Relationship between liver histology and platelet parameters in patients with chronic hepatitis B
Yıl: 2019 Cilt: 44 Sayı: 4 Sayfa Aralığı: 1160 - 1166 Metin Dili: İngilizce DOI: 10.17826/cumj.512080 İndeks Tarihi: 04-12-2020
Relationship between liver histology and platelet parameters in patients with chronic hepatitis B
Öz: Purpose: Many noninvasive tests have been studied forthe diagnosis and determining the liver fibrosis score. Inthis study, we aimed to research the correlation of plateletparameters and stage of liver fibrosis in patients withchronic hepatitis B (CHB).Materials and Methods: A total of 140 biopsy-provennaive CHB cases were included in the study. HBV-DNAlevel, liver enzymes and function tests, white blood cellcount, platelet parametres, hemoglobin, histologicalactivity index (HAI) and other routine biochemicalparameters were tested. Patients were divided into twogroups as F0-2 and F3-6 with Ishak scoring systemaccording to the severity of liver fibrosis.Results: There was no significant difference between thegroups F0-2 and F3-6 in terms of, platelet (PLT), meanplatelet volume (MPV), platelet distribution width (PDW)and plateletcrit (PCT). There was a significant differencebetween these two groups for HAI, aspartateaminotransferase (AST), gamma glutamyl transpeptidase(GGT), age and lymphocyte (LYM) parameters. Theformulation of (AST x Age x LYM) / √PLT)which wasformed from many different combinations, wasinvestigated in order to be used in predicting the liverfibrosis stage.Conclusion: Although our new index is moresensitivitythan other noninvasive scoring systems, it isneeded to have a larger sample size in patients with severestage liver fibrosis in order to be used safely as anoninvasive marker.
Anahtar Kelime: Kronik hepatit B hastalarında karaciğer histolojisi ile platelet parametreleri arasındaki ilişki
Öz: Amaç: Karaciğer fibrozis tanı ve skorunun belirlenmesi için birçok noninvaziv test çalışılmıştır. Bu çalışmada, kronik hepatit B (KHB) olan hastalarda platelet parametrelerinin ve karaciğer fibrozisin evresi arasındaki ilişkiyi araştırmayı amaçladık. Gereç ve Yöntem: Çalışmaya toplam 140 biyopsi ile kanıtlanmış naiv KHB olgusu dahiledildi. HBV-DNA düzeyi, karaciğer enzimleri ve fonksiyon testleri, beyaz kan hücresi sayısı, platelet parametreleri, hemoglobin, histolojik aktivite indeksi (HAI) ve diğer rutin biyokimyasal parametreler test edildi. Karaciğer biyopsi örnekleri modifiye Ishak skorlama sistemi kullanılarak incelendi. Hastalar karaciğer fibrosis şiddetine göre modifiye İshak puanlama sistemi ile F0-2 ve F3-6 olarak iki gruba ayrıldı. Bulgular: F0-2 ve F3-6 grupları arasında platelet (PLT), ortalama platelet hacmi (MPV), platelet dağılım genişliği (PDW) ve platelecrit (PCT) açısından anlamlı fark yoktu. Bu iki grup arasında HAİ, aspartat transaminaz (AST), gama glutamil transaminaz (GGT), yaş ve lenfosit parametreleri açısından anlamlı fark vardı. Karaciğer fibrozis evresini tahmin etmede kullanılmak üzere birçok farklı kombinasyondan oluşan (AST x Yaş x Lenfosit) /√PLT) formülasyonu araştırıldı. Sonuç: Yeni indeksimiz diğer noninvaziv skorlama sistemlerine göre daha sensitivitesi yüksek olmakla birlikte noninvaziv belirteç olarak güvenle kullanılabilmesi için ileri karaciğer fibrozis düzeyine sahip olan hastaların daha fazla olduğu, daha geniş örneklem büyüklüğüne sahip çalışmalara ihtiyaç vardır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Ceylan B, Mete B, Fincanci M, Aslan T, Akkoyunlu Y, Ozguneş N et al. A new model using platelet indices to predict liver fibrosis in patients with chronichepatitis B infection. Wien Klin Wochenschr. 2013;125:453-60.
- 2. Zeremski M, Dimova RB, Benjamin S, Makeyeva J, Yantiss RK, Gambarin-Gelwan M et al. FibroSURE as a noninvasive marker of liver fibrosis and inflammation in chronic hepatitis B. BMC Gastroenterol. 2014;14:118.
- 3. Koda M, Matunaga Y, Kawakami M, Kishimoto Y, Suou T, Murawaki Y. FibroIndex, a practical index for predicting significant fibrosis in patients with chronic hepatitis C. Hepatology. 2007;45:297-306.
- 4. Rossi E, Adams L, Prins A, Bulsara M, de Boer B, Garas G et al. Validation of the fibrotest biochemical markers score in assessing liver fibrosis in hepatitis C patients. Clin Chem. 2003;49:450-4.
- 5. Adams LA, Bulsara M, Rossi E, DeBoer B, Speers D, George J et al. Hepascore: An accurate validated predictor of liver fibrosis in chronic hepatitis C infection. Clin Chem. 2005;51:1867-73.
- 6. Wai CT, Greenson JK, Fontana RJ, Kalbfleisch JD, Marrero JA, Conjeevaram HS et al. A simple noninvasive index can predict both significant fibrosis and cirrhosis in patients with chronic hepatitis C. Hepatology. 2003;38:518-26.
- 7. Hernaez R, Yeh HC, Lazo M, Chung HM, Hamilton J, Koteish A et al. Elevated ALT and GGT predict allcause mortality and hepatocellular carcinoma in Taiwanese male: a case-cohort study. Hepatol Int. 2013;7:1040-9.
- 8. Yin Z and Chen Y. Prognostic value of Gcglobulin in Chinese patients with acute-on-chronic hepatitis B liver failure. J Coll Physicians Surg Pak. 2015;25:176- 80.
- 9. Lai CL, Ratziu V, Yuen MF, Poynard T. Viral hepatitis B. Lancet. 2003;362:2089-94.
- 10. de Franchis R, Hadengue A, Lau G, Lavanchy D, Lok A, Mcintyre N et al. EASL International Consensus Conference on Hepatitis B. 13–14 September, 2002 Geneva, Switzerland. Consensus statement (long version). J Hepatol. 2003;39:S3-25.
- 11. Cadranel JF, Rufat P, Degos F. Practices of liver biopsy in France: Results of a prospective nationwide survey for the group of epidemiology of the French association for the study of the liver (AFEF). Hepatology. 2000;32:477-81.
- 12. Liaw YF, Leung N, Kao JH, Piratvisuth T, Gane E, Han KH et al. Chronic Hepatitis B Guideline Working Party of the Asian-Pacific Association for the Study of the Liver. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int. 2008;2:263-83.
- 13. Lee HH, Seo YS, Um SH, Won NH, Yoo H, Jung ES et al. Usefulness of non-invasive markers for predicting significant fibrosis in patients with chronic liver disease. J Korean Med Sci. 2010;25:67-74.
- 14. Sterling RK, Lissen E, Clumeck N, Sola R, Correa MC, Montaner J et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43:1317-25.
- 15. Purnak T, Olmez S, Torun S,Efe C, Sayilir A, Ozaslan E et al. Mean platelet volume is increased in chronic hepatitis C patients with advanced fibrosis. Clin Res Hepatol Gastroenterol. 2013;37:41-46.
- 16. Ekiz F, Yüksel O, Koçak E,Yilmaz B, Altınbaş A, Çoban S et al. Mean platelet volume as a fibrosis marker in patients with chronic hepatitis B. J Clin Lab Anal. 2011;25:162-5.
- 17. Hakyemez IN, Bolukcu S, Durdu B, Aslan T. Red cell volume distribution width to platelet ratio is an important predictor of liver fibrosis and cirrhosis in chronic hepatitis B. Viral Hepatit Dergisi. 2016;22:52- 7.
- 18. Kim EY, Lee JW, Yoo HM, Park CH, Song KY. The platelet-to-lymphocyte ratio versus neutrophil-tolymphocyte ratio: Which is better as a prognostic factor in gastric cancer? Ann Surg Oncol. 2015;22:4363-70.
- 19. Choi WJ, Cleghorn MC, Jiang H, Jackson TD, Okrainec A, Quereshy FA. Preoperative neutrophilto-lymphocyte ratio is a better prognostic serum biomarker than platelet-to-lymphocyte ratio in patients undergoing resection for nonmetastatic colorectal cancer. Ann Surg Oncol. 2015;22:S603-13.
- 20. Peng W, Li C, Zhu WJ, Wen TF, Yan LN, Li B et al. Prognostic value of the platelet to lymphocyte ratio change in liver cancer. J Surg Res. 2015;194:464-70.
- 21. Li X, Chen ZH, Xing YF, Wang TT, Wu DH, Wen JY et al. Platelet-to-lymphocyte ratio acts as a prognostic factor for patients with advanced hepatocellular carcinoma. Tumor Biol. 2015;36:2263-9.
- 22. Meng X, Wei G, Chang Q, Peng R, Shi G, Zheng P et al. The platelet-to-lymphocyte ratio, superior to the neutrophil-to-lymphocyte ratio, correlates with hepatitis C virus infection. Int J Infect Dis. 2016;45:72-7.
| APA | Cosgun C, karabulut a, Yilmaz B, Köseoğlu H, Demir E (2019). Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. , 1160 - 1166. 10.17826/cumj.512080 |
| Chicago | Cosgun Cihat,karabulut alpaslan,Yilmaz Baris,Köseoğlu Hüseyin,Demir Emre Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. (2019): 1160 - 1166. 10.17826/cumj.512080 |
| MLA | Cosgun Cihat,karabulut alpaslan,Yilmaz Baris,Köseoğlu Hüseyin,Demir Emre Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. , 2019, ss.1160 - 1166. 10.17826/cumj.512080 |
| AMA | Cosgun C,karabulut a,Yilmaz B,Köseoğlu H,Demir E Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. . 2019; 1160 - 1166. 10.17826/cumj.512080 |
| Vancouver | Cosgun C,karabulut a,Yilmaz B,Köseoğlu H,Demir E Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. . 2019; 1160 - 1166. 10.17826/cumj.512080 |
| IEEE | Cosgun C,karabulut a,Yilmaz B,Köseoğlu H,Demir E "Relationship between liver histology and platelet parameters in patients with chronic hepatitis B." , ss.1160 - 1166, 2019. 10.17826/cumj.512080 |
| ISNAD | Cosgun, Cihat vd. "Relationship between liver histology and platelet parameters in patients with chronic hepatitis B". (2019), 1160-1166. https://doi.org/10.17826/cumj.512080 |
| APA | Cosgun C, karabulut a, Yilmaz B, Köseoğlu H, Demir E (2019). Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. Cukurova Medical Journal, 44(4), 1160 - 1166. 10.17826/cumj.512080 |
| Chicago | Cosgun Cihat,karabulut alpaslan,Yilmaz Baris,Köseoğlu Hüseyin,Demir Emre Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. Cukurova Medical Journal 44, no.4 (2019): 1160 - 1166. 10.17826/cumj.512080 |
| MLA | Cosgun Cihat,karabulut alpaslan,Yilmaz Baris,Köseoğlu Hüseyin,Demir Emre Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. Cukurova Medical Journal, vol.44, no.4, 2019, ss.1160 - 1166. 10.17826/cumj.512080 |
| AMA | Cosgun C,karabulut a,Yilmaz B,Köseoğlu H,Demir E Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. Cukurova Medical Journal. 2019; 44(4): 1160 - 1166. 10.17826/cumj.512080 |
| Vancouver | Cosgun C,karabulut a,Yilmaz B,Köseoğlu H,Demir E Relationship between liver histology and platelet parameters in patients with chronic hepatitis B. Cukurova Medical Journal. 2019; 44(4): 1160 - 1166. 10.17826/cumj.512080 |
| IEEE | Cosgun C,karabulut a,Yilmaz B,Köseoğlu H,Demir E "Relationship between liver histology and platelet parameters in patients with chronic hepatitis B." Cukurova Medical Journal, 44, ss.1160 - 1166, 2019. 10.17826/cumj.512080 |
| ISNAD | Cosgun, Cihat vd. "Relationship between liver histology and platelet parameters in patients with chronic hepatitis B". Cukurova Medical Journal 44/4 (2019), 1160-1166. https://doi.org/10.17826/cumj.512080 |
