Yıl: 2020 Cilt: 24 Sayı: 4 Sayfa Aralığı: 321 - 326 Metin Dili: İngilizce DOI: 10.25179/tjem.2020-77613 İndeks Tarihi: 05-05-2021

Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis

Öz:
Objective: A growing body of evidence shows a close relationship between oxidative stress and autoimmune conditions such as Hashimoto’s thyroiditis (HT). Among differentmarkers of oxidative damage, 8-hydroxydeoxyguanosine(8-OHdG) is a ubiquitous marker and broadly used in research studies. Therefore, this study aimed to measure thelevel of 8-OHdG in the sera of patients with HT and healthycontrol (HC) participants. Material and Methods: In thisstudy, patients were diagnosed with clinical (n=23) andsubclinical (n=25) hypothyroidism because of HT and compared with 35 healthy participants. 8-OHdG was measuredusing enzyme-linked immunosorbent assay in patients andHC participants. Results: No significant difference was observed in the mean serum 8-OHdG levels between patientsand HC participants. Conclusion: The results of this preliminary study do not support the fact that the serum level of8-OHdG is a biomarker of oxidative stress in patients withHT. However, more detailed studies are needed to reveal theexact role of 8-OHdG in this autoimmune disease of thethyroid gland.
Anahtar Kelime:

Hashimoto Tiroiditi Olan Hastalarda Serum 8-OHdG Düzeyleri

Öz:
Amaç: Giderek artan sayıda kanıt, oksidatif stres ile Hashimoto tiroiditi (HT) gibi otoimmün durumlar arasında yakın bir ilişki olduğunu göstermektedir. Oksidatif hasarın farklı belirteçleri arasında, 8-hidroksideoksiguanozin (8-OHdG) yaygın bir belirteçtir ve araştırma çalışmalarında geniş ölçüde kullanılmaktadır. Bu nedenle, bu çalışma HT hastalarının ve sağlıklı kontrol (SK) grubunun serumlarında 8-OHdG düzeyini ölçmeyi amaçlamıştır. Gereç ve Yöntemler: Bu çalışmada hastalara HT nedeniyle klinik (n=23) ve subklinik (n=25) hipotiroidizm tanısı konulmuş ve 35 sağlıklı katılımcı ile karşılaştırılmıştır. 8-OHdG, hastalarda ve SK grubunda enzime bağlı immünosorbent testi kullanılarak ölçülmüştür. Bulgular: Hastalar ve SK grubu arasında ortalama serum 8-OHdG düzeylerinde anlamlı bir fark izlenmemiştir. Sonuç: Bu ön çalışmanın sonuçları, HT hastalarında serum 8-OHdG düzeyinin oksidatif stresin bir biyobelirteci olduğu gerçeğini desteklememektedir. Bununla birlikte, tiroid bezinin bu otoimmün hastalığında 8- OHdG'nin tam rolünü ortaya çıkarmak için daha detaylı çalışmalara ihtiyaç vardır.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA esfahanian f, KIAIE S, Ghelich R, Jadali Z (2020). Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. , 321 - 326. 10.25179/tjem.2020-77613
Chicago esfahanian fatemeh,KIAIE Seyedeh Mahdieh,Ghelich Roghayeh,Jadali Zohreh Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. (2020): 321 - 326. 10.25179/tjem.2020-77613
MLA esfahanian fatemeh,KIAIE Seyedeh Mahdieh,Ghelich Roghayeh,Jadali Zohreh Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. , 2020, ss.321 - 326. 10.25179/tjem.2020-77613
AMA esfahanian f,KIAIE S,Ghelich R,Jadali Z Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. . 2020; 321 - 326. 10.25179/tjem.2020-77613
Vancouver esfahanian f,KIAIE S,Ghelich R,Jadali Z Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. . 2020; 321 - 326. 10.25179/tjem.2020-77613
IEEE esfahanian f,KIAIE S,Ghelich R,Jadali Z "Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis." , ss.321 - 326, 2020. 10.25179/tjem.2020-77613
ISNAD esfahanian, fatemeh vd. "Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis". (2020), 321-326. https://doi.org/10.25179/tjem.2020-77613
APA esfahanian f, KIAIE S, Ghelich R, Jadali Z (2020). Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. Turkish Journal of Endocrinology and Metabolism, 24(4), 321 - 326. 10.25179/tjem.2020-77613
Chicago esfahanian fatemeh,KIAIE Seyedeh Mahdieh,Ghelich Roghayeh,Jadali Zohreh Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. Turkish Journal of Endocrinology and Metabolism 24, no.4 (2020): 321 - 326. 10.25179/tjem.2020-77613
MLA esfahanian fatemeh,KIAIE Seyedeh Mahdieh,Ghelich Roghayeh,Jadali Zohreh Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. Turkish Journal of Endocrinology and Metabolism, vol.24, no.4, 2020, ss.321 - 326. 10.25179/tjem.2020-77613
AMA esfahanian f,KIAIE S,Ghelich R,Jadali Z Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. Turkish Journal of Endocrinology and Metabolism. 2020; 24(4): 321 - 326. 10.25179/tjem.2020-77613
Vancouver esfahanian f,KIAIE S,Ghelich R,Jadali Z Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis. Turkish Journal of Endocrinology and Metabolism. 2020; 24(4): 321 - 326. 10.25179/tjem.2020-77613
IEEE esfahanian f,KIAIE S,Ghelich R,Jadali Z "Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis." Turkish Journal of Endocrinology and Metabolism, 24, ss.321 - 326, 2020. 10.25179/tjem.2020-77613
ISNAD esfahanian, fatemeh vd. "Serum Levels of 8-OHdG in Patients with Hashimoto’s Thyroiditis". Turkish Journal of Endocrinology and Metabolism 24/4 (2020), 321-326. https://doi.org/10.25179/tjem.2020-77613