CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS

Selin ÇİM, (Eskişehir Teknik Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Eskişehir, Türkiye)
Hülya ALTUNTAŞ, (Eskişehir Teknik Üniversitesi, Fen Fakültesi, Biyoloji Bölümü, Eskişehir, Türkiye)
AYŞE AK CAN (Kocaeli Üniversitesi, Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Görüntüleme Teknikleri Programı, Kocaeli, Türkiye)
Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online)
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Yıl: 2020 Cilt: 9 Sayı: 2 Sayfa Aralığı: 219 - 225 Metin Dili: İngilizce DOI: 10.18036/estubtdc.616713 İndeks Tarihi: 14-01-2021

CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS

Öz:
In the treatment of brain cancer, the inhibition of cancer cell proliferation using anti-cancer agents is a priority approach. Venomof endoparasitoid wasps also may be a candidate for the development of new therapeutic agents. In this context, endoparasitoidPimpla turionellae L. (Hymenoptera: Ichneumonidae) venom may have an anti-carcinogenic effect on glioblastoma that resiststraditional therapies by various mechanisms. Therefore, we aimed to investigate endoparasitoid venom cytotoxicity onglioblastoma cells. For this purpose, the cytotoxic potential of venom from P. turionellae was evaluated on rat C6 glioblastomacell lines with methyl thiazolyl tetrazolium assay (MTT assay). P. turionellae venom was isolated from 15±2 day-old females.Different concentrations of P. turionellae venom (176.6-1.83 μg/ml) were applied to C6 rat glioblastoma cells in vitro. Resultsof MTT assay showed that the viability of C6 cells in vitro significantly decreased depending on the parasitoid venomconcentrations. Therefore, P. turionellae venom showed cytotoxic activity in a time- and dose-dependent manner. Inconclusion, the results from this research could be used as primary data of venom cytotoxicity for the investigation of newchemotherapeutic agents against malignant tumors.
Anahtar Kelime:

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APA Çim S, ALTUNTAS H, Ak A (2020). CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. , 219 - 225. 10.18036/estubtdc.616713
Chicago Çim Selin,ALTUNTAS HULYA,Ak Ayşe CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. (2020): 219 - 225. 10.18036/estubtdc.616713
MLA Çim Selin,ALTUNTAS HULYA,Ak Ayşe CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. , 2020, ss.219 - 225. 10.18036/estubtdc.616713
AMA Çim S,ALTUNTAS H,Ak A CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. . 2020; 219 - 225. 10.18036/estubtdc.616713
Vancouver Çim S,ALTUNTAS H,Ak A CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. . 2020; 219 - 225. 10.18036/estubtdc.616713
IEEE Çim S,ALTUNTAS H,Ak A "CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS." , ss.219 - 225, 2020. 10.18036/estubtdc.616713
ISNAD Çim, Selin vd. "CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS". (2020), 219-225. https://doi.org/10.18036/estubtdc.616713
APA Çim S, ALTUNTAS H, Ak A (2020). CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online), 9(2), 219 - 225. 10.18036/estubtdc.616713
Chicago Çim Selin,ALTUNTAS HULYA,Ak Ayşe CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online) 9, no.2 (2020): 219 - 225. 10.18036/estubtdc.616713
MLA Çim Selin,ALTUNTAS HULYA,Ak Ayşe CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online), vol.9, no.2, 2020, ss.219 - 225. 10.18036/estubtdc.616713
AMA Çim S,ALTUNTAS H,Ak A CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online). 2020; 9(2): 219 - 225. 10.18036/estubtdc.616713
Vancouver Çim S,ALTUNTAS H,Ak A CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS. Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online). 2020; 9(2): 219 - 225. 10.18036/estubtdc.616713
IEEE Çim S,ALTUNTAS H,Ak A "CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS." Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online), 9, ss.219 - 225, 2020. 10.18036/estubtdc.616713
ISNAD Çim, Selin vd. "CYTOTOXICITY OF VENOM FROM ENDOPARASITOID PIMPLA TURIONELLAE L. (HYMENOPTERA: ICHNEUMONIDAE) ON GLIOBLASTOMA CELLS". Eskişehir Teknik Üniversitesi Bilim ve Teknoloji Dergisi C- yaşam Bilimleri ve Biyoteknoloji (Online) 9/2 (2020), 219-225. https://doi.org/10.18036/estubtdc.616713
Sayfa Oluşturulma Tarihi
23-04-2024 16:29

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