Yıl: 2020 Cilt: 46 Sayı: 2 Sayfa Aralığı: 225 - 235 Metin Dili: Türkçe DOI: https://doi.org/10.32708/uutfd.710919 İndeks Tarihi: 28-04-2021

İmmunoterapi ve Radyoterapi Kombinasyonu

Öz:
İmmunoterapi, bağışıklık sisteminin güçlendirilmesi ile birçok kanser türünde yanıt, yanıt süresi ve sağkalım açısından etkinliği kanıtlanmışbir tedavidir. Yanıt oranları %20 olup dirençli hastalarda immunoterapi ile sinerjik etki yaratan yeni tedavilere gereksinim vardır. Radyoterapi ile tümör hücrelerinden salınan antijenik uyarı tümörün bağışıklık sistemi tarafından daha kolay tanınmasını sağlayarakimmunoterapinin tamamlayıcısı olabilir. Radyoterapinin, ışınlanan hedef dışındaki metastazlar üzerindeki sistemik etkisi “abscopal” etkiolarak tanımlanmış olup immuno-radyoterapinin temel amacı “abscopal” etkiyi uyandırmaktır. İmmuno-radyoterapinin yanıt ve sağkalımaanlamlı katkısı öncelikle malign melanom ve akciğer kanserlerinde gösterilmiş olup diğer solid tümörlerde de gelecek vaat eden önemli birtedavi yöntemi olarak görülmektedir.
Anahtar Kelime:

Immunotherapy and Radiotherapy Combination

Öz:
Immunotherapy is a treatment proven to be effective in terms of response, duration of response and survival in many types of cancer by strengthening the immune system. The response rates are 20%, and new treatments that produce synergistic effect with immunotherapy are needed in resistant patients. Antigenic stimulation released from tumor cells with radiotherapy can complement immunotherapy by making the tumor more easily recognized by the immune system. The systemic effect of radiotherapy on metastases other than the irradiated target is defined as “abscopal” effect and the main purpose of immuno-radiotherapy is to evoke the “abscopal” effect. The significant contribution of immuno-radiotherapy to response and survival has been shown primarily in malignant melanoma and lung cancers, and is seen as a promising treatment method in other solit tumors as well.
Anahtar Kelime:

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APA Sarihan S (2020). İmmunoterapi ve Radyoterapi Kombinasyonu. , 225 - 235. https://doi.org/10.32708/uutfd.710919
Chicago Sarihan Sureyya İmmunoterapi ve Radyoterapi Kombinasyonu. (2020): 225 - 235. https://doi.org/10.32708/uutfd.710919
MLA Sarihan Sureyya İmmunoterapi ve Radyoterapi Kombinasyonu. , 2020, ss.225 - 235. https://doi.org/10.32708/uutfd.710919
AMA Sarihan S İmmunoterapi ve Radyoterapi Kombinasyonu. . 2020; 225 - 235. https://doi.org/10.32708/uutfd.710919
Vancouver Sarihan S İmmunoterapi ve Radyoterapi Kombinasyonu. . 2020; 225 - 235. https://doi.org/10.32708/uutfd.710919
IEEE Sarihan S "İmmunoterapi ve Radyoterapi Kombinasyonu." , ss.225 - 235, 2020. https://doi.org/10.32708/uutfd.710919
ISNAD Sarihan, Sureyya. "İmmunoterapi ve Radyoterapi Kombinasyonu". (2020), 225-235. https://doi.org/https://doi.org/10.32708/uutfd.710919
APA Sarihan S (2020). İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(2), 225 - 235. https://doi.org/10.32708/uutfd.710919
Chicago Sarihan Sureyya İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46, no.2 (2020): 225 - 235. https://doi.org/10.32708/uutfd.710919
MLA Sarihan Sureyya İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol.46, no.2, 2020, ss.225 - 235. https://doi.org/10.32708/uutfd.710919
AMA Sarihan S İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2020; 46(2): 225 - 235. https://doi.org/10.32708/uutfd.710919
Vancouver Sarihan S İmmunoterapi ve Radyoterapi Kombinasyonu. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2020; 46(2): 225 - 235. https://doi.org/10.32708/uutfd.710919
IEEE Sarihan S "İmmunoterapi ve Radyoterapi Kombinasyonu." Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46, ss.225 - 235, 2020. https://doi.org/10.32708/uutfd.710919
ISNAD Sarihan, Sureyya. "İmmunoterapi ve Radyoterapi Kombinasyonu". Uludağ Üniversitesi Tıp Fakültesi Dergisi 46/2 (2020), 225-235. https://doi.org/https://doi.org/10.32708/uutfd.710919