Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients

Kilic, Basak; mete, ayşe özlem; KAYA UGUR, Berna; Cicek, Hulya; Ganidagli, Suleyman

doi:10.5505/ejm.2021.25986

Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients

Basak Kilic, (Gaziantep Ersin Arslan Training Hospital, Department of Anesthesiology and Reanimation, Gaziantep, Turkey)

HÜLYA ÇİÇEK, (Gaziantep University, Faculty of Medicine, Department of Biochemistry, Gaziantep, Turkey)

Ayse Ozlem METE, (Gaziantep University, Faculty of Medicine, Department of Infectious Diseases, Gaziantep, Turkey)

Suleyman Ganidagli, (Gaziantep University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Gaziantep, Turkey)

Berna Kaya UĞUR (Gaziantep University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Gaziantep, Turkey)

Eastern Journal of Medicine

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Yıl: 2021 Cilt: 26 Sayı: 1 Sayfa Aralığı: 157 - 164 Metin Dili: İngilizce DOI: 10.5505/ejm.2021.25986 İndeks Tarihi: 02-05-2021

Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients

Öz:

The purpose of this study was to investigate the effect of parentera l Glutamine (Gln) supplementation on Endocan levels in patients with sepsis receiving parenteral nutrition. A total of 60 patients with a diagnosis of sepsis were enrolled to the study. Patients were randomly divided into two groups to receive either standard parenteral nutrition or standard parenteral nutrition plus the parenteral dipeptide Gln-Ala. The Gln-Ala dipeptide dosage was calculated to be 0.35 mg/kg. Demographic data, CRP, ESR, lactate, WBC, Endocan serum levels, APACHE II scores at admission to ICU, and SOFA scores at day 0, 3rd and 7th days were all recorded. The outcomes of the patients were also recorded after 28-day follow up. Results: There was no statistically significant difference between the Endocan values of patients receiving parente ral dipeptide Gln-Ala plus the standard parenteral nutrition vs standard parenteral nutrition. Also, there was no significant difference in mortality and septic shock development rates between the two groups.According to our results, there was not a significant difference regarding outcomes of the patients in both study groups, including mortality rates and there was no beneficial effect of indiscriminate GLN supplementation. Further prospective studies with larger sample size are needed in order to make conclusive comments that there is no beneficial effect of administering GLN.

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APA	Kilic B, Cicek H, mete a, Ganidagli S, KAYA UGUR B (2021). Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. , 157 - 164. 10.5505/ejm.2021.25986
Chicago	Kilic Basak,Cicek Hulya,mete ayşe özlem,Ganidagli Suleyman,KAYA UGUR Berna Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. (2021): 157 - 164. 10.5505/ejm.2021.25986
MLA	Kilic Basak,Cicek Hulya,mete ayşe özlem,Ganidagli Suleyman,KAYA UGUR Berna Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. , 2021, ss.157 - 164. 10.5505/ejm.2021.25986
AMA	Kilic B,Cicek H,mete a,Ganidagli S,KAYA UGUR B Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. . 2021; 157 - 164. 10.5505/ejm.2021.25986
Vancouver	Kilic B,Cicek H,mete a,Ganidagli S,KAYA UGUR B Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. . 2021; 157 - 164. 10.5505/ejm.2021.25986
IEEE	Kilic B,Cicek H,mete a,Ganidagli S,KAYA UGUR B "Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients." , ss.157 - 164, 2021. 10.5505/ejm.2021.25986
ISNAD	Kilic, Basak vd. "Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients". (2021), 157-164. https://doi.org/10.5505/ejm.2021.25986

APA	Kilic B, Cicek H, mete a, Ganidagli S, KAYA UGUR B (2021). Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. Eastern Journal of Medicine, 26(1), 157 - 164. 10.5505/ejm.2021.25986
Chicago	Kilic Basak,Cicek Hulya,mete ayşe özlem,Ganidagli Suleyman,KAYA UGUR Berna Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. Eastern Journal of Medicine 26, no.1 (2021): 157 - 164. 10.5505/ejm.2021.25986
MLA	Kilic Basak,Cicek Hulya,mete ayşe özlem,Ganidagli Suleyman,KAYA UGUR Berna Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. Eastern Journal of Medicine, vol.26, no.1, 2021, ss.157 - 164. 10.5505/ejm.2021.25986
AMA	Kilic B,Cicek H,mete a,Ganidagli S,KAYA UGUR B Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. Eastern Journal of Medicine. 2021; 26(1): 157 - 164. 10.5505/ejm.2021.25986
Vancouver	Kilic B,Cicek H,mete a,Ganidagli S,KAYA UGUR B Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients. Eastern Journal of Medicine. 2021; 26(1): 157 - 164. 10.5505/ejm.2021.25986
IEEE	Kilic B,Cicek H,mete a,Ganidagli S,KAYA UGUR B "Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients." Eastern Journal of Medicine, 26, ss.157 - 164, 2021. 10.5505/ejm.2021.25986
ISNAD	Kilic, Basak vd. "Effects of Parenteral Glutamine Supplementation onEndocan Levels in Septic Patients". Eastern Journal of Medicine 26/1 (2021), 157-164. https://doi.org/10.5505/ejm.2021.25986