Nagehan,Serifoglu Irem,Develi Elif,ÇELİK selma,Sertçelik Ümran,Ramasli Gursoy Tugba,Elverisli Mehmet Fatih,Alkan Asli,Er Berrin,Fırıncıoğluları Ali,Günaydın Fatma Esra,Özakıncı Hilal,OZCELIK Neslihan,Esendagli Dorina,Asena Aydin,köse neslihan,Erçelik Merve,Yildiz Gulhan Pinar,YILDIZ Ethem,Irmak Ilim,Yılmaz Kara Bilge,Gurz Selcuk,Karakaş Fatma Gülsüm,Akgün Metin Unclear Issues Regarding COVID-19. , 2020, ss.191 - 196. 10.5152/eurasianjmed.2020.20092
AMA YÜKSEL A,Karadoğan D,Gunduz Gurkan C,Tokgoz Akyil F,TOREYIN N,marım f,Arikan H,Sismanlar Eyuboglu T,Emiralioglu N,Serifoglu I,Develi E,ÇELİK s,Sertçelik Ü,Ramasli Gursoy T,Elverisli M,Alkan A,Er B,Fırıncıoğluları A,Günaydın F,Özakıncı H,OZCELIK N,Esendagli D,Asena A,köse n,Erçelik M,Yildiz Gulhan P,YILDIZ E,Irmak I,Yılmaz Kara B,Gurz S,Karakaş F,Akgün M Unclear Issues Regarding COVID-19. . 2020; 191 - 196. 10.5152/eurasianjmed.2020.20092
Vancouver YÜKSEL A,Karadoğan D,Gunduz Gurkan C,Tokgoz Akyil F,TOREYIN N,marım f,Arikan H,Sismanlar Eyuboglu T,Emiralioglu N,Serifoglu I,Develi E,ÇELİK s,Sertçelik Ü,Ramasli Gursoy T,Elverisli M,Alkan A,Er B,Fırıncıoğluları A,Günaydın F,Özakıncı H,OZCELIK N,Esendagli D,Asena A,köse n,Erçelik M,Yildiz Gulhan P,YILDIZ E,Irmak I,Yılmaz Kara B,Gurz S,Karakaş F,Akgün M Unclear Issues Regarding COVID-19. . 2020; 191 - 196. 10.5152/eurasianjmed.2020.20092
IEEE YÜKSEL A,Karadoğan D,Gunduz Gurkan C,Tokgoz Akyil F,TOREYIN N,marım f,Arikan H,Sismanlar Eyuboglu T,Emiralioglu N,Serifoglu I,Develi E,ÇELİK s,Sertçelik Ü,Ramasli Gursoy T,Elverisli M,Alkan A,Er B,Fırıncıoğluları A,Günaydın F,Özakıncı H,OZCELIK N,Esendagli D,Asena A,köse n,Erçelik M,Yildiz Gulhan P,YILDIZ E,Irmak I,Yılmaz Kara B,Gurz S,Karakaş F,Akgün M "Unclear Issues Regarding COVID-19." , ss.191 - 196, 2020. 10.5152/eurasianjmed.2020.20092
ISNAD YÜKSEL, AYCAN vd. "Unclear Issues Regarding COVID-19". (2020), 191-196. https://doi.org/10.5152/eurasianjmed.2020.20092
APA YÜKSEL A, Karadoğan D, Gunduz Gurkan C, Tokgoz Akyil F, TOREYIN N, marım f, Arikan H, Sismanlar Eyuboglu T, Emiralioglu N, Serifoglu I, Develi E, ÇELİK s, Sertçelik Ü, Ramasli Gursoy T, Elverisli M, Alkan A, Er B, Fırıncıoğluları A, Günaydın F, Özakıncı H, OZCELIK N, Esendagli D, Asena A, köse n, Erçelik M, Yildiz Gulhan P, YILDIZ E, Irmak I, Yılmaz Kara B, Gurz S, Karakaş F, Akgün M (2020). Unclear Issues Regarding COVID-19. Eurasian Journal of Medicine, 52(2), 191 - 196. 10.5152/eurasianjmed.2020.20092
Chicago YÜKSEL AYCAN,Karadoğan Dilek,Gunduz Gurkan Canan,Tokgoz Akyil Fatma,TOREYIN NUR,marım feride,Arikan Huseyin,Sismanlar Eyuboglu Tugba,Emiralioglu Nagehan,Serifoglu Irem,Develi Elif,ÇELİK selma,Sertçelik Ümran,Ramasli Gursoy Tugba,Elverisli Mehmet Fatih,Alkan Asli,Er Berrin,Fırıncıoğluları Ali,Günaydın Fatma Esra,Özakıncı Hilal,OZCELIK Neslihan,Esendagli Dorina,Asena Aydin,köse neslihan,Erçelik Merve,Yildiz Gulhan Pinar,YILDIZ Ethem,Irmak Ilim,Yılmaz Kara Bilge,Gurz Selcuk,Karakaş Fatma Gülsüm,Akgün Metin Unclear Issues Regarding COVID-19. Eurasian Journal of Medicine 52, no.2 (2020): 191 - 196. 10.5152/eurasianjmed.2020.20092
MLA YÜKSEL AYCAN,Karadoğan Dilek,Gunduz Gurkan Canan,Tokgoz Akyil Fatma,TOREYIN NUR,marım feride,Arikan Huseyin,Sismanlar Eyuboglu Tugba,Emiralioglu Nagehan,Serifoglu Irem,Develi Elif,ÇELİK selma,Sertçelik Ümran,Ramasli Gursoy Tugba,Elverisli Mehmet Fatih,Alkan Asli,Er Berrin,Fırıncıoğluları Ali,Günaydın Fatma Esra,Özakıncı Hilal,OZCELIK Neslihan,Esendagli Dorina,Asena Aydin,köse neslihan,Erçelik Merve,Yildiz Gulhan Pinar,YILDIZ Ethem,Irmak Ilim,Yılmaz Kara Bilge,Gurz Selcuk,Karakaş Fatma Gülsüm,Akgün Metin Unclear Issues Regarding COVID-19. Eurasian Journal of Medicine, vol.52, no.2, 2020, ss.191 - 196. 10.5152/eurasianjmed.2020.20092
AMA YÜKSEL A,Karadoğan D,Gunduz Gurkan C,Tokgoz Akyil F,TOREYIN N,marım f,Arikan H,Sismanlar Eyuboglu T,Emiralioglu N,Serifoglu I,Develi E,ÇELİK s,Sertçelik Ü,Ramasli Gursoy T,Elverisli M,Alkan A,Er B,Fırıncıoğluları A,Günaydın F,Özakıncı H,OZCELIK N,Esendagli D,Asena A,köse n,Erçelik M,Yildiz Gulhan P,YILDIZ E,Irmak I,Yılmaz Kara B,Gurz S,Karakaş F,Akgün M Unclear Issues Regarding COVID-19. Eurasian Journal of Medicine. 2020; 52(2): 191 - 196. 10.5152/eurasianjmed.2020.20092
Vancouver YÜKSEL A,Karadoğan D,Gunduz Gurkan C,Tokgoz Akyil F,TOREYIN N,marım f,Arikan H,Sismanlar Eyuboglu T,Emiralioglu N,Serifoglu I,Develi E,ÇELİK s,Sertçelik Ü,Ramasli Gursoy T,Elverisli M,Alkan A,Er B,Fırıncıoğluları A,Günaydın F,Özakıncı H,OZCELIK N,Esendagli D,Asena A,köse n,Erçelik M,Yildiz Gulhan P,YILDIZ E,Irmak I,Yılmaz Kara B,Gurz S,Karakaş F,Akgün M Unclear Issues Regarding COVID-19. Eurasian Journal of Medicine. 2020; 52(2): 191 - 196. 10.5152/eurasianjmed.2020.20092
IEEE YÜKSEL A,Karadoğan D,Gunduz Gurkan C,Tokgoz Akyil F,TOREYIN N,marım f,Arikan H,Sismanlar Eyuboglu T,Emiralioglu N,Serifoglu I,Develi E,ÇELİK s,Sertçelik Ü,Ramasli Gursoy T,Elverisli M,Alkan A,Er B,Fırıncıoğluları A,Günaydın F,Özakıncı H,OZCELIK N,Esendagli D,Asena A,köse n,Erçelik M,Yildiz Gulhan P,YILDIZ E,Irmak I,Yılmaz Kara B,Gurz S,Karakaş F,Akgün M "Unclear Issues Regarding COVID-19." Eurasian Journal of Medicine, 52, ss.191 - 196, 2020. 10.5152/eurasianjmed.2020.20092
ISNAD YÜKSEL, AYCAN vd. "Unclear Issues Regarding COVID-19". Eurasian Journal of Medicine 52/2 (2020), 191-196. https://doi.org/10.5152/eurasianjmed.2020.20092