Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status

Cevher, Selim; SUKGEN, Emine Alyamac; KOCLUK, Yusuf

Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status

Emine Alyamac Sukgen, (Adana Numune Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, 01240 Adana, Türkiye)

Selim Cevher, (Hitit Üniversitesi Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, 019010 Çorum, Türkiye)

Yusuf Kocluk (Adana Numune Eğitim ve Araştırma Hastanesi, Göz Hastalıkları Kliniği, 01240 Adana, Türkiye)

Sakarya Tıp Dergisi

2 0

Yıl: 2019 Cilt: 9 Sayı: 1 Sayfa Aralığı: 141 - 147 Metin Dili: İngilizce İndeks Tarihi: 22-04-2021

Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status

Öz:

Objective To evaluate the effects of diode laser photocoagulation and intravitreal ranibizumab (IVR) treatments on axial lenght and refractive status development in the treatmentof retinopathy of premautrity (ROP). ( Sakarya Med J 2019, 9(1):141-147 )Materialsand MethodsThe study included 82 eyes of 41 patients who were 1 year adjusted age, underwent primarily diode laser photocoagulation or 0.25 mg/0.025 ml IVR. Axial lenght (AL)and spherical equivalent (SE) parameters were compared.Results Patients divided into two groups. Group 1 had 34 eyes of 17 patients who underwent IVR treatment and group 2 had 48 eyes of 24 patients who underwent diode laserphotocoagulation treatment. In group 1, AL were detected 19,86 1,104mm in right eyes and 19,73 1,062mm in left eyes. In group 2, AL were detected 19,90 0,83mm inright eyes and 19,86 0,842mm in left eyes (p>0.05). In group1 and 2, SE values were detected 0.44 2.053D and -0.02 3.07D in right eyes and 0.59 2.063D and -0.17 2.8in left eyesD, respectively ( p>0.05). There was no statistically significant differences between two groups about AL and SE values.Conclusion Myopia is seen higher in patients with ROP than healthy patients. Although using anti vascular growth factor in ROP has been increased last years, diode laserphotocoagulation is the gold standart therapy. In our study we compared the effects of diode laser photocoagulation and IVR on AL and SE. We did not find any statisticallysignificant difference. Further evaluation is needed.

Anahtar Kelime:

Prematüre Retinopatisinde uygulanan Diod Lazer Fotokoagülasyon ile İntravitreal Ranibizumab Tedavilerinin Gözün Aksiyel Uzunluğuna ve Refraktif Durumuna Olan Etkilerinin Karşılaştırılması

Öz:

Amaç Prematüre retinopatisi (PR) tedavisinde uygulanan diod laser fotokoagülasyon (LFK) ile intravitreal ranibizumab (IVR) tedavilerinin gözün aksiyel ve refraktif gelişimi üzerine olan etkilerini değerlendirmektir. ( Sakarya Tıp Dergisi 2019, 9(1):141-147 ). Gereç ve Yöntemler Kliniğimizde PR nedeniyle primer ve tek tedavi olarak LFK ve ya 0.25 mg/0.025 ml IVR tedavisi uygulanmış ve düzeltilmiş olarak bir yaşını doldurmuş 41 infantın 82 gözü çalışmaya dahil edilmiştir. Hastaların biyometri ile aksiyel uzunlukları(AU) ölçülmüş, sikloplejik muayene sonucu elde edilen refraktif değerleri sferik eküvalan olarak karşılaştırılmıştır. Bulgular IVR grubunda 17 hastanın 34 gözü Grup-1, LFK grubunda ise 24 hastanın 48 gözü Grup-2 olarak ayrıldı. Grup-1’de AU; sağ gözde 19,86 1,104mm; sol gözde 19,73 1,062mm idi. Grup-2’de sağ göz için 19,90 0,83mm sol göz için 19,86 0,842mm idi.(p>0.05) Refraktif değerler Grup-1’de sağ göz için 0.44 2.053D ; sol göz içinse 0.59 2.063D idi. Grup-2’de ise sağ göz -0.02 3.07D, sol göz ise -0.17 2.8 idi.( p>0.05) Her iki grupta hem aksiyel uzunluk açısından hem de sferik eküvalan açısından istatistiksel olarak anlamlı fark tespit edilmemiştir. Sonuç Prematüre retinopatili bebeklerde myopi gelişme oranı sağlıklı bebeklere göre daha yüksektir. Prematüre retinopatisi tedavisinde son yıllarda anti vasküler büyüme faktörü (Anti-Vebf) kullanımı hızla artmakla beraber LFK tedavisi altın standart tedavi olarak kullanılmaktadır. Çalışmamızda İVR tedavisi ile LFK tedavisinin aksiyel uzunluk ve sferik eküvalan değerleri üzerine yaptıkları etkiyi araştırdık ve bir fark bulamadık ama bu konuda daha fazla bilimsel çalışmaların yapılması gerektiğini düşünüyoruz.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	SUKGEN E, Cevher S, KOCLUK Y (2019). Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. , 141 - 147.
Chicago	SUKGEN Emine Alyamac,Cevher Selim,KOCLUK Yusuf Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. (2019): 141 - 147.
MLA	SUKGEN Emine Alyamac,Cevher Selim,KOCLUK Yusuf Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. , 2019, ss.141 - 147.
AMA	SUKGEN E,Cevher S,KOCLUK Y Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. . 2019; 141 - 147.
Vancouver	SUKGEN E,Cevher S,KOCLUK Y Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. . 2019; 141 - 147.
IEEE	SUKGEN E,Cevher S,KOCLUK Y "Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status." , ss.141 - 147, 2019.
ISNAD	SUKGEN, Emine Alyamac vd. "Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status". (2019), 141-147.

APA	SUKGEN E, Cevher S, KOCLUK Y (2019). Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. Sakarya Tıp Dergisi, 9(1), 141 - 147.
Chicago	SUKGEN Emine Alyamac,Cevher Selim,KOCLUK Yusuf Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. Sakarya Tıp Dergisi 9, no.1 (2019): 141 - 147.
MLA	SUKGEN Emine Alyamac,Cevher Selim,KOCLUK Yusuf Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. Sakarya Tıp Dergisi, vol.9, no.1, 2019, ss.141 - 147.
AMA	SUKGEN E,Cevher S,KOCLUK Y Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. Sakarya Tıp Dergisi. 2019; 9(1): 141 - 147.
Vancouver	SUKGEN E,Cevher S,KOCLUK Y Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status. Sakarya Tıp Dergisi. 2019; 9(1): 141 - 147.
IEEE	SUKGEN E,Cevher S,KOCLUK Y "Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status." Sakarya Tıp Dergisi, 9, ss.141 - 147, 2019.
ISNAD	SUKGEN, Emine Alyamac vd. "Comparison of Intravitreal Ranibizumab and Diod Laser Photocoagulation Treatment for Retinopathy of Prematurity; Effects on Axial Lenght and Refractive Status". Sakarya Tıp Dergisi 9/1 (2019), 141-147.