Yıl: 2019 Cilt: 38 Sayı: 1 Sayfa Aralığı: 10 - 17 Metin Dili: İngilizce DOI: 10.30782/uluvfd.445316 İndeks Tarihi: 21-02-2021

Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats

Öz:
Nesfatin-1 is an anorexic nucleobindin-2 -derived peptide and it has directly and centrally effect on the heart. The current study was designedto determine the effect of centrally and peripherally administered nesfatin-1 on electrocardiography (ECG) of healthy both fasted rats for 12h and satiated rats fed ad libitum. In order to record ECG, the electrodes were placed limbs of at lead II under ketamine (50 mg/kg; im) andxylazine (20 mg/kg; im) anesthesia mix.Centrally administered different doses of nesfatin-1 (100 and 200 pmol; icv) resulted in dose- and time-dependently a statistically significantincrease (p <0.05) in T wave, Q-T interval, and R-R interval duration without changing in ECG waves’ amplitude in both satiated and fastedrats. In a similar way, peripheral administration of nesfatin-1 (80 μg/kg; iv) in satiated rats prolonged statistically significant (p <0.05) T wave,Q-T interval, and R-R interval without producing a change in ECG waves’ amplitude. Moreover, icv administered nesfatin-1 in fasted andsatiated rats, and iv injected nesfatin-1 in satiated rats induced a statistically significant decrease in heart rate (p <0.05).In conclusion, our findings suggest that centrally and peripherally administrated nesfatin-1 caused a delay in T wave, Q-T interval and twoR-waves interval duration in ECG so that leading to a bradycardic effect in heart rate.
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APA ÇİFTÇİ K, Guvenc Bayram G, baş a, Yalcin M (2019). Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. , 10 - 17. 10.30782/uluvfd.445316
Chicago ÇİFTÇİ Kübra,Guvenc Bayram Gokcen,baş ayşenur,Yalcin Murat Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. (2019): 10 - 17. 10.30782/uluvfd.445316
MLA ÇİFTÇİ Kübra,Guvenc Bayram Gokcen,baş ayşenur,Yalcin Murat Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. , 2019, ss.10 - 17. 10.30782/uluvfd.445316
AMA ÇİFTÇİ K,Guvenc Bayram G,baş a,Yalcin M Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. . 2019; 10 - 17. 10.30782/uluvfd.445316
Vancouver ÇİFTÇİ K,Guvenc Bayram G,baş a,Yalcin M Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. . 2019; 10 - 17. 10.30782/uluvfd.445316
IEEE ÇİFTÇİ K,Guvenc Bayram G,baş a,Yalcin M "Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats." , ss.10 - 17, 2019. 10.30782/uluvfd.445316
ISNAD ÇİFTÇİ, Kübra vd. "Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats". (2019), 10-17. https://doi.org/10.30782/uluvfd.445316
APA ÇİFTÇİ K, Guvenc Bayram G, baş a, Yalcin M (2019). Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. Journal of research in veterinary medicine (Online), 38(1), 10 - 17. 10.30782/uluvfd.445316
Chicago ÇİFTÇİ Kübra,Guvenc Bayram Gokcen,baş ayşenur,Yalcin Murat Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. Journal of research in veterinary medicine (Online) 38, no.1 (2019): 10 - 17. 10.30782/uluvfd.445316
MLA ÇİFTÇİ Kübra,Guvenc Bayram Gokcen,baş ayşenur,Yalcin Murat Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. Journal of research in veterinary medicine (Online), vol.38, no.1, 2019, ss.10 - 17. 10.30782/uluvfd.445316
AMA ÇİFTÇİ K,Guvenc Bayram G,baş a,Yalcin M Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. Journal of research in veterinary medicine (Online). 2019; 38(1): 10 - 17. 10.30782/uluvfd.445316
Vancouver ÇİFTÇİ K,Guvenc Bayram G,baş a,Yalcin M Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats. Journal of research in veterinary medicine (Online). 2019; 38(1): 10 - 17. 10.30782/uluvfd.445316
IEEE ÇİFTÇİ K,Guvenc Bayram G,baş a,Yalcin M "Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats." Journal of research in veterinary medicine (Online), 38, ss.10 - 17, 2019. 10.30782/uluvfd.445316
ISNAD ÇİFTÇİ, Kübra vd. "Effect of Central and Peripheral Injected Nesfatin-1 on Electrocardiography in Rats". Journal of research in veterinary medicine (Online) 38/1 (2019), 10-17. https://doi.org/10.30782/uluvfd.445316