Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou

Akilli, Huseyin; Kucukyildiz, Irem; Ayhan, Ali; Gunakan, Emre; Tunç, Mehmet; Tohma, Yusuf Aytaç; HABERAL REYHAN, ASUMAN NİHAN

doi:10.4274/jtgga.galenos.2020.2020.0153

Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou

Hüseyin AKILLI, (Başkent Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Türkiye)

Emre GÜNAKAN, (Başkent Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

İrem KÜÇÜKYILDIZ, (Sivas Cumhuriyet Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Anabilim Dalı, Sivas, Türkiye)

Mehmet TUNÇ, (Ankara Keçiören Eğitim ve Araştırma Hastanesi, Kadın Hastalıkları ve Doğum Kliniği , Türkiye)

Nihan HABERAL REYHAN, (Başkent Üniversitesi Tıp Fakültesi, Patoloji Anabilim Dalı, Türkiye)

Ali AYHAN, (Başkent Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Ankara, Türkiye)

Yusuf Aytaç TOHMA (Başkent Üniversitesi Tıp Fakültesi, Kadın Hastalıkları ve Doğum Anabilim Dalı, Türkiye)

Journal of the Turkish-German Gynecological Association

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Yıl: 2021 Cilt: 22 Sayı: 1 Sayfa Aralığı: 37 - 41 Metin Dili: İngilizce DOI: 10.4274/jtgga.galenos.2020.2020.0153 İndeks Tarihi: 06-05-2021

Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou

Öz:

Objective: The primary aim of this study was to evaluate the factors affecting parametrial involvement in cervical cancer patients with tumor size ≤4 cm and selection of the low-risk patient group based on long-term oncologic outcomes.Material and Methods: Cervical cancer patients operated in the gynecologic oncology division between 2007 and 2013 were retrospectively evaluated. One-hundred and sixty-eight patients with tumor size ≤4 cm were identified. Of these, 159 (86.8%) underwent radical hysterectomy plus pelvic-para-aortic lymphadenectomy and nine (13.2%) underwent fertility-sparing surgery [radical trachelectomy (n=7); large conization (n=2)]. Factors affecting parametrial invasion, including lymphovascular space invasion (LVSI), deep stromal invasion (DSI), lymph node metastases, and tumor size, were evaluated. Statistical analyses were performed using SPSS 23.0 (IBM Corp., Armonk, NY, USA).Results: Median age was 49.5 years and median tumor size was 2.5 cm (0.45-4 cm). In both univariate and multivariate analyses, the risk of parametrial involvement was increased with LVSI with a hazard ratio (HR) of 3.45 [95% confidence interval (CI): 1.1-10.8] and DSI with a HR of 4.1 (95% CI: 1.18-14.8), while tumor size of ≤2 cm was only significant in univariate analyses. Furthermore, 26 early-stage patients were identified with low-risk factors and they had no parametrial involvement, lymph node metastases, recurrence, or death from disease over 77 months.Conclusion: Parametrial involvement in low-risk cervical cancer is very rare and less radical procedures may be safe in these patients. (J Turk Ger Gynecol Assoc 2021; 22: 37-41)

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Akilli H, Gunakan E, Kucukyildiz I, Tunç M, HABERAL REYHAN A, Ayhan A, Tohma Y (2021). Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. , 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
Chicago	Akilli Huseyin,Gunakan Emre,Kucukyildiz Irem,Tunç Mehmet,HABERAL REYHAN ASUMAN NİHAN,Ayhan Ali,Tohma Yusuf Aytaç Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. (2021): 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
MLA	Akilli Huseyin,Gunakan Emre,Kucukyildiz Irem,Tunç Mehmet,HABERAL REYHAN ASUMAN NİHAN,Ayhan Ali,Tohma Yusuf Aytaç Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. , 2021, ss.37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
AMA	Akilli H,Gunakan E,Kucukyildiz I,Tunç M,HABERAL REYHAN A,Ayhan A,Tohma Y Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. . 2021; 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
Vancouver	Akilli H,Gunakan E,Kucukyildiz I,Tunç M,HABERAL REYHAN A,Ayhan A,Tohma Y Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. . 2021; 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
IEEE	Akilli H,Gunakan E,Kucukyildiz I,Tunç M,HABERAL REYHAN A,Ayhan A,Tohma Y "Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou." , ss.37 - 41, 2021. 10.4274/jtgga.galenos.2020.2020.0153
ISNAD	Akilli, Huseyin vd. "Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou". (2021), 37-41. https://doi.org/10.4274/jtgga.galenos.2020.2020.0153

APA	Akilli H, Gunakan E, Kucukyildiz I, Tunç M, HABERAL REYHAN A, Ayhan A, Tohma Y (2021). Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. Journal of the Turkish-German Gynecological Association, 22(1), 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
Chicago	Akilli Huseyin,Gunakan Emre,Kucukyildiz Irem,Tunç Mehmet,HABERAL REYHAN ASUMAN NİHAN,Ayhan Ali,Tohma Yusuf Aytaç Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. Journal of the Turkish-German Gynecological Association 22, no.1 (2021): 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
MLA	Akilli Huseyin,Gunakan Emre,Kucukyildiz Irem,Tunç Mehmet,HABERAL REYHAN ASUMAN NİHAN,Ayhan Ali,Tohma Yusuf Aytaç Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. Journal of the Turkish-German Gynecological Association, vol.22, no.1, 2021, ss.37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
AMA	Akilli H,Gunakan E,Kucukyildiz I,Tunç M,HABERAL REYHAN A,Ayhan A,Tohma Y Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. Journal of the Turkish-German Gynecological Association. 2021; 22(1): 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
Vancouver	Akilli H,Gunakan E,Kucukyildiz I,Tunç M,HABERAL REYHAN A,Ayhan A,Tohma Y Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou. Journal of the Turkish-German Gynecological Association. 2021; 22(1): 37 - 41. 10.4274/jtgga.galenos.2020.2020.0153
IEEE	Akilli H,Gunakan E,Kucukyildiz I,Tunç M,HABERAL REYHAN A,Ayhan A,Tohma Y "Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou." Journal of the Turkish-German Gynecological Association, 22, ss.37 - 41, 2021. 10.4274/jtgga.galenos.2020.2020.0153
ISNAD	Akilli, Huseyin vd. "Factors affecting parametrial involvement in cervicalcancer patients with tumor size ≤4 cm and selectionof low-risk patient grou". Journal of the Turkish-German Gynecological Association 22/1 (2021), 37-41. https://doi.org/10.4274/jtgga.galenos.2020.2020.0153