Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 1 - 9 Metin Dili: Türkçe DOI: 10.5222/GKDAD.2020.86547 İndeks Tarihi: 07-12-2020

Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması

Öz:
Amaç: Kardiyopulmoner baypas (KPB) sonrası oluşan akut böbrek hasarı (ABH) sık görülmekte ve bu durumerken ve geç postoperatif sonuçlar üzerinde ciddi etkiler oluşturmaktadır. Bu retrospektif çalışmanın birincilamacı KPB eşliğinde kardiyovasküler cerrahi geçiren ve böbrek fonksiyonları normal olan hastalarda RIFLE,KDIGO ve AKIN sınıflamaları aracılığı ile cerrahi sonrası akut böbrek hasarı sıklığının saptanması ve akut böbrekhasarı gelişiminde rol alan risk faktörlerinin belirlenmesidir. Sekonder amacı ise bu 3 sınıflamanın ve risk faktörlerininerken mortalite ile ilintisini saptamaktır.Yöntem: Manisa Celal Bayar Üniversitesi Tıp Fakültesi Kalp Damar Cerrahisi Kliniğinde 2011-2015 tarihleriarasında KPB eşliğinde kardiyovasküler cerrahi geçiren ve sonrasında Kalp Damar Cerrahisi Yoğun Bakımdaizlenen hastaların dosyaları retrospektif olarak incelenerek 353 hasta çalışmaya dâhil edildi. Araştırmaya dâhiledilen her hastanın ameliyat öncesi demografik bilgileri, operasyon tipi, hemoglobin, hemotokrit düzeyleri,kreatinin değerleri kaydedildi. Postoperatif dönemde serum kreatinin değeri ve idrar çıkış miktarı kullanılarakgünlük olarak RIFLE, KDIGO ve AKIN skoru belirlendi. Verilerin değerlendirilmesinde ROC analizi ve logistikregresyon analizi kullanıldı.Bulgular: Araştırma grubumuzda KDIGO ve AKIN sınıflamalarına göre %28.6’sının RIFLE sınıflamasına göre ise%29.4’ünün herhangi bir ABH evresinde olduğu bulundu. Çalışmamızda, RİFLE, AKIN ve KDIGO sınıflamalarınagöre böbrek yetmezliği gelişimi ile ileri yaş, CABG ve kapak cerrahisinin birlikte yapılması, uzun pompa süresi,düşük preoperatif hemoglobin düzeyi, yüksek bazal kreatinin değeri, yüksek peroperatif kan transfüzyonu, uzunsüre yoğun bakımda kalış arasında anlamlı ilişki olduğu gösterildi. Çalışmamızda, hastane mortalitesinin tahminindeROC eğrisi altındaki alan RIFLE, AKIN ve KDIGO sınıflamaları için sırasıyla benzer şekilde 0.956, 0.957,0.956 olarak anlamlı bulun.Sonuç: Çalışmamızda, RIFLE, AKIN ve KDIGO sınıflamaları arasında mortalite tahmininde anlamlı bir fark bulunamamıştır.
Anahtar Kelime:

Comparison of RIFLE, AKIN and KDIGO Classifications in Patients with Cardiac Surgery

Öz:
Objective: Acute Kidney Injury (AKI) occurring after cardiac surgery is commonly seen and has serious effects on early and late postoperative outcomes. The primary objective of this retrospective study was to determine the incidence of acute renal injury using RIFLE, KDIGO and AKIN classifications in patients with normal renal function and to determine the risk factors involved in the development of acute renal injury. The secondary aim was to determine the relationship between these three classifications and risk factors with early mortality. Method: Patients who had undergone cardiovascular surgery with the aid of CPB between 2011 and 2015 at Manisa Celal Bayar University Medical Faculty Cardiovascular Surgery Clinic were examined retrospectively and 353 patients were included in the study. Preoperative demographic information, operation type, hemoglobin, hematocrit levels, and creatinine values of each patient were recorded. RIFLE, KDIGO and AKIN scores were determined daily using serum creatinine values and urine outputs in the postoperative period. ROC analysis and logistic regression analysis were used in the evaluation of the data. Results: According to the KDIGO, AKIN classifications, 28.6%, and RIFLE classifications, 29.4% of the research group were found to be in any AKI stage, respectıvely. According to RIFLE, AKIN and KDIGO classifications in our study, there was a significant relationship between the development of renal injury with advanced age, combined CABG-valve surgery, longer pump duration, low preoperative hemoglobin level, high baseline creatinine value, high perioperative blood transfusion and long- term intensive care unit stay. The area under the receiver operating characteristic curve for hospital mortality was similarly found to be 0.956, 0.957, 0.956 for the RIFLE, AKIN and KDIGO classifications, respectively. Conclusion: In our study, there was no significant difference in mortality estimation among RIFLE, AKIN and KDIGO classifications.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Thakar CV, Worley S, Arrigain S, Yared JP, Paganini EP. Influence of renal dysfunction on mortality after cardiac surgery: Modifying effect of preoperative renal function. Kidney Int. 2005;67(3):1112-9. https://doi.org/10.1111/j.1523-1755.2005.00177.x
  • 2. Kumar AB, Suneja M, Bayman EO, Weide GD, Tarasi M. Association between postoperative acute kidney injury and duration of cardiopulmonary bypass: A metaanalysis. J Cardiothorac Vasc Anesth [Internet]. 2012;26(1):64-9. Available from: http://dx.doi. org/10.1053/j.jvca.2011.07.007
  • 3. Kumar AB, Suneja M. Cardiopulmonary Bypass - associated acute kidney injury. Anesthesiology. 2011; 114(4):964-70. https://doi.org/10.1097/ALN.0b013e318210f86a
  • 4. Bellomo R, Ronco C, Kellum JA, Mehta RL, Palevsky P, Acute Dialysis Quality Initiative workgroup. Acute renal failure - definition, outcome measures, animal models, fluid therapy and information technology needs: the Second International Consensus Conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care [Internet]. 2004;8(4):R204-12. https://doi.org/10.1186/cc2872
  • 5. Mehta RL, Kellum JA, Shah S V., Molitoris BA, Ronco C, Warnock DG, et al. Acute kidney injury network: Report of an initiative to improve outcomes in acute kidney injury. Crit Care. 2007;11(2):1-8. https://doi.org/10.1186/cc5713
  • 6. Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO Clinical Practice Guideline for Acute Kidney Injury. Kidney inter., Suppl. 2012;2:1-138.
  • 7. Neves M, Fidalgo P, Gonçalves C, Leitão S, Santos RM, Carvalho A, et al. Acute kidney injury in an internal medicine ward in a Portuguese quaternary hospital. Eur J Intern Med [Internet]. 2014;25(2):169-72. Available from: http://dx.doi.org/10.1016/j.ejim.2013.09.007
  • 8. Sampaio MC, Máximo CAG, Montenegro CM, Mota DM, Fernandes TR, Bianco ACM, et al. Comparison of Diagnostic Criteria for Acute Kidney Injury in Cardiac Surgery. Arq Bras Cardiol. 2013;18-25. https://doi.org/10.5935/abc.20130115
  • 9. Bastin AJ, Ostermann M, Slack AJ, Diller GP, Finney SJ, Evans TW. Acute kidney injury after cardiac surgery according to Risk/Injury/Failure/Loss/End-stage, Acute Kidney Injury Network, and Kidney Disease: Improving Global Outcomes classifications. J Crit Care [Internet]. 2013;28(4):389-96. Available from: http://dx.doi. org/10.1016/j.jcrc.2012.12.008
  • 10. Haase M, Bellomo R, Matalanis G, Calzavacca P, Dragun D, Haase-Fielitz A. A comparison of the RIFLE and Acute Kidney Injury Network classifications for cardiac surgery-associated acute kidney injury: A prospective cohort study. J Thorac Cardiovasc Surg [Internet]. 2009;138(6):1370-6. Available from: http://dx.doi. org/10.1016/j.jtcvs.2009.07.007
  • 11. Robert AM, Kramer RS, Dacey LJ, Charlesworth DC, Leavitt BJ, Helm RE, et al. Cardiac surgery-associated acute kidney injury: A comparison of two consensus criteria. Ann Thorac Surg. [Internet]. 2010;90(6):1939- 43. Available from: http://dx.doi.org/10.1016/j. athoracsur.2010.08.018
  • 12. Enger TB, Pleym H, Stenseth R, Greiff G, Wahba A, Videm V. A Preoperative multimarker approach to evaluate acute kidney injury after cardiac surgery. J Cardiothorac Vasc Anesth. [Internet]. 2017;31(3):837- 46. Available from: http://dx.doi.org/10.1053/j. jvca.2016.10.005
  • 13. Park SK, Hur M, Kim E, Kim WH, Park JB, Kim Y, et al. Risk factors for acute kidney injury after congenital cardiac surgery in infants and children: A retrospective observational study. PLoS One. 2016;11(11):1-15. https://doi.org/10.1371/journal.pone.0166328
  • 14. Loef BG, Epema AH, Smilde TD, Henning RH, Ebels T, Navis G, et al. Immediate Postoperative Renal Function Deterioration in Cardiac Surgical Patients Predicts In-Hospital Mortality and Long-Term Survival. J Am Soc Nephrol. 2005;16(1):195-200. https://doi.org/10.1681/ASN.2003100875
  • 15. Duminda N. W, Keyvan K, W.Scott B, Vivek R, Joan I. Improving the identification of patients at risk of postoperative renal failure after cardiac surgery. Anesthesiology [Internet]. 2006;104(1):65-72. Available from: http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE =reference&D=emed7&NEWS=N&AN=2006195995 https://doi.org/10.1097/00000542-200601000-00012
  • 16. Hobson CE, Yavas S, Segal MS, Schold JD, Tribble CG, Layon AJ, et al. Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery. Circulation. 2009;119(18):2444-53. https://doi.org/10.1161/CIRCULATIONAHA.108.800011
  • 17. Kim WH, Park MH, Kim H-J, Lim H-Y, Shim HS, Sohn J-T, et al. Potentially Modifiable Risk Factors For Acute Kidney Injury After Surgery on The Thoracic Aorta. Medicine (Baltimore). 2015;94(2):e273. https://doi.org/10.1097/MD.0000000000000273
  • 18. Erdost HA, Ozkardesler S, Akan M, Iyilikci L, Unek T, Ocmen E, et al. Comparison of the RIFLE, AKIN, and KDIGO Diagnostic Classifications for Acute Renal Injury in Patients Undergoing Liver Transplantation. Transplant Proc [Internet]. 2016;48(6):2112-8. Available from: http://dx.doi.org/10.1016/j.transproceed.2016.03.044
  • 19. Karkouti K, Wijeysundera DN, Yau TM, Callum JL, Cheng DC, Crowther M, et al. Acute kidney injury after cardiac surgery. Focus on modifiable risk factors. Circulation. 2009;119(4):495-502. https://doi.org/10.1161/CIRCULATIONAHA.108.786913
  • 20. Karkouti K, Wijeysundera DN, Yau TM, McCluskey SA, Chan CT, Wong P, et al. Advance Targeted Transfusion in Anemic Cardiac Surgical Patients for Kidney Protection. Anesthesiology. 2012;116(3):613-21. https://doi.org/10.1097/ALN.0b013e3182475e39
  • 21. Koch CG, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, Blackstone EH. Duration of red-cell storage and complications after cardiac surgery. N Engl J Med. 2008;358:1229-39. https://doi.org/10.1056/NEJMoa070403
  • 22. Freeland K, Hamidian Jahromi A, Duvall LM, Mancini MC. Postoperative blood transfusion is an independent predictor of acute kidney injury in cardiac surgery patients. J Nephropathol. 2015; 4(4):121-6. https://doi: 10.12860/ jnp.2015.23
  • 23. Almac E, Ince C. The impact of storage on red cell function in blood transfusion. Best Pract Res Clin Anaesthesiol. 2007;21:195-208. https://doi.org/10.1016/j.bpa.2007.01.004
  • 24. Tinmouth A, Fergusson D, Yee IC, Hebert PC. Clinical consequences of red cell storage in the critically ill. Transfusion. 2006;46:2014-27. https://doi.org/10.1111/j.1537-2995.2006.01026.x
  • 25. Hoste EAJ, Clermont G, Kersten A, Venkataraman R, Angus DC, Bacquer D De, et al. RIFLE criteria for acute kidney injury are associated with hospital mortality in critically ill patients: a cohort analysis. Crit Care. 2006;10(3):1-10. https://doi.org/10.1186/cc4915
  • 26. Pistolesi V, Napoli A Di, Fiaccodori E, Zeppilli L, Polistena F, Sacco MI, et al. Severe acute kidney injury following cardiac surgery: short-term outcomes in patients undergoing continuous renal replacement therapy (CRRT). J Nephrol. 2016;29(2):229-39. https://doi.org/10.1007/s40620-015-0213-1
  • 27. Englberger L, Suri RM, Li Z, Casey ET, Daly RC, Dearani JA, et al. Clinical accuracy of RIFLE and Acute Kidney Injury Network ( AKIN ) criteria for acute kidney injury in patients undergoing cardiac surgery. Crit Care [Internet]. 2011;15(1):R16. https://doi.org/10.1186/cc9960
  • 28. Bagshaw SM, George C, Bellomo R. A comparison of the RIFLE and AKIN criteria for acute kidney injury in critically ill patients. Nephrol Dial Transpl. 2008; 23(February):1569-74. https://doi.org/10.1093/ndt/gfn009
  • 29. Joannidis M, Metniz B, Bauer P, Schusterschitz N, Moreno R. Acute kidney injury in critically ill patients classified by AKIN versus RIFLE using the SAPS 3 database. Intensive Care Med. 2009;35:1692-702. https://doi.org/10.1007/s00134-009-1530-4
  • 30. Yan X, Jia S, Meng X, Dong P, Jia M, Wan J, et al. Acute kidney injury in adult postcardiotomy patients with extracorporeal membrane oxygenation: evaluation of the RIFLE classification and the Acute Kidney Injury Network criteria. Eur J Cardio-thoracic Surg. 2010;37(2):334-8. https://doi.org/10.1016/j.ejcts.2009.07.004
  • 31. Lassnigg A, Schmid ER, Hiesmayr M, Falk C, Druml W, Bauer P, et al. Impact of minimal increases in serum creatinine on outcome in patients after cardiothoracic surgery: Do we have to revise current definitions of acute renal failure? Crit Care Med. 2008;36(4):1129- 37. https://doi.org/10.1097/CCM.0b013e318169181a
  • 32. Grieshaber P, Möller S, Arneth B, Roth P, Niemann B, Renz H, et al. Predicting Cardiac Surgery-Associated Acute Kidney Injury Using a Combination of Clinical Risk Scores and Urinary Biomarkers. Thorac Cardiovasc Surg. 2019; Feb 11. https://doi.org/10.1055/s-0039-1678565
  • 33. Wu MZ, Chen Y, Au WK, Chan D, Sit KY, Ho KL, et al. Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria. J Cardiol. 2018 Sep;72(3):247-254. Epub 2018 Mar 26. https://doi.org/10.1016/j.jjcc.2018.01.018
  • 34. Pickering JW, James MT, Palmer SC. Acute kidney injury and prognosis after cardiopulmonary bypass: A metaanalysis of cohort studies. Am J Kidney Dis [Internet]. 2015;65(2):283-93. Available from: http://dx.doi. org/10.1053/j.ajkd.2014.09.008
  • 35. Peng QY, Zhang LN, Ai YH, Zhang LM. Epidemiology of acute kidney injury in intensive care septic patients based on the KDIGO guidelines. Chin Med J (Engl). 2014;127(10):1820-6. https://doi.org/10.1080/15548627.2015.1100356
  • 36. Rodrigues FB, Bruetto RG, Torres US, Otaviano AP, Zanetta DMT, Burdmann EA. Incidence and Mortality of Acute Kidney Injury after Myocardial Infarction: A Comparison between KDIGO and RIFLE Criteria. PLoS One. 2013;8(7):1-8. https://doi.org/10.1371/journal.pone.0069998
  • 37. Lopes JA, Fernandes P, Jorge S, Gonçalves S, Alvarez A, Costa e Silva Z, et al. Acute kidney injury in intensive care unit patients: A comparison between the RIFLE and the Acute Kidney Injury Network classifications. Crit Care. 2008;12(4):1-8. https://doi.org/10.1186/cc6997
  • 38. Chang C-H, Lin C, Tian Y, Jenq C, Chang M, Chen Y, et al. Acute kidney injury classification. Shock. 2010;33(3): 247-52. https://doi.org/10.1097/SHK.0b013e3181b2fe0c
  • 39. Roy AK, Mc Gorrian C, Treacy C, Kavanaugh E, Brennan A, Mahon NG, et al. A comparison of traditional and novel definitions (RIFLE, AKIN, and KDIGO) of acute kidney injury for the prediction of outcomes in acute decompensated heart failure. CardioRenal Med. 2013;3(1):26-37. https://doi.org/10.1159/000347037
APA Uğur Y, Açıkel A, ÖZTÜRK T, Yildirim F, AMANVERMEZ ŞENARSLAN D, özyurt b, Çivi M (2020). Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. , 1 - 9. 10.5222/GKDAD.2020.86547
Chicago Uğur Yasin Levent,Açıkel Arzu,ÖZTÜRK Tulun,Yildirim Funda,AMANVERMEZ ŞENARSLAN Dilşad,özyurt beyhan cengiz,Çivi Melek Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. (2020): 1 - 9. 10.5222/GKDAD.2020.86547
MLA Uğur Yasin Levent,Açıkel Arzu,ÖZTÜRK Tulun,Yildirim Funda,AMANVERMEZ ŞENARSLAN Dilşad,özyurt beyhan cengiz,Çivi Melek Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. , 2020, ss.1 - 9. 10.5222/GKDAD.2020.86547
AMA Uğur Y,Açıkel A,ÖZTÜRK T,Yildirim F,AMANVERMEZ ŞENARSLAN D,özyurt b,Çivi M Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. . 2020; 1 - 9. 10.5222/GKDAD.2020.86547
Vancouver Uğur Y,Açıkel A,ÖZTÜRK T,Yildirim F,AMANVERMEZ ŞENARSLAN D,özyurt b,Çivi M Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. . 2020; 1 - 9. 10.5222/GKDAD.2020.86547
IEEE Uğur Y,Açıkel A,ÖZTÜRK T,Yildirim F,AMANVERMEZ ŞENARSLAN D,özyurt b,Çivi M "Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması." , ss.1 - 9, 2020. 10.5222/GKDAD.2020.86547
ISNAD Uğur, Yasin Levent vd. "Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması". (2020), 1-9. https://doi.org/10.5222/GKDAD.2020.86547
APA Uğur Y, Açıkel A, ÖZTÜRK T, Yildirim F, AMANVERMEZ ŞENARSLAN D, özyurt b, Çivi M (2020). Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi, 26(1), 1 - 9. 10.5222/GKDAD.2020.86547
Chicago Uğur Yasin Levent,Açıkel Arzu,ÖZTÜRK Tulun,Yildirim Funda,AMANVERMEZ ŞENARSLAN Dilşad,özyurt beyhan cengiz,Çivi Melek Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi 26, no.1 (2020): 1 - 9. 10.5222/GKDAD.2020.86547
MLA Uğur Yasin Levent,Açıkel Arzu,ÖZTÜRK Tulun,Yildirim Funda,AMANVERMEZ ŞENARSLAN Dilşad,özyurt beyhan cengiz,Çivi Melek Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi, vol.26, no.1, 2020, ss.1 - 9. 10.5222/GKDAD.2020.86547
AMA Uğur Y,Açıkel A,ÖZTÜRK T,Yildirim F,AMANVERMEZ ŞENARSLAN D,özyurt b,Çivi M Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi. 2020; 26(1): 1 - 9. 10.5222/GKDAD.2020.86547
Vancouver Uğur Y,Açıkel A,ÖZTÜRK T,Yildirim F,AMANVERMEZ ŞENARSLAN D,özyurt b,Çivi M Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması. Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi. 2020; 26(1): 1 - 9. 10.5222/GKDAD.2020.86547
IEEE Uğur Y,Açıkel A,ÖZTÜRK T,Yildirim F,AMANVERMEZ ŞENARSLAN D,özyurt b,Çivi M "Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması." Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi, 26, ss.1 - 9, 2020. 10.5222/GKDAD.2020.86547
ISNAD Uğur, Yasin Levent vd. "Kardiyak Cerrahi Geçiren Hastalarda RIFLE, ID AKIN ve KDIGO Sınıflamalarının Karşılaştırılması". Göğüs Kalp Damar Anestezi ve Yoğun Bakım Derneği Dergisi 26/1 (2020), 1-9. https://doi.org/10.5222/GKDAD.2020.86547