Aim: The aim of this study was to evaluate whether there is a protective effect of iloprost which has antioxidant properties on tuba uterine tissue after I/R injury in rats. Materials and Method: In our study; 32 female Sprague Dawley rats were used. The groups were determined as sham, torsion, detorsion and detorsion + iloprost. Torsion was performed in all rats except sham group. Three hours of torsion in the torsion group, 3 hours of torsion in the detorsion group + 3 hours of torsion, 3 hours of torsion in the I/R + iloprost group, 3 hours of torsion and 60 minutes of intravenous iloprot infusion at the beginning of detorsion. Histological follow-up of the tuba uterine tissues were performed for histopathological evaluation. Then, 7 micron thick sections were taken and stained with Hematoxylin-Eosin (H-E) stain. Light microscopic examination was performed on the sections. Results: No histopathological findings were found in the control group in the uterine examinations. Unlike the control group, vascular occlusion and vacuolization of the epithelium occurred in the torsion group. In the detorsion group, the integrity of the epithelium was observed. No histopathologic condition was found in the images of the iloprost group except for the hemorrhagic areas. However, connective tissue, muscular areas and serosa layers were normal in all groups. Conclusion: It was observed that iloprost used for treatment because of antioxidant and vasodilator effect had protective effect on rat tuba uterine tissue after I/R injury. In line with these results, it was thought that the risk of ectopic pregnancy on the torsion side could be reduced by re-functionalizing the organ.