Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography
Yıl: 2020 Cilt: 37 Sayı: 1 Sayfa Aralığı: 9 - 14 Metin Dili: İngilizce DOI: 10.4274/balkanmedj.galenos.2019.2019.5.5 İndeks Tarihi: 07-12-2020
Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography
Öz: Background: Optical coherence tomography angiography allows adetailed evaluation of retinal and choroidal microvascular structureswithout the need for a contrast agent. Pseudoexfoliation syndromeis a condition that leads to anatomical and functional losses due toaccumulation of degraded abnormal fibrillar material in the intraocularand extraocular tissues. Histopathological studies have shown that theaccumulation of Pseudoexfoliation syndrome material in the vascularstructures may play a role in different ocular pathologies such asretinal vein occlusion, iris hypoperfusion, anterior segment hypoxia,retinal arterial occlusion, and neovascular glaucoma.Aims: To evaluate and compare flow and vascular density in theretina and choroid in eyes with Pseudoexfoliation syndrome, felloweyes without Pseudoexfoliation syndrome, and healthy eyes usingoptical coherence tomography angiography.Study Design: Case control study.Methods: The study included 35 eyes with Pseudoexfoliationsyndrome of 35 Pseudoexfoliation syndrome patients, 32 felloweyes without Pseudoexfoliation syndrome of 32 unilateralPseudoexfoliation syndrome patients, and 35 eyes of healthy controlsubjects. Flow area and vascular density in the superficial capillaryplexus and deep capillary plexus were measured by optical coherencetomography angiography as three separate parameters: total,parafoveal, and foveal. Choroidal thickness and foveal avascular zonearea were measured for each patient.Results: There were significant differences between thePseudoexfoliation syndrome eyes and control eyes in total, parafoveal,and foveal flow and vascular density in the superficial capillary plexus(p<0.05 for all), while there were no significant differences betweenthese groups in any of the flow or vascular density values in the deepcapillary plexus (p>0.05). None of the superficial capillary plexusand deep capillary plexus flow and vascular density values showedsignificant differences between Pseudoexfoliation syndrome eyes andnon-Pseudoexfoliation syndrome fellow eyes or between the nonPseudoexfoliation syndrome fellow eyes and control eyes (p>0.05).Choroidal thickness was significantly lower in Pseudoexfoliationsyndrome eyes compared to control eyes. Foveal avascular zonearea was significantly enlarged in Pseudoexfoliation syndrome eyescompared to control eyes in both the superficial and deep layers(p<0.05).Conclusion: Pseudoexfoliation syndrome eyes exhibit significantdamage to the retinal and choroidal vascular structures
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Feke GT, Goger DG, Tagawa H, Delori FC. Laser Doppler technique for absolute measurement of blood speed in retinal vessels. IEEE Trans Biomed Eng 1987;34:673- 80.
- 2. Sambhav K, Grover S, Chalam KV. The application of optical coherence tomography angiography in retinal diseases. Surv Ophthalmol 2017;62:838-66.
- 3. Ritch R, Schlotzer-Schrehardt U. Exfoliation syndrome. Surv Ophthalmol 2001;45:265-315.
- 4. Mitchell P, Wang JJ, Smith W. Association of pseudoexfoliation syndrome with increased vascular risk. Am J Ophthalmol 1997;124:685-7.
- 5. Schlötzer-Schrehardt UM, Koca MR, Naumann GO, Volkholz H. Pseudoexfoliation syndrome: ocular manifestation of a systemic disorder? Arch Ophthalmol 1992;110:1752-6.
- 6. Cursiefen C, Händel A, Schönherr U, Naumann GO. Pseudoexfoliation syndrome in patients with retinal vein branch and central vein thrombosis. Klin Monabl Augenheilkd 1997;211:17-21.
- 7. Asano N, Schlötzer-Schrehardt U, Naumann GO. A histopathologic study of iris changes in pseudoexfoliation syndrome. Ophthalmology 1995;102:1279-90.
- 8. Karjalainen K, Tarkkanen A, Merenmies L. Exfoliation syndrome in enucleated haemorrhagic and absolute glaucoma. Acta Ophthalmol (Copenh) 1987;65:320-2.
- 9. Rebolleda G, Pérez-Sarriegui A, De Juan V, Ortiz-Toquero S, Muñoz-Negrete FJ. A comparison of two optical coherence tomography-angiography devices in pseudoexfoliation glaucoma versus primary open-angle glaucoma and healthy subjects. Eur J Ophthalmol 2019;29:636-44.
- 10. Yüksel N, Karabas VL, Arslan A, Demirci A, Caglar Y. Ocular hemodynamics in pseudoexfoliation syndrome and pseudoexfoliation glaucoma. Ophthalmology 2001;108:1043-9.
- 11. Ocakoglu O, Koyluoglu N, Kayiran A, Tamcelik N, Ozkan S. Microvascular blood flow of the optic nerve head and peripapillary retina in unilateral exfoliation syndrome. Acta Ophthalmol Scand 2004;82:49-53.
- 12. Kocaturk T, Isikligil I, Uz B, Dayanir V, Dayanir YO. Ophthalmic artery blood flow parameters in pseudoexfoliation glaucoma. Eur J Ophthalmol 2016;26:124-7.
- 13. Cursiefen C, Hammer T, Küchle M, Naumann GO, Schlötzer-Schrehardt U. Pseudoexfoliation syndrome in eyes with ischemic central retinal vein occlusion A histopathologic and electron microscopic study. Acta Ophthalmol Scand 2001;79:476-8.
- 14. Karagiannis D, Kontadakis GA, Klados NE, Tsoumpris I, Kandarakis AS, Parikakis EA, et al. Central retinal vein occlusion and pseudoexfoliation syndrome. Clin Interv Aging 2015;10:879-83.
- 15. Park JH, Yoo C. Peripapillary Vessel Density in Glaucomatous Eyes: Comparison Between Pseudoexfoliation Glaucoma and Primary Open-angle Glaucoma. J Glaucoma 2019;28:36.
- 16. Kromer R, Glusa P, Framme C, Pielen A, Junker B. Optical coherence tomography angiography analysis of macular flow density in glaucoma. Acta Ophthalmol 2019;97:199-206.
- 17. Eltutar K, Acar F, Kayaarası Öztürker Z, Ünsal E, Özdoğan Erkul S. Structural Changes in Pseudoexfoliation Syndrome Evaluated with Spectral Domain Optical Coherence Tomography. Curr Eye Res 2016;41:513-20.
- 18. Freiberg FJ, Pfau M, Wons J, Wirth MA, Becker MD, Michels S. Optical coherence tomography angiography of the foveal avascular zone in diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol 2016;254:1051-8.
- 19. Wons J, Pfau M, Wirth MA, Freiberg FJ, Becker MD, Michels S. Optical Coherence Tomography Angiography of the Foveal Avascular Zone in Retinal Vein Occlusion. Ophthalmologica 2016;235:195-202.
- 20. Puska PM. Unilateral exfoliation syndrome: conversion to bilateral exfoliation and to glaucoma: a prospective 10- year follow-up study. J Glaucoma 2002;11:517-24.
- 21. Hammer T, Schlötzer-Schrehardt U, Naumann GO. Unilateral or asymmetric pseudoexfoliation syndrome? An ultrastructural study. Arch Ophthalmol 2001;119:1023-31.
- 22. Demircan S, Yılmaz U, Küçük E, Ulusoy MD, Ataş M, Gülhan A, et al. The Effect of Pseudoexfoliation Syndrome on the Retinal Nerve Fiber Layer and Choroid Thickness. Semin Ophthalmol 2017;32:341-7.
- 23. Eroglu FC, Asena L, Simsek C, Kal A, Yılmaz G. Evaluation of choroidal thickness using enhanced depth imaging by spectral-domain optical coherence tomography in patients with pseudoexfoliation syndrome. Eye 2015;29:791-6.
- 24. Zengin MO, Karti O, Karahan E, Kusbeci T. An Evaluation of the Relationship Between Clinically Unilateral Pseudoexfoliation Syndrome and Age-Related Macular Degeneration. Ophthalmic Surg Lasers Imaging Retina 2018;49:12-9.
- 25. Bleich S, Roedl J, Von Ahsen N, Schlötzer-Schrehardt U, Reulbach U, Beck G, et al. Elevated Homocysteine Levels in Aqueous Humor of Patients With Pseudoexfoliation Glaucoma. Am J Ophthalmol 2004;138:162-4.
- 26. Janciauskiene S, Krakau T. Alzheimer’s peptide: a possible link between glaucoma, exfoliation syndrome and Alzheimer’s disease. Acta Ophthalmol Scand 2001;79:328- 9.
- 27. Koliakos GG, Konstas AG, Schlötzer-Schrehardt U, Hollo G, Mitova D, Kovatchev D, et al. Endothelin-1 concentration is increased in the aqueous humour of patients with exfoliation syndrome. Br J Ophthalmol 2004;88:523-7.
- 28. Kotikoski H, Moilanen E, Vapaatalo H, Aine E. Biochemical markers of the L-arginine-nitric oxide pathway in the aqueous humour in glaucoma patients. Acta Ophthalmol Scand 2002;80:191-5.
| APA | CİNAR E, Yuce B, ASLAN M (2020). Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. , 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| Chicago | CİNAR ESAT,Yuce Berna,ASLAN M. Fatih Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. (2020): 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| MLA | CİNAR ESAT,Yuce Berna,ASLAN M. Fatih Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. , 2020, ss.9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| AMA | CİNAR E,Yuce B,ASLAN M Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. . 2020; 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| Vancouver | CİNAR E,Yuce B,ASLAN M Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. . 2020; 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| IEEE | CİNAR E,Yuce B,ASLAN M "Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography." , ss.9 - 14, 2020. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| ISNAD | CİNAR, ESAT vd. "Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography". (2020), 9-14. https://doi.org/10.4274/balkanmedj.galenos.2019.2019.5.5 |
| APA | CİNAR E, Yuce B, ASLAN M (2020). Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. Balkan Medical Journal, 37(1), 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| Chicago | CİNAR ESAT,Yuce Berna,ASLAN M. Fatih Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. Balkan Medical Journal 37, no.1 (2020): 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| MLA | CİNAR ESAT,Yuce Berna,ASLAN M. Fatih Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. Balkan Medical Journal, vol.37, no.1, 2020, ss.9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| AMA | CİNAR E,Yuce B,ASLAN M Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. Balkan Medical Journal. 2020; 37(1): 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| Vancouver | CİNAR E,Yuce B,ASLAN M Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography. Balkan Medical Journal. 2020; 37(1): 9 - 14. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| IEEE | CİNAR E,Yuce B,ASLAN M "Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography." Balkan Medical Journal, 37, ss.9 - 14, 2020. 10.4274/balkanmedj.galenos.2019.2019.5.5 |
| ISNAD | CİNAR, ESAT vd. "Retinal and Choroidal Vascular Changes in Eyes with Pseudoexfoliation Syndrome: A Comparative Study Using Optical Coherence Tomography Angiography". Balkan Medical Journal 37/1 (2020), 9-14. https://doi.org/10.4274/balkanmedj.galenos.2019.2019.5.5 |
