Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus)
Yıl: 2021 Cilt: 68 Sayı: 2 Sayfa Aralığı: 181 - 184 Metin Dili: İngilizce DOI: 10.33988/auvfd.739352 İndeks Tarihi: 04-05-2021
Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus)
Öz: A biocidal product in gel form containing 0.05% fipronil active substance was used for pest control in the habitat of thirteen Squirrel Monkey (Saimiri sciureus) in a zoo. Following the application, sudden death was observed in three primates. Routine bacteriological, histopathological and toxicological analyses on one cadaver and tissue samples from the cadaver did not produce any pathogenic agent, pesticide and any pathognomonic findings. In an attempt to investigate the presence of known fipronil intoxication biomarkers, fipronil and fipronil sulfone, we applied modified QuEChERS extraction processes on tissue samples and determined the fipronil and fipronil sulfone levels as 27.1-3.5 μg/kg in cutaneous tissue and 13.8-47.2 μg/kg in brain tissue, respectively, by using UHPLC Q-Orbitrap Mass Spectrometer. In the light of the anamnesis, necropsy, microbiology and histopathology results, and after evaluating the presence of fipronil-fipronil sulfone in tissues, we considered that the deaths could have resulted from acute fipronil toxicity due to species-specific active substance susceptibility.
Anahtar Kelime: Sincap Maymununda (Saimiri sciureus) akut fipronil toksikasyonu
Öz: Bir hayvanat bahçesinde barındırılan on üç Sincap maymununun (Saimiri sciureus) yaşam alanında haşere mücadelesi amaçlı %0,05 fipronil etkin maddesi içeren jel formunda biyosidal ürün kullanılmıştır. Uygulamanın ardından üç primatta ani ölümşekillenmiştir. Ölen primatlardan bir tanesinin kadavrasında yapılan nekropsi ve akabinde alınan doku numunelerinde rutin bakteriyolojik, histopatolojik, toksikolojik analizler sonucu patojen etken, patognomik bulgu ve pestisite rastlanılmamıştır. Fiproniltoksikasyonu biyobelirteçleri olarak bilinen fipronil ve fipronil sülfon maddelerinin varlığının araştırılması için alınan doku numunelerine modifiye QuEChERS ekstraksiyon işlemleri uygulanmış ve UHPLC Q-Orbitrap Kütle Spektrometresi ile fipronil vefipronil sülfon sırasıyla deri dokusunda 27,1-3,5 μg/kg ve beyin dokusunda 13,8-47,2 μg/kg düzeyinde tespit edilmiştir. Anamnez, nekropsi, mikrobiyoloji ve histopatoloji bulguları ışığında, doku fipronil-fipronil sülfon varlığı değerlendirildiğinde türe özgü etkinmadde hassasiyeti olabileceği düşünülerek akut fipronil toksikasyonu sonucu ölüm şekillendiği kanaatine varılmıştır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
- 1. Alfaroa JWL, Boubli JP, Paim FP, et al (2015): Biogeography of squirrel monkeys (genus Saimiri): Southcentral Amazon origin and rapid pan-Amazonian diversification of a lowland primate. Mol Phylogenet Evol, 82, 436–454.
- 2. Anonymous (2011): Safety of Fipronil in Dogs and Cats: a review of literature, APVMA, 1-2. Available at https://apvma.gov.au/sites/default/files/publication/15191- fipronil-prf-vol2-animal-safety-literature_0.pdf. (Accessed November 20, 2019).
- 3. Bharathraj MY, Venugopal K, Jaligidad K, et al (2015): Fipronil compound consumption presenting as status epilepticus. Toxicol Int, 22, 165-166.
- 4. Boardman W, Unwin S (2009): Necropsy Procedures, Pan African Sanctuary Alliance Primate Veterinary Health Manual. Available at https://pasa.org/wpcontent/uploads/2016/04/PASA_Operations_Manual_2016 .pdf. (Accessed November 20, 2019).
- 5. Chen H, Gao G, Liu P, et al (2017): Development and validation of an ultra-performance liquid chromatography Q-Exactive Orbitrap mass spectrometry for the determination of fipronil and its metabolites in tea and chrysanthemum. Food Chem, 246, 328-334.
- 6. Gibbons D, Morrissey C, Mineau P (2015): A review of the direct and indirect effects of neonicotinoids and fipronil on vertebrate wildlife. Environ Sci Pollut, 22, 103-118.
- 7. Gunasekara AS, Troung T (2007): Environmental Fate of Fipronil, Environmental Monitoring Branch Department of Pesticide Regulation, 1001, CalEPA, USA. Available at https://pdfs.semanticscholar.org/758a/ed685ce8580266f55f 728204c8e5b9daa96a.pdf. (Accessed November 20, 2019).
- 8. Gupta RC, Milatovic D (2014): III- Chemical agents, solvents and gases toxicity biomarkers, Chapter 26 Incesticides. 467-468 In: R. Gupta (Ed), Biomarkers in Toxicology. Academic Press, San Diego.
- 9. Johnson-Delaney CA (2009): Parasites of captive nonhuman primates. Vet Clin North Am Exot Anim Pract, 12, 579.
- 10. Kim YA, Yoon YS, Kim HS, et al (2019): Distribution of fipronil in humans, and adverse health outcomes of in utero fipronil sulfone exposure in newborns. Int J Hyg Envir Heal, 222, 524–532.
- 11. Kitulagodage M, Isanhart J, Buttemer WA, et al (2010): Fipronil toxicity in northern bobwhite quail Colinus virginianus: reduced feeding behaviour and sulfone metabolite formation. Chemosphere, 83, 524-530.
- 12. Kitulagodage M (2011): Impact of fipronil, a new generation pesticide, on avian development and health, Doctor of Philosophy thesis, School of Health Sciences, University of Wollongong.
- 13. Krief S, Berny F, Gumisiriza F, et al (2017): Agricultural expansion as risk to endangered wildlife: Pesticide exposure in wild chimpanzees and baboons displaying facial dysplasia. Sci Total Environ, 598, 647-656.
- 14. Lee SJ, Mulay P, Dıebolt-Brown B, et al (2010): Acute illnesses associated with exposure to fipronil-surveillance data from 11 states in the United States, 2001-2007. Clin Toxicol, 48, 737-744.
- 15. Magalhães JZ, Sandini TM, Udo MSB, et al (2018): Fipronil: uses, pharmacological and toxicological features. Revinter, 11, 67-83.
- 16. Montanha PF, Machado FD, Faria CB, et al (2016): Lactational exposure to fipronil pesticide in low dose impairs memory in rat offspring. J Neurol Disord, 4, 1-7.
- 17. Montanha PF, Faria CA, Machado FD, et al (2018): Behavioral and laboratory abnormalities in rat offspring exposed to fipronil during the perinatal period. Int J Adv Vet Anim Res, 7, 356-373.
- 18. Pisa LW, Amaral-Rogers V, Belzunces LP, et al (2015): Effects of neonicotinoids and fipronil on non-target invertebrates. Environ Sci Pollut, 22, 68-102.
- 19. Poppenga RH, Oehme FW (2010): Pesticide Use and Associated Morbidity and Mortality in Veterinary Medicine. 285-301. In: R Krieger (Ed), Hayes' Handbook of Pesticide Toxicology. Academic Press, San Diego.
| APA | DEMİR O, ÖZDEMİR Ö, KOÇAK TOY A, Arslan Z, Sevin S (2021). Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). , 181 - 184. 10.33988/auvfd.739352 |
| Chicago | DEMİR Onur,ÖZDEMİR Özgen,KOÇAK TOY Asiye,Arslan Zeynel,Sevin Sedat Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). (2021): 181 - 184. 10.33988/auvfd.739352 |
| MLA | DEMİR Onur,ÖZDEMİR Özgen,KOÇAK TOY Asiye,Arslan Zeynel,Sevin Sedat Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). , 2021, ss.181 - 184. 10.33988/auvfd.739352 |
| AMA | DEMİR O,ÖZDEMİR Ö,KOÇAK TOY A,Arslan Z,Sevin S Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). . 2021; 181 - 184. 10.33988/auvfd.739352 |
| Vancouver | DEMİR O,ÖZDEMİR Ö,KOÇAK TOY A,Arslan Z,Sevin S Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). . 2021; 181 - 184. 10.33988/auvfd.739352 |
| IEEE | DEMİR O,ÖZDEMİR Ö,KOÇAK TOY A,Arslan Z,Sevin S "Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus)." , ss.181 - 184, 2021. 10.33988/auvfd.739352 |
| ISNAD | DEMİR, Onur vd. "Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus)". (2021), 181-184. https://doi.org/10.33988/auvfd.739352 |
| APA | DEMİR O, ÖZDEMİR Ö, KOÇAK TOY A, Arslan Z, Sevin S (2021). Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). Ankara Üniversitesi Veteriner Fakültesi Dergisi, 68(2), 181 - 184. 10.33988/auvfd.739352 |
| Chicago | DEMİR Onur,ÖZDEMİR Özgen,KOÇAK TOY Asiye,Arslan Zeynel,Sevin Sedat Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). Ankara Üniversitesi Veteriner Fakültesi Dergisi 68, no.2 (2021): 181 - 184. 10.33988/auvfd.739352 |
| MLA | DEMİR Onur,ÖZDEMİR Özgen,KOÇAK TOY Asiye,Arslan Zeynel,Sevin Sedat Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). Ankara Üniversitesi Veteriner Fakültesi Dergisi, vol.68, no.2, 2021, ss.181 - 184. 10.33988/auvfd.739352 |
| AMA | DEMİR O,ÖZDEMİR Ö,KOÇAK TOY A,Arslan Z,Sevin S Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2021; 68(2): 181 - 184. 10.33988/auvfd.739352 |
| Vancouver | DEMİR O,ÖZDEMİR Ö,KOÇAK TOY A,Arslan Z,Sevin S Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus). Ankara Üniversitesi Veteriner Fakültesi Dergisi. 2021; 68(2): 181 - 184. 10.33988/auvfd.739352 |
| IEEE | DEMİR O,ÖZDEMİR Ö,KOÇAK TOY A,Arslan Z,Sevin S "Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus)." Ankara Üniversitesi Veteriner Fakültesi Dergisi, 68, ss.181 - 184, 2021. 10.33988/auvfd.739352 |
| ISNAD | DEMİR, Onur vd. "Acute fipronil intoxication in Squirrel Monkey (Saimiri sciureus)". Ankara Üniversitesi Veteriner Fakültesi Dergisi 68/2 (2021), 181-184. https://doi.org/10.33988/auvfd.739352 |
