Objective Hereditary neuropathies are a group of progressive disease that leads to demyelination and / or loss of axons in the peripheral nervous system. Although hereditary neuropathies frequently occurs in familial form, sporadic cases are rarely seen. In our study, demographic, clinical, and electrophysiological characteristics of hereditary neuropathy patients in Sakarya province were investigated. ( Sakarya Med J 2019, 9(1):120-124 ) Materials and Methods Totally 26 registered patients who were diagnosed as hereditary sensorimotor neuropathy (HSMN) between 2011 and 2016 were recruited for this study. The data of these patients were analyzed retrospectively in terms of age, gender, age at symptoms onset, referral complaints, consanguineous marriage, clinical and electrophysiological findings, familial and genetic features. Results Of the 26 patients followed up in our clinic, 13 (50%) were male. The mean age of the patients was 41±12,29, while the mean age of the symptoms onset was 23,26±13,7. Electrophysiological examinations showed axonal neuropathy in 9, demyelinating neuropathy in 12, and mixed neuropathy in 5 cases. Genetic studies revealed heterozygous PMP 22 deletion in 5 cases and PMP 22 duplication in 2 cases. Therefore, 5 cases were diagnosed as Charcot Marie Tooth (CMT)-1A, 2 cases were diagnosed as hereditary pressure sensitive polyneuropathy (HNPP), while other 19 cases were evaluated as unclassified hereditary neuropathy. Conclusion Recent advances in the field of molecular biology have provided significant development in recognition of many unclassified types of hereditary neuropathies. In our study, the phenotypic characteristics of demyelinating type cases which can be genotyped in Turkey of Sakarya province was evaluated and compared with the literature.,