Yıl: 2020 Cilt: 46 Sayı: 2 Sayfa Aralığı: 237 - 245 Metin Dili: Türkçe DOI: https://doi.org/10.32708/uutfd.732671 İndeks Tarihi: 27-04-2021

Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli

Öz:
Drosophila melanogaster yaşam döngüsünün kısa olması, nükleotit dizisi bilinen küçük bir genoma sahip olması, insan hastalıklarına nedenolan genlerin birçoğunun ortoloğunu bulundurması, temel hücresel olayların/sinyal yolaklarının korunmuş olması ve etik problem yaratmaması gibi önemli avantajları olan omurgasız bir canlıdır. Bu avantajlar sayesinde insan hastalıklarının modellenmesi mümkün olmuş vepatofizyolojilerin araştırılması, yeni genlerin ve genetik düzenleyicilerin tanımlanması, klinik çeşitlilik nedenlerinin açıklanabilmesi ve yenitanı/tedavi geliştirme çalışmaları hız kazanmıştır. Bu derlemede Drosophila melanogaster’in model organizma olarak avantajları venörodejeneratif hastalıklarla ilişkili araştırmalarda kullanılmasına ilişkin bilgiler özetlenmiştir.
Anahtar Kelime:

Drosophila melanogaster Model in Neurodegenerative Disease Research

Öz:
Drosophila melanogaster is an invertebrate organism which has several advantages including having a short life cycle, a small genome with known sequence, orthologues of several human disease genes, conserved cellular processes/pathways without ethical concerns. Due to these advantages, human disease modellling is possible and research areas such as investigating pathophysiology, identifying new genes/modifiers, understanding the reasons of clinic variability, developing new diagnostics/therapeutics have been accelerated. In this review, advantages of Drosophila melanogaster as a model organism as well as its use in neurodegenerative diseases are summarized.
Anahtar Kelime:

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APA HAZIR C, Bora G, Erdem Yurter H (2020). Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. , 237 - 245. https://doi.org/10.32708/uutfd.732671
Chicago HAZIR Cem,Bora Gamze,Erdem Yurter Hayat Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. (2020): 237 - 245. https://doi.org/10.32708/uutfd.732671
MLA HAZIR Cem,Bora Gamze,Erdem Yurter Hayat Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. , 2020, ss.237 - 245. https://doi.org/10.32708/uutfd.732671
AMA HAZIR C,Bora G,Erdem Yurter H Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. . 2020; 237 - 245. https://doi.org/10.32708/uutfd.732671
Vancouver HAZIR C,Bora G,Erdem Yurter H Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. . 2020; 237 - 245. https://doi.org/10.32708/uutfd.732671
IEEE HAZIR C,Bora G,Erdem Yurter H "Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli." , ss.237 - 245, 2020. https://doi.org/10.32708/uutfd.732671
ISNAD HAZIR, Cem vd. "Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli". (2020), 237-245. https://doi.org/https://doi.org/10.32708/uutfd.732671
APA HAZIR C, Bora G, Erdem Yurter H (2020). Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46(2), 237 - 245. https://doi.org/10.32708/uutfd.732671
Chicago HAZIR Cem,Bora Gamze,Erdem Yurter Hayat Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. Uludağ Üniversitesi Tıp Fakültesi Dergisi 46, no.2 (2020): 237 - 245. https://doi.org/10.32708/uutfd.732671
MLA HAZIR Cem,Bora Gamze,Erdem Yurter Hayat Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. Uludağ Üniversitesi Tıp Fakültesi Dergisi, vol.46, no.2, 2020, ss.237 - 245. https://doi.org/10.32708/uutfd.732671
AMA HAZIR C,Bora G,Erdem Yurter H Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2020; 46(2): 237 - 245. https://doi.org/10.32708/uutfd.732671
Vancouver HAZIR C,Bora G,Erdem Yurter H Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli. Uludağ Üniversitesi Tıp Fakültesi Dergisi. 2020; 46(2): 237 - 245. https://doi.org/10.32708/uutfd.732671
IEEE HAZIR C,Bora G,Erdem Yurter H "Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli." Uludağ Üniversitesi Tıp Fakültesi Dergisi, 46, ss.237 - 245, 2020. https://doi.org/10.32708/uutfd.732671
ISNAD HAZIR, Cem vd. "Nörodejeneratif Hastalık Araştırmalarında Drosophila melanogaster Modeli". Uludağ Üniversitesi Tıp Fakültesi Dergisi 46/2 (2020), 237-245. https://doi.org/https://doi.org/10.32708/uutfd.732671