The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients

Dirican, Melahat; Güllülü, Sümeyye; KOCA, Nizameddin; Şensoy, Barış; Kirhan, Emine; Sarandöl, Emre; ERSOY, ALPARSLAN

doi:10.18621/eurj.572606

The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients

Nizameddin KOCA, (Sağlık Bilimleri Üniversitesi, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, İç Hastalıkları Bölümü, Bursa, Türkiye)

Alparslan Ersoy, (Uludağ Üniversitesi, Tıp Fakültesi, Nefroloji ve Organ Nakli Anabilim Dalı, Bursa, Türkiye)

Barış Şensoy, (Sağlık Bilimleri Üniversitesi, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Bölümü, Bursa, Türkiye)

Emine Kırhan, (Tavşanlı Devlet Hastanesi, Biyokimya Bölümü, Kütahya, Türkiye)

Sümeyye GÜDÜLLÜ, (Uludağ Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Bursa, Türkiye)

Melahat Dirican, (Uludağ Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Bursa, Türkiye)

Emre Sarandöl (Uludağ Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Bursa, Türkiye)

The European Research Journal

1 0

Yıl: 2019 Cilt: 5 Sayı: 5 Sayfa Aralığı: 836 - 846 Metin Dili: İngilizce DOI: 10.18621/eurj.572606 İndeks Tarihi: 03-05-2021

The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients

Öz:

Objectives: Kidney transplantation recipients (KTRs) have higher cardiovascular complications risk comparedto the general population. Cardiovascular risk factors (CVRF, Traditional and non-traditional) are widely studiedto understand the causes of increased cardiovascular disease (CVD) risk in KTRs. Fetuin-A prevents fromvascular calcification (VC) by inhibiting production and collapsing of apatite crystals to the vascular wall. Therelationship between fetuin-A levels and CVRF in KTRs was investigated in this study.Methods: Sixty-two KTRs with no prior CVD history participated. Anthropometrical, laboratory (fetuin-A,inflammation markers, antioxidants, lipid peroxidation products) and cardiological (echocardiographic, pulsewave velocity) measurements were performed. Participants were divided into two groups according to normal(≥ 0.5 g/L, n = 32, NFA) and low (< 0.5 g/L, n = 30, LFA) fetuin-A levels according to manufacturer’s referencerange, and the results were compared.Results: No significant difference was observed in demographic features, body mass index, systolic anddiastolic blood pressures, left ventricle mass index, waist and hip circumferences, left ventricle hypertrophyand waist-hip ratios between the two groups (p > 0.05). The ratios of drug usage such as immunosuppressives,anti-hypertensives and statin were comparable between two groups. Parathormone levels were significantlyhigher in the NFA group (p = 0.015) and glomerular filtration rate was calculated significantly higher in LFAgroup (p = 007). The comparison of other CVRF reveals no significant difference (p > 0.05).Conclusions: Although many CVRF improved in KTRs, subclinical inflammation markers were still higherthan the healthy population. Identification and early recognition of CVRF in high-risk individuals maycontribute to the reduction of cardiovascular mortality. In our study, we observed no significant relationshipbetween fetuin-A levels and CVRFs. We evaluated the relationship between serum fetuin-A levels oncardiovascular risk factors by its role in pathophysiology.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KOCA N, ERSOY A, Şensoy B, Kirhan E, Güllülü S, Dirican M, Sarandöl E (2019). The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. , 836 - 846. 10.18621/eurj.572606
Chicago	KOCA Nizameddin,ERSOY ALPARSLAN,Şensoy Barış,Kirhan Emine,Güllülü Sümeyye,Dirican Melahat,Sarandöl Emre The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. (2019): 836 - 846. 10.18621/eurj.572606
MLA	KOCA Nizameddin,ERSOY ALPARSLAN,Şensoy Barış,Kirhan Emine,Güllülü Sümeyye,Dirican Melahat,Sarandöl Emre The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. , 2019, ss.836 - 846. 10.18621/eurj.572606
AMA	KOCA N,ERSOY A,Şensoy B,Kirhan E,Güllülü S,Dirican M,Sarandöl E The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. . 2019; 836 - 846. 10.18621/eurj.572606
Vancouver	KOCA N,ERSOY A,Şensoy B,Kirhan E,Güllülü S,Dirican M,Sarandöl E The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. . 2019; 836 - 846. 10.18621/eurj.572606
IEEE	KOCA N,ERSOY A,Şensoy B,Kirhan E,Güllülü S,Dirican M,Sarandöl E "The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients." , ss.836 - 846, 2019. 10.18621/eurj.572606
ISNAD	KOCA, Nizameddin vd. "The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients". (2019), 836-846. https://doi.org/10.18621/eurj.572606

APA	KOCA N, ERSOY A, Şensoy B, Kirhan E, Güllülü S, Dirican M, Sarandöl E (2019). The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. The European Research Journal, 5(5), 836 - 846. 10.18621/eurj.572606
Chicago	KOCA Nizameddin,ERSOY ALPARSLAN,Şensoy Barış,Kirhan Emine,Güllülü Sümeyye,Dirican Melahat,Sarandöl Emre The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. The European Research Journal 5, no.5 (2019): 836 - 846. 10.18621/eurj.572606
MLA	KOCA Nizameddin,ERSOY ALPARSLAN,Şensoy Barış,Kirhan Emine,Güllülü Sümeyye,Dirican Melahat,Sarandöl Emre The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. The European Research Journal, vol.5, no.5, 2019, ss.836 - 846. 10.18621/eurj.572606
AMA	KOCA N,ERSOY A,Şensoy B,Kirhan E,Güllülü S,Dirican M,Sarandöl E The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. The European Research Journal. 2019; 5(5): 836 - 846. 10.18621/eurj.572606
Vancouver	KOCA N,ERSOY A,Şensoy B,Kirhan E,Güllülü S,Dirican M,Sarandöl E The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients. The European Research Journal. 2019; 5(5): 836 - 846. 10.18621/eurj.572606
IEEE	KOCA N,ERSOY A,Şensoy B,Kirhan E,Güllülü S,Dirican M,Sarandöl E "The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients." The European Research Journal, 5, ss.836 - 846, 2019. 10.18621/eurj.572606
ISNAD	KOCA, Nizameddin vd. "The evaluation of the relationship between fetuin-A and traditional and non-traditional cardiovascular risk factors in kidney transplantation recipients". The European Research Journal 5/5 (2019), 836-846. https://doi.org/10.18621/eurj.572606