Looking at the world from a board perspective, having an innovative mindset, creating ideas that are in line with the environment with accelerating scientific and technological developments are possible only when individuals get a quality education. Individuals living in the modern world have to acquire complex skills. In line with this current necessity, educational institutions have undertaken the mission of educating and supporting students who can research, question and produce solutions to the problems they encounter. The active role of students in training processes has been prioritized in today’s educational institutions and Problem-Based Learning Approach (PBL) has accordingly become more important. The goal of this study is to make a conceptual analysis of the Problem-Based Learning approach and evaluate its availability in virtual environments by establishing a general framework of the approach. In line with this purpose, literature information about PBL, its benefits and limitations, the learning process, teacher and student roles and evaluation processes are firstly presented in the study; after setting this basis, information about the course of proceeding in terms of the use of PBL approach is presented. Virtual environments are qualified to meet some necessities of the PBL approach. However, it is crucial to carefully follow the application process; planning and organizing the sessions of PBL, which are highly important parts of the approach, are significant. The position of teachers as guides in this process and their ability to organize and guide the process correctly will contribute to the success of putting the PBL approach into practice. On the other hand, it is necessary to consider the different design principles while designing a virtual environment according to the PBL approach process.